Cat. No.: HY-N0292

Oleuropein

10 Cited Publications

고객리뷰

Based on 10 publication(s) in Google Scholar

Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity. Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 99.97%
CAS No.: 32619-42-4
화학식: C₂₅H₃₂O₁₃
분자량:540.51

보관:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Oleuropein Chemical Structure

CAS No.: 32619-42-4

사이즈

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- Clinical Trial
Chemical Information
Publications (10)
용액&용해도
- In Vitro
- In Vivo
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity^[1]. Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase^[2].

IC₅₀ & Target

PPARγ

Aromatase

Apoptosis

All Cytochrome P450 Isoforms :

All PPAR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
B16-F1	IC₅₀	283.9 μM Compound: 1	Antiproliferative activity against mouse B16-F1 cells after 72 hrs by MTT reduction assay Antiproliferative activity against mouse B16-F1 cells after 72 hrs by MTT reduction assay	[PMID: 28551177]
HCT-116	IC₅₀	181.86 μM Compound: 1	Antiproliferative activity against human HCT116 cells after 72 hrs by MTT reduction assay Antiproliferative activity against human HCT116 cells after 72 hrs by MTT reduction assay	[PMID: 28551177]
HeLa	IC₅₀	265.28 μM Compound: 1	Antiproliferative activity against human HeLa cells after 72 hrs by MTT reduction assay Antiproliferative activity against human HeLa cells after 72 hrs by MTT reduction assay	[PMID: 28551177]
HL-60	IC₅₀	54.26 μM Compound: 1	Antiproliferative activity against human HL60 cells after 72 hrs by MTT reduction assay Antiproliferative activity against human HL60 cells after 72 hrs by MTT reduction assay	[PMID: 28551177]
K562	IC₅₀	64.73 μM Compound: 1	Antiproliferative activity against human K562 cells after 72 hrs by MTT reduction assay Antiproliferative activity against human K562 cells after 72 hrs by MTT reduction assay	[PMID: 28551177]
MCF7	IC₅₀	161.57 μM Compound: 1	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT reduction assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTT reduction assay	[PMID: 28551177]
RAW264.7	IC₅₀	>80 μM Compound: 11	Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess reagent-based assay Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess reagent-based assay	[PMID: 32936639]
SK-BR-3	IC₅₀	160.44 μM Compound: 1	Antiproliferative activity against human SKBR3 cells after 72 hrs by MTT reduction assay Antiproliferative activity against human SKBR3 cells after 72 hrs by MTT reduction assay	[PMID: 28551177]

In Vitro

Aromatase, a cytochrome P450 enzyme, is an important pharmacological target in breast cancer therapy^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 32619-42-4
Appearance Solid
분자량 540.51
화학식 C₂₅H₃₂O₁₃
Color White to light yellow
SMILES

OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@](O[C@@H]2OC=C(C(OC)=O)[C@@H](CC(OCCC3=CC=C(O)C(O)=C3)=O)/C2=C\C)([H])O1
Structure Classification
- Terpenoids
- Iridoids
- Phenols
- Polyphenols
Initial Source
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (10)

All Cell Imaging/StainingIn Vivo ImagingBio/Physico-chemical Assay2D/3D Cell Culture and DifferentiationIn Vivo Efficacy Study

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Journal Impact Factor

Nat Commun

Aneuploid embryonic stem cells drive teratoma metastasis. [Abstract]

2024 Feb 5;15(1):1087. PMID: 38316790

Oleuropein purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Feb 5;15(1):1087. [Abstract]

IHC experiment detecting OCT4 expression in vehicle- or Oleuropein (0.5 μg/mL)-treated WT and aneuploid primary teratomas.

Oleuropein purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Feb 5;15(1):1087. [Abstract]

BLI imaging of distant organs from teratoma-bearing mice of different aneuploidy exposure to proteasome activator Oleuropein (20 mg/kg/day, i.p.).

Oleuropein purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Feb 5;15(1):1087. [Abstract]

Oleuropein (0.5 μg/mL) treatment could increase the proteasome activity in aneuploid cells to some extent.

Oleuropein purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Feb 5;15(1):1087. [Abstract]

In vitro EB differentiation of WT and aneuploid ESCs with or without Oleuropein (0.5 μg/mL) treatment.

