2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease MAPK/ERK Pathway Stem Cell/Wnt TGF-beta/Smad Immunology/Inflammation NF-κB
  3. PPAR ERK JNK TGF-beta/Smad NO Synthase COX NF-κB Interleukin Related
  4. Lobeglitazone sulfate

Lobeglitazone sulfate is a new type of thiazolidinedione. Lobeglitazone sulfate is the orally active agonist for PPAR with EC50 of 137.4 nM and 546.3 nM for PPARγ and PPARα. Lobeglitazone sulfate is the inhibitor for ERK/JNK/Smad/NF-κB signaling pathway. Lobeglitazone sulfate exhibits anti-inflammatory, anti-diabetic, anti-fibrotic and anti-atherosclerotic properties.

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Lobeglitazone sulfate

Lobeglitazone sulfate Estructura química

No. CAS : 763108-62-9

Tamaño Precio Stock Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Other Forms of Lobeglitazone sulfate:

Lobeglitazone sulfate Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas PPAR:

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PPARα PPARβ/δ PPARγ PPAR PPARδ

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ERK ERK1 ERK2 ERK5 ERK8

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JNK1 JNK2 JNK3 JNK

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nNOS iNOS eNOS

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COX COX-1 COX-2 COX-3

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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Descripciòn

Lobeglitazone sulfate is a new type of thiazolidinedione. Lobeglitazone sulfate is the orally active agonist for PPAR with EC50 of 137.4 nM and 546.3 nM for PPARγ and PPARα. Lobeglitazone sulfate is the inhibitor for ERK/JNK/Smad/NF-κB signaling pathway. Lobeglitazone sulfate exhibits anti-inflammatory, anti-diabetic, anti-fibrotic and anti-atherosclerotic properties[1][2][3][4][5][6].

IC50 & Target

PPARγ

137.4 nM (EC50)

PPARα

546.3 nM (EC50)

In Vitro

Lobeglitazone sulfate increases glucose uptake in 3T3-L1 adipocytes and L6 muscle cells[1].
Lobeglitazone sulfate (50-200 μM, 24 h) inhibits NO generation and the expressions of pro-inflammtory cytokines like IL-1β, IL-6, iNOS, COX-2 and MCP-1 in LPS (HY-D1056)-stimulated BMDMs[2].
Lobeglitazone sulfate (10 μM, 48 h) inhibits TGF-β1-induced expression of α-SMA and fibronectin, inhibits Smad signaling pathway in primary human corneal fibroblast, and exhibits anti-fibrotic property[3].
Lobeglitazone sulfate (1-15 μM, 24 h) inhibits PDGF-induced proliferation and migration of vascular smooth muscle cells (VSMCs), inhibits TNF-α-induced NF-κB p65 translocation[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lobeglitazone sulfate Related Antibodies

Real Time qPCR[2]

Cell Line: BMDM
Concentration: 50-200 µM
Incubation Time: 24 h
Result: Inhibited the expression of IL-1β, IL-6, iNOS, COX-2 and MCP-1.

Western Blot Analysis[2]

Cell Line: primary human corneal fibroblast
Concentration: 1-10 µM
Incubation Time: 48 h
Result: Inhibited expression of α-SMA and fibronectin.
In Vivo

Lobeglitazone sulfate (1-10 mg/kg, po for 8 weeks) exhibits anti-atherosclerotic property in ApoE / mouse models[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ApoE−/− mouse aortic atherosclerosis models[4]
Dosage: 1-10 mg/kg
Administration: po for 8 weeks
Result: Reduced aortic arch plaques.
Ensayo clínico
Peso molecular

578.61

Fòrmula

C24H26N4O9S2
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

O=C(SC1CC2=CC=C(C=C2)OCCN(C)C3=NC=NC(OC4=CC=C(C=C4)OC)=C3)NC1=O.O=S(O)(O)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad
In Vitro: 

DMSO : 25 mg/mL (43.21 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7283 mL 8.6414 mL 17.2828 mL
5 mM 0.3457 mL 1.7283 mL 3.4566 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7283 mL 8.6414 mL 17.2828 mL 43.2070 mL
5 mM 0.3457 mL 1.7283 mL 3.4566 mL 8.6414 mL
10 mM 0.1728 mL 0.8641 mL 1.7283 mL 4.3207 mL
15 mM 0.1152 mL 0.5761 mL 1.1522 mL 2.8805 mL
20 mM 0.0864 mL 0.4321 mL 0.8641 mL 2.1603 mL
25 mM 0.0691 mL 0.3457 mL 0.6913 mL 1.7283 mL
30 mM 0.0576 mL 0.2880 mL 0.5761 mL 1.4402 mL
40 mM 0.0432 mL 0.2160 mL 0.4321 mL 1.0802 mL
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Lobeglitazone sulfate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lobeglitazone763108-62-9PPARERKJNKTGF-beta/SmadNO SynthaseCOXNF-κBInterleukin RelatedPeroxisome proliferator-activated receptorsExtracellular signal regulated kinasesc-Jun N-terminal kinaseTransforming growth factor betaNitric oxide synthasesNOSCyclooxygenaseNuclear factor-κBNuclear factor-kappaBILtype 2 diabetes mellitusT2DMSprague Dawley ratA549atherosclerosisInhibitorinhibitorinhibit

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Nombre del producto:
Lobeglitazone sulfate
Cat. No.:
HY-14928A
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