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Cat. No.: HY-P10072

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MK2-IN-5

Name: MK2-IN-5
Brand: MedChemExpress
SKU: HY-P10072
Availability: PreOrder

(Synonyms: Hsp25 kinase inhibitor; Mk2 pseudosubstrate)

1 Cited Publications

고객리뷰

Based on 1 publication(s) in Google Scholar

MK2-IN-5 is a Mk2 pseudosubstrate (K_i= 8 μM). MK2-IN-5 targets the protein interaction domain in the MAPK pathway. MK2-IN-5 inhibits HSP25 and HSP27 phosphorylation.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 474713-20-7
화학식: C₆₁H₁₁₃N₂₁O₁₆
분자량:1396.68

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

MK2-IN-5 Chemical Structure

CAS No.: 474713-20-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
순도&문서
References
Calculators
Help & FAQs
Classifications
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Biological Activity

제품 설명

MK2-IN-5 is a Mk2 pseudosubstrate (K_i= 8 μM). MK2-IN-5 targets the protein interaction domain in the MAPK pathway. MK2-IN-5 inhibits HSP25 and HSP27 phosphorylation^[1]^[2]^[3].

IC₅₀ & Target

ERK1

ERK2

All ERK Isoforms :

All JNK Isoforms :

All p38 MAPK Isoforms :

All HSP Isoforms :

In Vitro

MK2-IN-5 (5-10 μM, 2 h) inhibits TGF-b1 induced connective tissue growth factor (CTGF) and collagen type I in primary human keloid fibroblasts^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MK2-IN-5 (2 mg/kg Intraperitoneal injection, single dose) decreased HSP25 phosphorylation in ventilator-associated lung injury model^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ventilator-associated lung injury model^[2]
Dosage:

2 mg/kg
Administration:

Intraperitoneal injection (i.p.)
Result:

Decreased HSP25 phosphorylation.

Chemical Information

CAS No. 474713-20-7
분자량 1396.68
화학식 C₆₁H₁₁₃N₂₁O₁₆
Synonyms

Hsp25 kinase inhibitor; Mk2 pseudosubstrate
Sequence

Lys-Lys-Lys-Ala-Leu-Asn-Arg-Gln-Leu-Gly-Val-Ala-Ala
Sequence Shortening

KKKALNRQLGVAA
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

Adv Sci (Weinh)

Enhancing CAR-T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF-Mediated Angiogenesis. [Abstract]

2026 May 6:e21975. PMID: 42089445

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gaestel M, et al. Peptides as signaling inhibitors for mammalian MAP kinase cascades [J]. Current pharmaceutical design, 2009, 15(21): 2471-2480. [Content Brief]

[2]. Damarla M, et al. Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury [J]. PloS one, 2009, 4(2): e4600. [Content Brief]

[3]. Lopes L B, et al. Inhibition of HSP27 phosphorylation by a cell-permeant MAPKAP Kinase 2 inhibitor [J]. Biochemical and biophysical research communications, 2009, 382(3): 535-539. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
순도&문서
References

상품명:
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MK2-IN-5

Astragaloside IV

Astragaloside IV (Standard)

Publications Citing Use of MedChemExpress (MCE) MK2-IN-5

All ERK Isoforms

All JNK Isoforms

All p38 MAPK Isoforms

All HSP Isoforms

Biological Activity

Chemical Information

Publications (1)

순도&문서

References

Calculators

Help & FAQs

Bioz

MK2-IN-5

Astragaloside IV

Astragaloside IV (Standard)

Publications Citing Use of MedChemExpress (MCE) MK2-IN-5

All ERK Isoforms

All JNK Isoforms

All p38 MAPK Isoforms

All HSP Isoforms

Biological Activity

Chemical Information

Publications (1)

순도&문서

References

Calculators

Help & FAQs

MK2-IN-5 Related Classifications

HY-P10072 Related Classifications

Bioz