Vescalagin
Vescalagin is a hexahydroxyphenol. Vescalagin is isolable from Camu-camu (Myrciaria dubia) and immature wax apple fruits. Vescalagin exhibits inhibitory activity against a variety of enzymes, with a Ki value of 5.87 nM against AChE, 3.89 nM against BChE, 11.75 nM against hCA I, 16.23 nM against hCA II, and 16.08 nM against α-glucosidase. Vescalagin inhibits hCA I, hCA II and α-glucosidase in a non-competitive manner. Vescalagin downregulates JNK/p38 MAPK to protect pancreatic β-cells and improve insulin secretion in methylglyoxal-treated rats. Vescalagin reduces hyperglycemia and hypertriglyceridemia in rats fed a high-fructose diet. Vescalagin possesses anti-inflammatory and antioxidant properties.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 36001-47-5
- 分子式: C41H26O26
- 分子量:934.63
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
AChE 5.87 nM (Ki) |
BChE 3.89 nM (Ki) |
hCA I 11.75 nM (Ki) |
hCA II 16.23 nM (Ki) |
α‑glucosidase 16.08 nM (Ki) |
体外実験
Vescalagin is an inhibitor of acetylcholinesterase (AChE) with a Ki value of 5.87 nM[1].
Vescalagin is an inhibitor of butyrylcholinesterase (BChE) with a Ki value of 3.89 nM[1].
Vescalagin acts as a non-competitive inhibitor of α-glucosidase with a Ki value of 16.08 nM[1].
Vescalagin acts as a non-competitive inhibitor of hCA I with a Ki value of 11.75 nM[1].
Vescalagin acts as a non-competitive inhibitor of hCA II with a Ki value of 16.23 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
Vescalagin reduces hyperglycemia and hypertriglyceridemia in rats fed a high-fructose diet[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 36001-47-5
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分子量 934.63
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分子式 C41H26O26
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SMILES
OC1=C(O)C(O)=C(C2=C3C=C(O)C(O)=C2O)C=C1C(OC[C@](OC(C4=C(C5=C6C(C7=C(C(O[C@@]8([H])[C@@H]9O)=O)C9=C(O)C(O)=C7O)=C(O)C(O)=C5O)C(O)=C(O)C(O)=C4)=O)([H])[C@@]([C@@H]8OC6=O)([H])OC3=O)=O
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Vescalagin 関連分類
HY-N19401 関連分類
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