9MW3811
9MW3811 is an anti-IL-11 antibody with an EC50 of 0.1-0.3 nM against hIL-11, mouse, rat, and Canis IL-11. 9MW3811 blocks the JAK/STAT3 signaling pathway. 9MW3811 has a synergistic effect with anti-PD-1 antibodies, even in PD-1 non-responsive models. 9MW3811 shows antitumor effects in NSCLC, LUAD, lung cancer, and liver cancer models. 9MW3811 can be used for research on solid tumors and hepatocellular carcinoma.
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
Species Reactivity
Human
IC50 & Target
[1]|
IL-11 |
STAT3 |
In Vitro
9MW3811 (30 min) blocked IL-11/IL-11Rα/gp130 complex formation in a blocking ELISA with an EC50 of 6.7 nM[1].
9MW3811 (6 h) dose-dependently inhibited STAT3-driven luciferase expression in IL-11Rα/STAT3-luc HEK293 cells[1].
9MW3811 blocks the formation of the IL-11/IL-11R/gp130 protein complex in ELISA[2].
9MW3811 inhibits IL-11-mediated signaling in a luciferase reporter cell assay[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HGC-27 cells
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Concentration:Indicated concentrations (9MW3811)
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Incubation Time:16 h (serum-free starvation); 20 min (37 °C, IL-11 + 9MW3811)
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Result:Incubation with 9MW3811 dose-dependently reduced STAT3 phosphorylation.
Inhibition of IL-11-induced phosphorylated ERK was also observed.
Parmacokinetics
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c nude (female, 6-8 weeks old)[1]
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Dosage:0.4 mg/kg; 2.0 mg/kg
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Administration:i.p.; BIW×9
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Result:Inhibited tumor growth at 2 mg/kg versus isotype control hIgG, with tumor growth inhibition (TGI) of 62%.
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Animal Model:NOD/SCID (female, 6-8 weeks old)[1]
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Dosage:10.0 mg/kg
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Administration:i.p.; BIW×8
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Result:Resulted in TGI of 50% in the LU5351 PDX model at 10 mg/kg.
Gene ID
Accession
Target
IL-11
Conjugated
Unconjugated
신청
ELISA, FACS, Functional assay
Chemical Information
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SMILES
[9MW3811]
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
9MW3811 Related Classifications
HY-P992531 Related Classifications
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