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C646

97 Cited Publications
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Based on 97 publication(s) in Google Scholar

C646 is a selective and competitive histone acetyltransferase p300 inhibitor with Ki of 400 nM, and is less potent for other acetyltransferases.

For research use only. We do not sell to patients.

  • Purity: 99.88%
  • CAS No.: 328968-36-1
  • Formula: C24H19N3O6
  • Molecular Weight:445.42
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • C646 Chemical Structure
    C646 Chemical Structure
  • Experimental Validation Results for C646
  • Experimental Validation Results for C646
  • Experimental Validation Results for C646
  • Experimental Validation Results for C646
  • Experimental Validation Results for C646
CAS No.: 328968-36-1
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All Histone Acetyltransferase Isoforms

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All Epigenetic Reader Domain Isoforms

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  • C646 Chemical Structure
    C646 Chemical Structure
    1/16
  • 1/16

    C646 purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2023 Apr:210:115497. [Abstract]

    Customer Validation
     C646 (20 μM) decreases the expression of PLK1 following effective inhibition of H3K27ac, and αSMA and COLI are also repressed, in TGFβ-activated LX2 cells.

  • 1/16

    C646 purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2018 Nov;25(11):1980-1995. [Abstract]

    Customer Validation
     Western blot analysis of LAMC2 expression after C646 treatment in KYSE150 and KYSE450. C646 treatment: 20μM, 12h.

  • 1/16

    C646 purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2018 Aug 20:124:454-465. [Abstract]

    Customer Validation
     To explore whether P300 is required for NaB’s activation of Nrf2 expression and function, HG-treated endothelial cells (ECs) are co-treated with NaB, in the presence or absence of C646.

  • 1/16

    C646 purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2017 Oct 5:812:206-215. [Abstract]

    Customer Validation
     C646 inhibits the proliferation of Cervical cancer cells and induced the accumulation of p53 protein. Protein levels of p53 and p21 are augmented by C646 in a dose-dependent manner. Whole cell lysates are analyzed with western-blot analysis.

  • 1/16

    C646 purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2016 Dec 2;481(1-2):90-96. [Abstract]

    Customer Validation
     DMKG inhibits autophagy of HSCs via acetyl-coenzyme A and EP300. Western blot analysis of LC3B, Beclin-1, a-SMA, and collagen-I expression from lysates of HSC-T6 incubated with control media, DMKG (4 mM), or Lipoic acid (5 mM) in the presence or absence of C646 (10 mM) for 12 h.

  • C646