(S)-JNJ-3738
(S)-JNJ-3738 is a CDK7 inhibitor. (S)-JNJ-3738 regulates kinase activity and exerts weak inhibitory effects on the activity of mutant CDK7. (S)-JNJ-3738 is applicable for cancer research.
For research use only. We do not sell to patients.
- CAS No.: 2796279-22-4
- Formula: C29H36N6O4S
- Molecular Weight:564.70
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CDK7 |
(S)-JNJ-3738 (Compound 150) inhibits wild-type CDK7 in A549 cells with pIC50 values of 6.5 and 6.34, but shows no significant activity against mutant hCDK7 in A549 cells[1].
(S)-JNJ-3738 (20 nM) is an irreversible inhibitor of purified CDK7 enzyme, with Ki values of 0.283192 μM and 0.179643 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2796279-22-4
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Molecular Weight 564.70
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Formula C29H36N6O4S
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SMILES
C[C@H]1C2=C(N3CCS(=O)(CC3)=O)N=CN=C2NC4=CC(C5CCN(C6CN(C6)C(C#CC)=O)CC5)=CC(C)=C4O1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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