SLW131
Based on 1 publication(s) in Google Scholar
SLW131 is a CCR7 antagonist with a Ki value of 9.85 nM. SLW131 inhibits CCL19-induced Go protein activation with an IC50 of 29.4 μM, and suppresses β-arrestin2 recruitment with an IC50 of 6.0 μM. SLW131 serves as a probe for investigating the biological functions of CCR7 in cells. SLW131 is applicable to research related to rheumatoid arthritis.
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- CAS No.: 681511-84-2
- 화학식: C21H27N5O5S
- 분자량:461.53
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) SLW131
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Biological Activity
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CCR7 9.85 nM (Ki) |
Arrestin-3/β-Arrestin 2 6.0 μM (IC50) |
SLW131 (Compound 10) binds to the intracellular allosteric site of CCR7 in cell-free CCR7GSSGNluc membranes with a single-digit nanomolar affinity (Ki = 9.85 nM), showing 10-fold higher potency than Cmp2105[1].
SLW131 engages the intracellular allosteric site of CCR7 in live HEK293T cells transiently expressing CCR7GSSG_Nluc with a single-digit nanomolar affinity (Ki = 6.53 nM), demonstrating improved cellular target engagement compared to Cmp2105[1].
SLW131 inhibits CCL19-induced β-arrestin2 recruitment in HEK293T cells transiently expressing hCCR7, while Cmp2105 shows no inhibitory activity[1].
SLW131 (10 μM; 1 h) inhibits CCL19-directed 3D collagen migration of primary mature BMDCs, while Cmp2105 shows no inhibitory activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 681511-84-2
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분자량 461.53
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화학식 C21H27N5O5S
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SMILES
O=C(C1=CC=CC(NC(C(N[C@H](C(C)(C)C)C2=CC=C(O2)C)=N3)=NS3(=O)=O)=C1O)N(C)C
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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JCI Insight
ANGPTL8 links refeeding to monocyte dynamics and metabolic inflammation via the CCL5-CCR5 axis. [Abstract]2025 Nov 25:e196605. PMID: 41289013
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References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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