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Cat. No.: HY-100210

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FN-439

FN-439 is a selective collagenase-1 inhibitor. FN-439 inhibits collagenase-1 with an IC₅₀ value of 1 μM. FN-439 can be used for the research of cancer and inflammation.

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CAS No.: 124168-73-6
화학식: C₂₃H₃₄N₆O₆
분자량:490.55

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

FN-439 Chemical Structure

CAS No.: 124168-73-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

FN-439 is a selective collagenase-1 inhibitor. FN-439 inhibits collagenase-1 with an IC₅₀ value of 1 μM. FN-439 can be used for the research of cancer and inflammation^[1]^[2].

All MMP Isoforms :

In Vitro

FN-439 inhibits collagenase-1 with an IC₅₀ value of 1 μM^[1].
FN-439 (1 μM) reduces the invasive potential of MDA-MB-231 breast cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

FN-439 significantly decreases neutrophils and macrophages, shows extensive bone formation and active cementogenesis in the periapical region when has a combination with ofloxaci^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 124168-73-6
분자량 490.55
화학식 C₂₃H₃₄N₆O₆
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. U Benbow, et al. Human breast cancer cells activate procollagenase-1 and invade type I collagen: invasion is inhibited by all-trans retinoic acid. Clin Exp Metastasis. 1999 May;17(3):231-8. [Content Brief]

[2]. H Anan, et al. Effects of a combination of an antibacterial agent (ofloxacin) and a collagenase inhibitor (FN-439) on the healing of rat periapical lesions. J Endod. 1996 Dec;22(12):668-73. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

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FN-439

All MMP Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

FN-439 Related Classifications

HY-100210 Related Classifications