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Cat. No.: HY-147717

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CDK8-IN-7

CDK8-IN-7 (compound 12) is a potent and selective cyclin-dependent kinase 8 (CDK8) inhibitor with an K_d of 3.5 nM. CDK8-IN-7 shows cytotoxicity for MOLM-13, OCI-AML3, MV4-11, NRK and H9c2 cells with IC₅₀s of 5.9, 4.8, 5.4, 16.2, 12.5-25 µM, respectively. CDK8-IN-7 has the potential for the research of AML-cancer.

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CAS No.: 2415156-30-6
화학식: C₃₀H₄₀N₂
분자량:428.65

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

CDK8-IN-7 Chemical Structure

CAS No.: 2415156-30-6

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수량

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

CDK8

3.5 nM (Kd)

All CDK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
H9c2	EC₅₀	12.5 μM Compound: 12	Cytotoxicity against rat H9c2 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay Cytotoxicity against rat H9c2 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay	[PMID: 32245563]
MOLM-13	EC₅₀	5.9 μM Compound: 12	Cytotoxicity against human MOLM13 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay Cytotoxicity against human MOLM13 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay	[PMID: 32245563]
MV4-11	EC₅₀	5.4 μM Compound: 12	Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay	[PMID: 32245563]
NRK	EC₅₀	16.2 μM Compound: 12	Cytotoxicity against rat NRK cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay Cytotoxicity against rat NRK cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay	[PMID: 32245563]
OCI-AML-3	EC₅₀	4.8 μM Compound: 12	Cytotoxicity against human OCI-AML3 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay Cytotoxicity against human OCI-AML3 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay	[PMID: 32245563]

Chemical Information

CAS No. 2415156-30-6
분자량 428.65
화학식 C₃₀H₄₀N₂
SMILES

C[C@@]12C(C3=CC=CC4=C3C=CN=C4)=CC[C@@]1([H])[C@]5([H])CC[C@@]6([H])C[C@H](N(C)C)CC[C@]6(C)[C@@]5([H])CC2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Solum E, et al. New CDK8 inhibitors as potential anti-leukemic agents - Design, synthesis and biological evaluation. Bioorg Med Chem. 2020 May 15;28(10):115461. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
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수량:
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CDK8-IN-7

All CDK Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

CDK8-IN-7 Related Classifications

HY-147717 Related Classifications