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Cat. No.: HY-144117

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GFB-12811

Name: GFB-12811
Brand: MedChemExpress
SKU: HY-144117
Price: 980.00 USD
Availability: InStock
Rating: 5 (1 reviews)

1 Cited Publications

고객리뷰

Based on 1 publication(s) in Google Scholar

GFB-12811 is a high selective CDK5 inhibitor with an IC₅₀ of 2.3 nM.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity : 98.04%
CAS No.: 2775311-17-4
화학식: C₂₂H₂₃F₄N₅O
분자량:449.44

보관:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

GFB-12811 Chemical Structure

CAS No.: 2775311-17-4

사이즈

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수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
용액&용해도
- In Vitro
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

GFB-12811 is a high selective CDK5 inhibitor with an IC₅₀ of 2.3 nM^[1].

IC₅₀ & Target

^[1]

Cdk5/p25

2.3 nM (IC₅₀)

CDK2/CycA

211 nM (IC₅₀)

CDK7/Cyclin H/MAT1

718 nM (IC₅₀)

CDK9/CycT1

894 nM (IC₅₀)

CDK6

3197 nM (IC₅₀)

All CDK Isoforms :

In Vitro

GFB-12811 exhibits a good metabolic stability and a low clearance in mouse hepatocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

GFB-12811 exhibits oral bioavailability of 25% (3 mg/kg) and 41% (10 mg/kg), which possibly due to the effect of efflux via the Pgp pathway. GFB-12811 has a long half-life of 7.6 h, and a good volume of distribution with V_ss=7.3 L/kg (1 mg/kg, iv) in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2775311-17-4
Appearance Solid
분자량 449.44
화학식 C₂₂H₂₃F₄N₅O
Color Light yellow to yellow
SMILES

CN1CCC(CC1)[C@@](O)(C2=CC=C3C=NC(NC4=CC(C(F)(F)F)=NC=C4F)=CC3=N2)C
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Res Sq

Cyclin-Dependent Kinase 5 Contributes to Bruton's Tyrosine Kinase Inhibitor Resistance via the IRE1α/XBP1 Axis in Mantle Cell Lymphoma. [Abstract]

2026 May 8:rs.3.rs-9500406. PMID: 42147166

용액&용해도

In Vitro:

DMSO : 50 mg/mL (111.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2250 mL

11.1250 mL

22.2499 mL

5 mM

0.4450 mL

2.2250 mL

4.4500 mL

10 mM

0.2225 mL

1.1125 mL

2.2250 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Daniels MH, et al. Discovery and Optimization of Highly Selective Inhibitors of CDK5. J Med Chem. 2022;65(4):3575-3596. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2250 mL	11.1250 mL	22.2499 mL	55.6248 mL
	5 mM	0.4450 mL	2.2250 mL	4.4500 mL	11.1250 mL
	10 mM	0.2225 mL	1.1125 mL	2.2250 mL	5.5625 mL
	15 mM	0.1483 mL	0.7417 mL	1.4833 mL	3.7083 mL
	20 mM	0.1112 mL	0.5562 mL	1.1125 mL	2.7812 mL
	25 mM	0.0890 mL	0.4450 mL	0.8900 mL	2.2250 mL
	30 mM	0.0742 mL	0.3708 mL	0.7417 mL	1.8542 mL
	40 mM	0.0556 mL	0.2781 mL	0.5562 mL	1.3906 mL
	50 mM	0.0445 mL	0.2225 mL	0.4450 mL	1.1125 mL
	60 mM	0.0371 mL	0.1854 mL	0.3708 mL	0.9271 mL
	80 mM	0.0278 mL	0.1391 mL	0.2781 mL	0.6953 mL
	100 mM	0.0222 mL	0.1112 mL	0.2225 mL	0.5562 mL

Bioz

Keywords

GFB-12811

1 Cited Publications

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
용액&용해도
- In Vitro
순도&문서
References

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GFB-12811

Publications Citing Use of MedChemExpress (MCE) GFB-12811

All CDK Isoforms