Copy Link Print Information

Tacrolimus monohydrate

(Synonyms: FK506 monohydrate; Fujimycin monohydrate; FR900506 monohydrate)
105 Cited Publications
고객리뷰

Based on 105 publication(s) in Google Scholar

Tacrolimus (FK506) monohydrate, a molecular glue, a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus monohydrate inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

  • Purity: 99.93%
  • CAS No.: 109581-93-3
  • 화학식: C44H71NO13
  • 분자량:822.03
  • 보관:

    4°C, protect from light

    * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

  • Tacrolimus monohydrate Chemical Structure
    Tacrolimus monohydrate Chemical Structure
  • Experimental Validation Results for Tacrolimus monohydrate
  • Experimental Validation Results for Tacrolimus monohydrate
  • Experimental Validation Results for Tacrolimus monohydrate
  • Experimental Validation Results for Tacrolimus monohydrate
  • Experimental Validation Results for Tacrolimus monohydrate
  • Experimental Validation Results for Tacrolimus monohydrate
  • Experimental Validation Results for Tacrolimus monohydrate
  • Experimental Validation Results for Tacrolimus monohydrate
  • Experimental Validation Results for Tacrolimus monohydrate
  • Experimental Validation Results for Tacrolimus monohydrate
  • Experimental Validation Results for Tacrolimus monohydrate
  • Experimental Validation Results for Tacrolimus monohydrate
CAS No.: 109581-93-3
사이즈
가격
재고
수량
Amount: USD 0.00
Please select quantity
or
or

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download
Other Forms of Tacrolimus monohydrate:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
주변의 대리점 찾기 Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Chemical Information
  • 용액&용해도
  • Protocol
  • 순도&문서
  • References
  • Help & FAQs
You May Still Need
Top Publications Citing

Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) Tacrolimus monohydrate

More
Customer Validation & Images
IFELISAFlow CytometryWB
  • ELISA
  • ELISA
  • ELISA
  • WB
  • IF
  • IF
  • IF
  • Flow Cytometry
  • WB
  • IF
  • WB
  • IF

All Antibiotic Isoforms

More
Keywords
100 mg

견적 받기 해외재고보유

Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress 로그인
Register
Sign in to MedChemExpress
회원가입

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • Tacrolimus monohydrate Chemical Structure
    Tacrolimus monohydrate Chemical Structure
    1/16
  • 1/16

    Tacrolimus monohydrate purchased from MedChemExpress. Usage Cited in: Toxics. 2024 Aug 19;12(8):607. [Abstract]

    Customer Validation
     Tacrolimus monohydrate (100 nM-10 µM) decreased IL-2 secretion from Jurkat cells and coculture with THP-1 cells.

  • 1/16

    Tacrolimus monohydrate purchased from MedChemExpress. Usage Cited in: Toxics. 2024 Aug 19;12(8):607. [Abstract]

    Customer Validation
     Tacrolimus monohydrate (100 nM-10 µM) caused significant TNFα inhibition in Jurkat cells and coculture with THP-1 cells.

  • 1/16

    Tacrolimus monohydrate purchased from MedChemExpress. Usage Cited in: Toxics. 2024 Aug 19;12(8):607. [Abstract]

    Customer Validation
     Tacrolimus monohydrate (100 nM-10 µM) significantly inhibited IL-8 secretion from THP-1, Jurkat cells and their coculture.

  • 1/16

    Tacrolimus monohydrate purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2023 Oct;56(10):e13460. [Abstract]

    Customer Validation
     FK506 (5 μM; 14 days) significantly inhibits the protein expression of both calcineurin A and NFATC2 in hLESCs.

  • 1/16

    Tacrolimus monohydrate purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2023 Oct;56(10):e13460. [Abstract]

    Customer Validation
     FK506 (5 μM; 14 days) inhibits WNT16b on hLESC cell proliferation.

  • 1/16

    Tacrolimus monohydrate purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2023 Oct;56(10):e13460. [Abstract]

    Customer Validation
     FK506 (5 μM; 14 days) significantly inhibits the expression of WNT16b-promoting cell proliferation marker Ki67 and the putative hLESC marker ΔNp63α in hLESCs.

  • 1/16

    Tacrolimus monohydrate purchased from MedChemExpress. Usage Cited in: SSRN. 2023 Oct 31.

    Customer Validation
     Tacrolimus monohydrate (FK506) (100 ng/mL) significantly increased the expressions of protein K14, CDH1 in kCSTA cells in an inflammatory environment.

  • 1/16

    Tacrolimus monohydrate purchased from MedChemExpress. Usage Cited in: SSRN. 2023 Oct 31.

    Customer Validation
     Tacrolimus monohydrate (FK506) (100 ng/mL) increased CSTA proteins in kCSTA cells.

  • 1/16

    Tacrolimus monohydrate purchased from MedChemExpress. Usage Cited in: Cell Biol Toxicol. 2022 Jun;38(3):487-504. [Abstract]

    Customer Validation
     FK506 inhibits dephosphorylation of Drp-1 at Ser637 site induced by CVB3 infection. CVB3 infection-induced decrease in Bcl-2 expression and enhanced levels of Bax and Caspase-3 cleavage are reversed by FK506.

  • 1/16

    Tacrolimus monohydrate purchased from MedChemExpress. Usage Cited in: J Extracell Vesicles. 2019 Dec 27;9(1):1709262. [Abstract]

    Customer Validation
     Exosomal PD-L1 suppressed T cell activation and promoted skin cell migration in vitro (a). Representative confocal image show the appearance of exosomes as small-red dots. (b-c). Representative confocal images of pre-stained exosomes (red) colocalized with cell membrane (green) of HEK 293T (b) and Jurkat T cells (c).

  • 1/16

    Tacrolimus monohydrate purchased from MedChemExpress. Usage Cited in: Brain Res. 2019 May 15:1711:68-76. [Abstract]

    Customer Validation
     Levels of CytC in cytosol (Cyto-CytC), CytC in mitochondria (Mito- CytC) and cleaved caspase-3 in hippocampus are determined by western blot with the treatment of sham, HIR, MDV or FK506.

  • 1/16

    Tacrolimus monohydrate purchased from MedChemExpress. Usage Cited in: Theranostics. 2018 Jan 1;8(4):878-893. [Abstract]

    Customer Validation
     Accumulation of immune cells in host mice. Immunofluorescent images of CD4+ cells (green) in transplanted site in the normal, E+R, E+R+T, and E+R+T-RNPs groups at day 7 and day 21.

  • Tacrolimus monohydrate