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Cat. No.: HY-180957

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NEP108

NEP108 is a GID4 E3 ligase-based BRD4 PROTAC degrader, with its DC₅₀ value approximately 3.8 μM. NEP108 has a strong affinity for GID4, with a K_D value of 0.22 μM, and the K_D value of its trimeric complex is 2.85 μM. NEP108 can be used for cancer research.
(Pink: BRD4 ligand (HY-78695); Blue: Ligands for E3 Ligase ligand (HY-D2259); Black: linker).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 3031840-31-7
화학식: C₄₇H₅₁ClN₁₀O₄S
분자량:887.49

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

NEP108 Chemical Structure

CAS No.: 3031840-31-7

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

NEP108 is a GID4 E3 ligase-based BRD4 PROTAC degrader, with its DC₅₀ value approximately 3.8 μM. NEP108 has a strong affinity for GID4, with a K_D value of 0.22 μM, and the K_D value of its trimeric complex is 2.85 μM. NEP108 can be used for cancer research^[1]. (Pink: BRD4 ligand (HY-78695); Blue: Ligands for E3 Ligase ligand (HY-D2259); Black: linker).

IC₅₀ & Target^[1]

BRD4

3.8 μM (DC₅₀)

All PROTACs Isoforms :

All Epigenetic Reader Domain Isoforms :

Chemical Information

CAS No. 3031840-31-7
분자량 887.49
화학식 C₄₇H₅₁ClN₁₀O₄S
SMILES

CC1=NN=C2[C@H](CC(NCCOCCOC3=CC4=C(C=C3)N=C([C@H]5CC[C@@H](NC(CNCC6=CC7=C(C=CC=C7)N6)=O)CC5)N4)=O)N=C(C8=CC=C(Cl)C=C8)C9=C(SC(C)=C9C)N12
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li Y, et al. Design of PROTACs utilizing the E3 ligase GID4 for targeted protein degradation. Nature Structural & Molecular Biology. 2025 Apr 28:1-3.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
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Purity:
수량:

NEP108

All PROTACs Isoforms

All Epigenetic Reader Domain Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

NEP108 Related Classifications

HY-180957 Related Classifications