2. PROTAC Epigenetics
  3. PROTACs Epigenetic Reader Domain
  4. NEP108

NEP108 is a GID4 E3 ligase-based BRD4 PROTAC degrader, with its DC50 value approximately 3.8 μM. NEP108 has a strong affinity for GID4, with a KD value of 0.22 μM, and the KD value of its trimeric complex is 2.85 μM. NEP108 can be used for cancer research.
(Pink: BRD4 ligand (HY-78695); Blue: Ligands for E3 Ligase ligand (HY-D2259); Black: linker).

For research use only. We do not sell to patients.

NEP108

NEP108 Chemical Structure

CAS No. : 3031840-31-7

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NEP108 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

NEP108 is a GID4 E3 ligase-based BRD4 PROTAC degrader, with its DC50 value approximately 3.8 μM. NEP108 has a strong affinity for GID4, with a KD value of 0.22 μM, and the KD value of its trimeric complex is 2.85 μM. NEP108 can be used for cancer research[1]. (Pink: BRD4 ligand (HY-78695); Blue: Ligands for E3 Ligase ligand (HY-D2259); Black: linker).

IC50 & Target[1]

BRD4

3.8 μM (DC50)

Molecular Weight

887.49

Formula

C47H51ClN10O4S
CAS No.
SMILES

CC1=NN=C2[C@H](CC(NCCOCCOC3=CC4=C(C=C3)N=C([C@H]5CC[C@@H](NC(CNCC6=CC7=C(C=CC=C7)N6)=O)CC5)N4)=O)N=C(C8=CC=C(Cl)C=C8)C9=C(SC(C)=C9C)N12
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NEP108 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NEP1083031840-31-7NEP 108NEP-108PROTACsEpigenetic Reader DomainGID4 E3 ligasePROTACtargeted protein degradationBRD4ternary complexcrystal structureubiquitin-proteasome systemInhibitorinhibitorinhibit

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