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Cat. No.: HY-114583

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AMG-8562

AMG-8562 is a TRPV1 modulator. AMG-8562 blocks Capsaicin (HY-10448) activation of TRPV1 without affecting heat activation of TRPV1. AMG-8562 potentiates pH 5 activation of TRPV1. AMG-8562 blocks capsaicin-induced flinching behavior in pain models. AMG-8562 produces significant efficacy in CFA- and skin incision-induced thermal hyperalgesia, and in the Acetic acid (HY-Y0319)-induced writhing models.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 1041478-78-7
화학식: C₂₄H₂₅F₃N₂O₂
분자량:430.47

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

AMG-8562 Chemical Structure

CAS No.: 1041478-78-7

사이즈

가격

재고

수량

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

TRPV1

All TRP Channel Isoforms :

Chemical Information

CAS No. 1041478-78-7
분자량 430.47
화학식 C₂₄H₂₅F₃N₂O₂
SMILES

C(=C/C(NC1=C2C(C[C@@H](O)C2)=CC=C1)=O)\C3=C(C=C(C(F)(F)F)C=C3)N4CCCCC4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Vay L, et al. Current perspectives on the modulation of thermo-TRP channels: new advances and therapeutic implications. Expert Rev Clin Pharmacol. 2010 Sep;3(5):687-704. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
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Purity:
수량:

AMG-8562

All TRP Channel Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

AMG-8562 Related Classifications

HY-114583 Related Classifications