PHA 408
Based on 1 publication(s) in Google Scholar
PHA 408 (PHA-408) is a potent, selective and orally active IκB kinase-2 (IKK-2) inhibitor. PHA 408 is a powerful anti-inflammatory agent against lipopolysaccharide (LPS)- and cigarette smoke (CS)-mediated lung inflammation.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.40%
- CAS 番号: 503555-55-3
- 分子式: C29H27ClFN7O2
- 分子量:560.02
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 PHA 408
More
生物活性
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IKK-2 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| PBMC | IC50 |
39 nM
Compound: PHA-408
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Inhibition of LPS-stimulated TNFalpha release in human PBMC
Inhibition of LPS-stimulated TNFalpha release in human PBMC
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[PMID: 21236687] |
化学情報
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CAS 番号 503555-55-3
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性状 Solid
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分子量 560.02
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分子式 C29H27ClFN7O2
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Color Off-white to light yellow
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SMILES
O=C(C1=NN(C2=CC=C(F)C=C2)C3=C1CCC4=CC=C(NC(C5=C(Cl)C=NC(N6CCN(C)CC6)=C5)=O)C=C43)N
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Sci Transl Med
PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells. [Abstract]2018 Jul 18;10(450):eaaq1093. PMID: 30021885
溶剤 & 溶解度
DMSO : 50 mg/mL (89.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7857 mL | 8.9283 mL | 17.8565 mL | 44.6413 mL |
| 5 mM | 0.3571 mL | 1.7857 mL | 3.5713 mL | 8.9283 mL | |
| 10 mM | 0.1786 mL | 0.8928 mL | 1.7857 mL | 4.4641 mL | |
| 15 mM | 0.1190 mL | 0.5952 mL | 1.1904 mL | 2.9761 mL | |
| 20 mM | 0.0893 mL | 0.4464 mL | 0.8928 mL | 2.2321 mL | |
| 25 mM | 0.0714 mL | 0.3571 mL | 0.7143 mL | 1.7857 mL | |
| 30 mM | 0.0595 mL | 0.2976 mL | 0.5952 mL | 1.4880 mL | |
| 40 mM | 0.0446 mL | 0.2232 mL | 0.4464 mL | 1.1160 mL | |
| 50 mM | 0.0357 mL | 0.1786 mL | 0.3571 mL | 0.8928 mL | |
| 60 mM | 0.0298 mL | 0.1488 mL | 0.2976 mL | 0.7440 mL | |
| 80 mM | 0.0223 mL | 0.1116 mL | 0.2232 mL | 0.5580 mL |
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