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Cat. No.: HY-N12503

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Patuletin

Patuletin is a flavonol, that can be isolated from the flowers of Tagetes patula. Patuletin shows anti-proliferative activity against cancer cells. Patuletin causes significant nuclear fragmentation and has a great capacity to induce caspase-3 activation.

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CAS No.: 519-96-0
화학식: C₁₆H₁₂O₈
분자량:332.26

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Patuletin Chemical Structure

CAS No.: 519-96-0

사이즈

가격

재고

수량

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

Caspase 3

All Caspase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	10.1 μg/mL Compound: 11	Antioxidant activity in human HL60 cells assessed as reduction of cytochrome-c release Antioxidant activity in human HL60 cells assessed as reduction of cytochrome-c release	[PMID: 10650074]

In Vitro

Patuletin (0-100 μg/mL, 24 h) shows anti-proliferative activity against cancer cells^[2].
Patuletin induces apoptosis in the CaSki, MDA-MB-231, and SK-Lu-1 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[2]

Cell Line:

CaSki, MDA-MB-231 and SK-Lu-1
Concentration:

6, 12, 25, 50 and 100 μg/mL
Incubation Time:

24 h
Result:

Showed a dose-dependent proliferation inhibition, with IC₅₀ values of 37, 86, and 18 μg/mL for CaSki, MDA-MB-231 and SK-Lu-1 cells, respectively.

Chemical Information

CAS No. 519-96-0
분자량 332.26
화학식 C₁₆H₁₂O₈
SMILES

O=C1C(O)=C(C2=CC(O)=C(O)C=C2)OC3=CC(O)=C(C(O)=C13)OC
Structure Classification
- Flavonoids
- Flavonols
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zane A , et al. Flavonols in Spinach Leaves[J]. Journal of Organic Chemistry, 1961, 26(11).

[2]. Alvarado-Sansininea JJ, et al. Quercetagetin and Patuletin: Antiproliferative, Necrotic and Apoptotic Activity in Tumor Cell Lines. Molecules. 2018 Oct 9;23(10):2579. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

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Patuletin

All Caspase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Patuletin Related Classifications

HY-N12503 Related Classifications