Cimiside E
Cimiside E (25-Anhydrocimigenol xyloside) is a triterpene xyloside, Cimiside E possesses apoptotic action on gastric cancer cells, with an IC50 value of 14.58 μM. Cimiside E induces cell cycle arrest at G2/M phase, and mediates apoptosis through the induction of the caspase cascade for both the extrinsic and intrinsic pathways.
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- CAS No.: 154822-57-8
- 화학식: C35H54O8
- 분자량:602.80
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
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Biological Activity
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Caspase 3 |
Cimiside E (30-90 μM; 24 h) arrest cell cycle and induces apoptosis in ASG cells[1].
Cimiside E (30-90 μM; 12-48 h) has a strong cytotoxicity on AGS cells and shows anti-proliferative activity[1].
Cimiside E (15-60 μM; 6-24 h) induces DNA fragment, (30-60; 1-6 h) activates expression of FasL at 3 h and Fas from 1 h in ASG cells[1].
Cimiside E (30-90 μM; 3-24 h) mediates caspase cascade, by increasing Bax/Bcl-2 ratio and decreasing mutant type (mt) p53 and procaspase 3[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Cimiside E. AGS cells
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Concentration:30 μM, 60 μM, and 90 μM
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Incubation Time:3 h, 6 h, 12 h, and 24 h
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Result:Increased the ratio of Bax/Bcl-2 expression from 60 μM.
Decreased mutant type (mt) p53 levle from 12 h at 30 µM.
Suppressed the protein level of procaspase 3 in a dose-dependent manner from 30 μM.
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Cell Line:Cimiside E. AGS cells
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Concentration:30 μM, 60 μM, and 90 μM
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Incubation Time:12 h, 24 h, and 48 h
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Result:Inhibited ASG cells proliferation with IC50s of 28.7, 14.6 and 8.1 µM, respectively, for 30 μM, 60 μM, and 90 μM treatment.
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Cell Line:Cimiside E. AGS cells
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Concentration:30 μM, 60 μM, and 90 μM
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Incubation Time:3 h, 6 h, and 24 h
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Result:Induced cell cycle arrest at S phase in a low concentration (30 μM), but arrested cell cycle at G2/M phase in higher concentration (60 μM and 90 μM).
Chemical Information
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CAS No. 154822-57-8
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분자량 602.80
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화학식 C35H54O8
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SMILES
C[C@]12[C@@]3([H])[C@@]4(CC[C@@]1([C@]5([H])[C@@]6(O[C@]([C@@H](O6)C(C)=C)([H])C[C@H]5C)[C@@H]2O)C)[C@@]7([C@@](C(C)([C@H](CC7)O[C@H]8[C@@H]([C@H]([C@@H](CO8)O)O)O)C)([H])CC3)C4
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Synonyms
25-Anhydrocimigenol xyloside
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Guo LY, et al. Cimiside E arrests cell cycle and induces cell apoptosis in gastric cancer cells. Arch Pharm Res. 2009 Oct;32(10):1385-92. [Content Brief]
[2]. Jamróz MK, et al. One new and six known triterpene xylosides from Cimicifuga racemosa: FT-IR, Raman and NMR studies and DFT calculations. Spectrochim Acta A Mol Biomol Spectrosc. 2012 Jul;93:10-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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