(+)-Theta-cypermethrin
(+)-Theta-cypermethrin is a stereoisomer of Cypermethrin (HY-B0829) that possesses blood-brain barrier penetration ability and binds to AKT1, SRC, STAT3 and EGFR with high affinity. (+)-Theta-cypermethrin reduces the amplitude of delayed rectifier potassium channel currents, shifts the steady-state activation curve to negative potentials, and shifts the steady-state inactivation curve to negative potentials at higher concentrations. (+)-Theta-cypermethrin induces abnormal electrical activity in rat hippocampal neurons. (+)-Theta-cypermethrin causes chronic respiratory system damage and exhibits neurotoxicity.
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- CAS No.: 65732-07-2
- 화학식: C22H19Cl2NO3
- 분자량:416.30
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Biological Activity
제품 설명
In Vitro
(+)-Theta-cypermethrin (10-9-10-7 M; applied via perfusion during electrophysiological recording) inhibits delayed rectifier potassium current (Ik) in rat hippocampal CA3 neurons in vitro in a concentration-dependent manner, reduces Ik amplitude by up to 53.28% at 10-7 M, shifts steady-state activation and inactivation curves toward negative potentials, and reduces the activation curve slope factor at 10-7 M[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 65732-07-2
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분자량 416.30
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화학식 C22H19Cl2NO3
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SMILES
C(O[C@H](C#N)C1=CC(OC2=CC=CC=C2)=CC=C1)(=O)[C@@H]3[C@@H](C=C(Cl)Cl)C3(C)C
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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Neurotoxicity Study
This protocol assesses in vitro neurotoxicity by combining neuronal viability, mitochondrial/metabolic activity, neurite outgrowth, and optional neuronal network function readouts. Calcein-AM or resazurin/PrestoBlue readouts estimate viable or metabolically active cells; βIII-tubulin immunofluorescence detects neuronal morphology and neurite networks; TMRE detects mitochondrial membrane potential; and MEA recordings detect functional changes in neuronal network activity.
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Primary Embryonic Hippocampal Neuron Culture
Primary embryonic hippocampal neuron culture is an in vitro method in which hippocampi from embryonic rodents are dissected, enzymatically or mechanically dissociated, plated on adhesive substrates, and maintained in defined neuronal medium or in low-density sandwich/co-culture formats to support neuronal attachment, neurite extension, polarity formation, dendritic arborization, and synapse formation. The main readouts are cell survival, neuronal purity, neurite outgrowth, axon-dendrite polarization, synaptic marker development, and functional neuronal activity, assessed by phase-contrast microscopy, immunocytochemistry for neuronal/glial markers, live imaging, or electrophysiology depending on the downstream experiment.
순도&문서
References
[1]. Tian YT, et al. Effect of alpha-cypermethrin and theta-cypermethrin on delayed rectifier potassium currents in rat hippocampal neurons. Neurotoxicology. 2009;30(2):269-273. [Content Brief]
[2]. Tian J, et al. Network toxicological mechanism analysis of pyrethroid insecticides-induced chronic respiratory system damage in humans. Ecotoxicol Environ Saf. 2025;303:118828. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(+)-Theta-cypermethrin Related Classifications
HY-W714853 Related Classifications
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