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Cat. No.: HY-P2185

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NFF-3

NFF-3 is a MMP-3-selective fluorescent peptide substrate that is efficiently hydrolyzed by MMP-3. NFF-3 can be used in research related to MMP-3 enzyme activity detection.

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CAS No.: 158584-09-9
화학식: C₇₈H₁₁₀N₂₂O₂₀
분자량:1675.84

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

NFF-3 Chemical Structure

CAS No.: 158584-09-9

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

NFF-3 is a MMP-3-selective fluorescent peptide substrate that is efficiently hydrolyzed by MMP-3. NFF-3 can be used in research related to MMP-3 enzyme activity detection^[1]^[2]^[3].

IC₅₀ & Target

^[1]

MMP-3

All MMP Isoforms :

In Vitro

NFF-3 is a substrate that is rapidly hydrolyzed by MMP-3 in a continuous fluorescence assay^[1].
NFF-3 is hydrolyzed by MMP-3 with k_cat/K_m = 218,000 s^-1 M^-1, whereas MMP-1 and MMP-2 show no detectable hydrolysis, and MMP-9 exhibits much lower efficiency (10,100 s^-1 M^-1)^[2].
NFF-3 confers MMP-3-triggered degradability on chitosan microspheres (CNMS) in the bacterial infection microenvironment^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 158584-09-9
분자량 1675.84
화학식 C₇₈H₁₁₀N₂₂O₂₀
Sequence

{Mca}-Arg-Pro-Lys-Pro-Val-Glu-{Nva}-Trp-Arg-Lys(DNP)-NH2
Sequence Shortening

{Mca}-RPKPVE-{Nva}-WR-{K(DNP)}-NH2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cheng L, et al. Bioresponsive micro-to-nano albumin-based systems for targeted drug delivery against complex fungal infections. Acta pharmaceutica Sinica. B. 2021 Oct;11(10):3220-3230.

[2]. Nagase H, et al. Design and characterization of a fluorogenic substrate selectively hydrolyzed by stromelysin 1 (matrix metalloproteinase-3). The Journal of biological chemistry. 1994 Aug 19;269(33):20952-7.

[3]. Cheng D, et al. High-performance lung-targeted bio-responsive platform for severe colistin-resistant bacterial pneumonia therapy. Bioactive materials. 2024 May;35:517-533.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
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Purity:
수량:

NFF-3

All MMP Isoforms

Biological Activity

제품 설명

IC50 & Target

In Vitro

Chemical Information

순도&문서

References

Calculators

Help & FAQs

NFF-3 Related Classifications

HY-P2185 Related Classifications

Bioz

Keywords

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