NEP108
NEP108 is a GID4 E3 ligase-based BRD4 PROTAC degrader, with its DC50 value approximately 3.8 μM. NEP108 has a strong affinity for GID4, with a KD value of 0.22 μM, and the KD value of its trimeric complex is 2.85 μM. NEP108 can be used for cancer research.
(Pink: BRD4 ligand (HY-78695); Blue: Ligands for E3 Ligase ligand (HY-D2259); Black: linker).
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 3031840-31-7
- Fòrmula: C47H51ClN10O4S
- Peso molecular:887.49
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Help & FAQs
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
BRD4 3.8 μM (DC50) |
Chemical Information
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No. CAS 3031840-31-7
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Peso molecular 887.49
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Fòrmula C47H51ClN10O4S
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SMILES
CC1=NN=C2[C@H](CC(NCCOCCOC3=CC4=C(C=C3)N=C([C@H]5CC[C@@H](NC(CNCC6=CC7=C(C=CC=C7)N6)=O)CC5)N4)=O)N=C(C8=CC=C(Cl)C=C8)C9=C(SC(C)=C9C)N12
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NEP108 Related Classifications
HY-180957 Related Classifications
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