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Cat. No.: HY-N22071

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Kutkoside

Kutkoside is an orally active iridoid glycoside mixture composed of picroside II, picroside IV, and 6-ferulloylcatalpol. Kutkoside exerts antioxidant effects by targeting hepatic and lysosomal enzymes, inhibiting Xanthine Oxidase (IC₅₀ = 354.6 μM) and lipid peroxidation, and downregulates MMP-1/2/9/13 to suppress tumor invasion and inflammatory mediators. Kutkoside can be used in research on D-galactosamine-induced liver injury and breast cancer.

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CAS No.: 35988-27-3
화학식: C₂₃H₂₈O₁₃
분자량:512.46

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (299 KB)

Kutkoside Chemical Structure

CAS No.: 35988-27-3

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[2]^[4]

Xanthine oxidase

354.6 μM (IC₅₀)

MMP-1

MMP-2

MMP-9

MMP13

All MMP Isoforms :

In Vitro

Anti-cancerOthers

Anti-cancer

Kutkoside (5-10 µM; 48 h) reduces MCF-7 viability to 42.60% at 5 µM and to 28.23% at 10 µM in the MTT assay^[4].
Kutkoside (5 µM; 48 h) induces PI uptake in MCF-7 cells, indicating loss of membrane integrity^[4].
Kutkoside (5-10 µM; 48 hours) inhibits MCF-7 migration and invasion in the wound scratch assay^[4].
Kutkoside (5 µM; 48 h) downregulates gelatinase and collagenase MMP activity in MCF-7 conditioned medium^[4].
Kutkoside (5 µM; 18 h) downregulates MMP-2, MMP-9, MMP-1, and MMP-13 mRNA expression in MCF-7 cells^[4].

Others

Kutkoside inhibits Xanthine oxidase, Microorganism (HY-P2755) activity in the xanthine-xanthine oxidase assay, with an IC₅₀ of 354.6 μM^[2].
Kutkoside inhibits superoxide anion reduction of Nitro blue tetrazolium chloride (NBT) (HY-15925) in the xanthine-xanthine oxidase system, with an IC₅₀ of 291.5 μM^[2].
Kutkoside (90 s) inhibits non-enzymatic superoxide anion generation produced by Phenazine methylsulfate (HY-W004520)/NADH (HY-113355), with an IC₅₀ of 372.3 μM^[2].
Kutkoside (37°C; 90 min) inhibits MDA production from enzymatic lipid peroxidation in rat liver microsomes with an IC₅₀ of 366.9 μM^[2].
Kutkoside (37°C; 90 min) inhibits MDA formation caused by non-enzymatic ascorbic acid/Fe²⁺-stimulated lipid peroxidation in boiled rat liver microsomes, with an IC₅₀ of 561.5 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[4]

Cell Line:

MCF-7 human breast cancer cells
Concentration:

5, 10 µM
Incubation Time:

48 h
Result:

Reduced MCF-7 viability to 42.60% at 5 µM and to 28.23% at 10 µM in the MTT assay.

Cell Cytotoxicity Assay^[4]

Cell Line:

MCF-7 human breast cancer cells
Concentration:

5, 10 µM
Incubation Time:

48 h
Result:

Induced PI uptake in MCF-7 cells, indicating loss of membrane integrity.

Cell Migration Assay ^[4]

Cell Line:

MCF-7 human breast cancer cells
Concentration:

5, 10 µM
Incubation Time:

48 h (Kutkoside); 24 h (post-scratch incubation)
Result:

Significantly blocked MCF-7 tumor invasion and suppressed migration across the wounded space in a dose-dependent manner.

RT-PCR^[4]

Cell Line:

MCF-7 human breast cancer cells
Concentration:

5 µM
Incubation Time:

18 h
Result:

Suppressed relative mRNA expression of gelatinases MMP-2 and MMP-9 and collagenases MMP-1 and MMP-13 in MCF-7 cells.

In Vivo

Kutkoside (12 mg/kg/day; p.o.; daily; 7 days) exerts protective effects against galactosamine-induced hepatic and serum biochemical alterations in Sprague Dawley rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague Dawley (adult male albino, 120 g)^[1]
Dosage:

12 mg/kg/day
Administration:

p.o. (gavage); daily; 7 days
Result:

Exerted protective effects against galactosamine-induced hepatic and serum biochemical alterations in Sprague Dawley rats.

Related Protocols :

Chemical Information

CAS No. 35988-27-3
분자량 512.46
화학식 C₂₃H₂₈O₁₃
SMILES

O=C(C1=CC(OC)=C(C=C1)O)OC[C@@]23[C@]4([H])[C@](C=CO[C@H]4O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)CO)([H])[C@@H]([C@]2([H])O3)O
Structure Classification
- Terpenoids
- Iridoids
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (299 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dwivedi Y, et al. Picroliv and its components kutkoside and picroside I protect liver against galactosamine-induced damage in rats. Pharmacology & toxicology. 1992 Nov;71(5):383-7.

[2]. Chander R, et al. Picroliv, picroside-I and kutkoside from Picrorhiza kurrooa are scavengers of superoxide anions. Biochemical pharmacology. 1992 Jul 07;44(1):180-3.

[3]. Bhandari P, et al. Online HPLC-DPPH method for antioxidant activity of Picrorhiza kurroa Royle ex Benth. and characterization of kutkoside by ultra-performance LC-electrospray ionization quadrupole time-of-flight mass spectrometry. Indian journal of experimental biology. 2010 Mar;48(3):323-8.

[4]. Rathee D, et al. Iridoid glycosides-Kutkin, Picroside I, and Kutkoside from Picrorrhiza kurroa Benth inhibits the invasion and migration of MCF-7 breast cancer cells through the down regulation of matrix metalloproteinases: 1st Cancer Update[J]. Arabian Journal of Chemistry, 2013, 6(1): 49-58.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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