Oleuropein purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Feb 5;15(1):1087. [Abstract]

Treatment with Oleuropein (20 mg/kg/day, i.p.) effectively reduced aneuploid teratoma volume.
Acta Pharm Sin B

Evidence that metformin promotes fibrosis resolution via activating alveolar epithelial stem cells and FGFR2b signaling. [Abstract]

2025 Sep;15(9):4711-4729. PMID: 41049730
Phytomedicine

Bruceantin inhibits the c-Myc/RL27A axis to suppress tumor progression in hepatocellular carcinoma. [Abstract]

2025 Dec 24:150:157740. PMID: 41477978
Phytomedicine

Daidzein reprograms EP300/CREBBP-deficient immune evasion via targeting the PPARγ-ANGPT4/Tie2 axis in hypopharyngeal squamous cell carcinoma. [Abstract]

2025 Dec:149:157488. PMID: 41240538
Cell Mol Life Sci

IL-38 attenuates vascular calcification by upregulating GPX3-mediated antioxidant defense via the PPAR-γ/NRF2 axis. [Abstract]

2025 Nov 27;83(1):19. PMID: 41307654
Cancer Gene Ther

Oleuropein regulates ubiquitination-mediated Mcl-1 turnover and exhibits antitumor activity. [Abstract]

2025 Jul;32(7):793-805. PMID: 40506561
Biomolecules

PPARs Activity Affects the Hatchability Through Lipid Metabolism Regulation in Silkworm, Bombyx mori L. [Abstract]

2025 Mar 27;15(4):492. PMID: 40305260
Theriogenology

Oleuropein restores oocyte competence during SIRT1 inhibition via SIRT1/NRF2-mediated redox and metabolic reprogramming in porcine oocytes. [Abstract]

2026 May:256:117873. PMID: 41698313
Tissue Cell

Oleuropein attenuates testicular ischemia-reperfusion by inhibiting apoptosis and inflammation. [Abstract]

2022 Oct:78:101876. PMID: 35914339
Nutraceuticals

2026 Jun;6(2):24.

용액&용해도

In Vitro:

DMSO : 125 mg/mL (231.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 20 mg/mL (37.00 mM)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.8501 mL

9.2505 mL

18.5010 mL

5 mM

0.3700 mL

1.8501 mL

3.7002 mL

10 mM

0.1850 mL

0.9251 mL

1.8501 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (3.85 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (3.85 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (3.85 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Svobodova M, et al. Oleuropein as an inhibitor of peroxisome proliferator-activated receptor gamma. Genes Nutr. 2014 Jan;9(1):376. [Content Brief]

[2]. Gorzynik-Debicka M, et al. Potential Health Benefits of Olive Oil and Plant Polyphenols. Int J Mol Sci. 2018 Feb 28;19(3). pii: E686. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	1.8501 mL	9.2505 mL	18.5010 mL	46.2526 mL
	5 mM	0.3700 mL	1.8501 mL	3.7002 mL	9.2505 mL
	10 mM	0.1850 mL	0.9251 mL	1.8501 mL	4.6253 mL
	15 mM	0.1233 mL	0.6167 mL	1.2334 mL	3.0835 mL
	20 mM	0.0925 mL	0.4625 mL	0.9251 mL	2.3126 mL
	25 mM	0.0740 mL	0.3700 mL	0.7400 mL	1.8501 mL
	30 mM	0.0617 mL	0.3084 mL	0.6167 mL	1.5418 mL
DMSO	40 mM	0.0463 mL	0.2313 mL	0.4625 mL	1.1563 mL
	50 mM	0.0370 mL	0.1850 mL	0.3700 mL	0.9251 mL
	60 mM	0.0308 mL	0.1542 mL	0.3084 mL	0.7709 mL
	80 mM	0.0231 mL	0.1156 mL	0.2313 mL	0.5782 mL
	100 mM	0.0185 mL	0.0925 mL	0.1850 mL	0.4625 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Oleuropein

10 Cited Publications

100 mg 견적 받기

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Oleuropein

Apoptosis Compound Library

Cell Cycle/DNA Damage Compound Library

Metabolism/Protease Compound Library

Natural Product Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Antioxidant Compound Library

Glycoside Compound Library

Oxygen Sensing Compound Library

Anti-Cardiovascular Disease Compound Library

Medicine Food Homology Compound Library

Terpenoids Library

Phenols Library

Traditional Chinese Medicine Active Compound Library

FDA Approved & Pharmacopeial Drug Library

Anti-Breast Cancer Compound Library

Anti-Obesity Compound Library

Mitochondria-Targeted Compound Library

Transcription Factor-Targeted Library

Lipid Metabolism Compound Library

Food-Sourced Compound Library

Anti-Cancer Natural Product Library

Plant-Sourced Natural Product Library

Human Metabolite Library

Nuclear Receptor Compound Library

Osteogenesis Compound Library

Anti-Aging Natural Product Library

Metabolic Enzyme Compound Library

Cell Death Library

Multi-Target Compound Library

Radioprotector Library

Bioactive Compound Library Max

Anti-Aging Compound Library Mini

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Anti-Fibrosis Compound Library

PBCRBS Traditional Chinese Medicine Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Flavor Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mass Spectrometry Human Metabolite Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Mongolian Medicine Compound Library

Natural Product Diversity Scaffold Library

Tonifying Traditional Chinese Medicine Monomer Compound Library

RNA Binding Bioactive Compound Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) Oleuropein

All Cytochrome P450 Isoforms

All PPAR Isoforms

Biological Activity

Chemical Information

Publications (10)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

Oleuropein Related Classifications

HY-N0292 Related Classifications