LQ23
LQ23 is a selective inhibitor for CDC2-like kinase 2 (CLK2) with an IC50 of 1.4 nM. LQ23 exhibits anti-inflammatory activity.
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- CAS 番号: 2997615-62-8
- 分子式: C24H24N4OS
- 分子量:416.54
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
IC50: 1.4 nM (CLK2), 2.1 nM (CLK1), 3.2 nM (CLK4), 21.7 nM (DYRK1A), >100 nM (CLK3)
LQ23 (10-100 nM) dose-dependently inhibits SR protein phosphorylation in chondrocytes, and thereby regulates the selective cleavage of genes[1].
LQ23 (10-100 nM) dose-dependently inhibits CHIR99021-stimulated Wnt-signaling in HEK-293T cells with IC50 of 2.9 μM[1].
LQ23 (30 nM) ameliorates osteoarthritis through promotes the bone mesenchymal stem cells (BMSC) differentation into chondrocytes and suppresses the cartilage degradation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Chondrocytes
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Concentration:10-100 nM
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Incubation Time:1 h
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Result:Reduced phosphorylated SRSF4, SRSF5 and SRSF6.
Reduced levels of β-catenin and c myc.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MIA-/ACLT-pMMx-induced osteoarthritis in Sprague-Dawley rats model[1]
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Dosage:1.5 μg/ kg
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Administration:Single IA injection
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Result:Ameliorated the surface of the articular cartilage and the cell arrangement, reduced the thickness of the synovium, increased the gap between the femur and the tibia.
Reduced the levels of inflammatory cytokines and catabolic enzymes.
化学情報
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CAS 番号 2997615-62-8
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分子量 416.54
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分子式 C24H24N4OS
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SMILES
N[C@H](COC1=CC(C2=CC=C(C3=C2)NN=C3C#CC4=CSC=C4)=CN=C1)CC(C)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
LQ23 関連分類
HY-162398 関連分類
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