ND-336
Based on 1 Customer Validation
ND-336 is a selective inhibitor of matrix metalloproteinase (MMP)-2, MMP-9, and MMP-14, with Kis of 85, 150, and 120 nM, respectively. ND-336 accelerates diabetic wound healing in mice by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 97.16%
- CAS 番号: 1807453-83-3
- 分子式: C16H18ClNO3S2
- 分子量:371.90
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保管条件:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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MMP-2 85 nM (Ki) |
MMP-9 150 nM (Ki) |
MMP-14 120 nM (Ki) |
ND-336 (0.05-0.01 mg; topical application; daily for 14 day) accelerates diabetic wound healing[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female diabetic db/db mice[1]
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Dosage:0.05, 0.025, and 0.01 mg
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Administration:Topical application; daily for 14 day
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Result:Healed 1.2- to 1.6-fold faster than those treated with ND-322 than those treated with vehicle.
化学情報
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CAS 番号 1807453-83-3
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性状 Solid
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分子量 371.90
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分子式 C16H18ClNO3S2
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Color White to off-white
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SMILES
NCC1=CC=C(OC2=CC=C(C=C2)S(CC3SC3)(=O)=O)C=C1.Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
DMSO : 30 mg/mL (80.67 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Gao M, et al. Acceleration of diabetic wound healing using a novel protease-anti-protease combination therapy. Proc Natl Acad Sci U S A. 2015;112(49):15226-15231. [Content Brief]
[2]. Nguyen TT, et al. Validation of Matrix Metalloproteinase-9 (MMP-9) as a Novel Target for Treatment of Diabetic Foot Ulcers in Humans and Discovery of a Potent and Selective Small-Molecule MMP-9 Inhibitor That Accelerates Healing. J Med Chem. 2018;61(19):8825-8837. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6889 mL | 13.4445 mL | 26.8889 mL | 67.2224 mL |
| 5 mM | 0.5378 mL | 2.6889 mL | 5.3778 mL | 13.4445 mL | |
| 10 mM | 0.2689 mL | 1.3444 mL | 2.6889 mL | 6.7222 mL | |
| 15 mM | 0.1793 mL | 0.8963 mL | 1.7926 mL | 4.4815 mL | |
| 20 mM | 0.1344 mL | 0.6722 mL | 1.3444 mL | 3.3611 mL | |
| 25 mM | 0.1076 mL | 0.5378 mL | 1.0756 mL | 2.6889 mL | |
| 30 mM | 0.0896 mL | 0.4481 mL | 0.8963 mL | 2.2407 mL | |
| 40 mM | 0.0672 mL | 0.3361 mL | 0.6722 mL | 1.6806 mL | |
| 50 mM | 0.0538 mL | 0.2689 mL | 0.5378 mL | 1.3444 mL | |
| 60 mM | 0.0448 mL | 0.2241 mL | 0.4481 mL | 1.1204 mL | |
| 80 mM | 0.0336 mL | 0.1681 mL | 0.3361 mL | 0.8403 mL |
ND-336 関連分類
HY-124373 関連分類
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