QTX125
Based on 1 publication(s) in Google Scholar
QTX125 is a potent and highly selective HDAC6 inhibitor. QTX125 exhibits excellent selectivity over other HDACs. QTX125 has antitumor effects.
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- CAS 番号: 1279698-31-5
- 分子式: C23H19N3O5
- 分子量:417.41
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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MedChemExpress（MCE）の使用を引用している文献 QTX125
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生物活性
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HDAC6 |
QTX125 (25-500 nM; 24-48 hours) treatment induces the subsequent apoptosis demonstrated by annexin V/propidium iodide double staining and the cleavage of caspase-9, caspase-8, caspase-3, and PARP[1].
In MCL cell lines MINO, REC-1, IRM-2 and HBL-2 cells, QTX125 (10 nM, 10 μM, 100 μM) induces dose-dependent hyperacetylation of α-tubulin[1].
QTX125 has the strongest growth-inhibitory effect in Burkitt cell lymphoma, follicular lymphoma, and mantle cell lymphoma (MCL)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MINO, REC-1, IRM-2 and HBL-2 cells
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Concentration:25 nM, 50 nM, 100 nM, 500 nM
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Incubation Time:24 hours, 48 hours
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Result:Inhibited annexin V/propidium iodide double staining.
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Cell Line:MINO, REC-1, IRM-2 and HBL-2 cells
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Concentration:25 nM, 50 nM, 100 nM, 500 nM
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Incubation Time:24 hours
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Result:Inhibited the cleavage of caspase-9, caspase-8, caspase-3, and PARP.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Nude mice bearing REC-1 or MINO cells[1]
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Dosage:60 mg/kg
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Administration:Intraperitoneal administration; daily dosing for 5 days; for 4 weeks
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Result:Inhibited tumor growth in REC-1 or MINO cells xenografted in nude mice.
化学情報
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CAS 番号 1279698-31-5
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分子量 417.41
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分子式 C23H19N3O5
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SMILES
O=C(C1=C(C2=COC=C2)C=C(C3=CC=C(O)C=C3)N1)NCC4=CC=C(C(NO)=O)C=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Nanobiotechnology
Multifunctional CaCO3@Cur@QTX125@HA nanoparticles for effectively inhibiting growth of colorectal cancer cells. [Abstract]2023 Sep 29;21(1):353. PMID: 37773145
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
QTX125 関連分類
HY-120448 関連分類
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