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Cat. No.: HY-184487

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Anticancer agent 331

Anticancer agent 331 is an anticancer agent with favorable cell permeability and limited blood-brain barrier penetration. Anticancer agent 331 forms stable long-acting complexes with TNF-α, PI3K p110α, AKT1 and mTOR, and exerts cytotoxic effects on cancer cells. Anticancer agent 331 can be used in the research of colorectal cancer.

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화학식: C₂₉H₂₀ClN₅O₃S₂
분자량:586.08

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anticancer agent 331 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

Akt1

p110α

All TNF Receptor Isoforms :

All PI3K Isoforms :

All Akt Isoforms :

All mTOR Isoforms :

In Vitro

Anticancer agent 331 (compound 5d) (4.10-49.08 µM) potently inhibits human colorectal carcinoma HCT-116 cell viability with an IC₅₀ of 4.10 µM and exhibits high selectivity for cancer cells over human dermal fibroblast CCD-1076Sk cells, with a selectivity index of 12.0^[1].
Anticancer agent 331 has a viable pharmacokinetic profile, with acceptable intestinal permeability, good predicted oral absorption, limited blood-brain barrier penetration, and two Lipinski rule of five violations typical of potent kinase inhibitors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 586.08
화학식 C₂₉H₂₀ClN₅O₃S₂
SMILES

O=S(C1=CN=CC=C1)(N2C=C(C3=CC=CC=C32)/C=N/N=C4SC=C(N\4C5=CC=CC(Cl)=C5)C6=CC=C(C=C6)O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Batool Z, et al. Synthesis, biological evaluation and detailed computational studies of N-sulfonyl indole-based dihydrothiazoles against colorectal carcinoma. Scientific reports. 2026 Jun 10;16(1):18334. [Content Brief]

Calculators

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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Anticancer agent 331

All TNF Receptor Isoforms

All PI3K Isoforms

All Akt Isoforms

All mTOR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Anticancer agent 331 Related Classifications

HY-184487 Related Classifications