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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
307 Results for "
Axis
" in MedChemExpress (MCE) Product Catalog:
Products (307)
307 Results for "Axis" in MCE Product Catalog:
3
3 Cited Publications
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3
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N6-Cyclohexyladenosine is a selective adenosine A1 receptor agonist (EC50 = 8.2 nM). N6-Cyclohexyladenosine enhances the activation of the PI3K/Akt/CREB/BDNF axis. N6-Cyclohexyladenosine promotes remyelination, induces sleep, and improves 3-NP-induced Huntington's disease. N6-Cyclohexyladenosine can be used in liver cancer research .
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3 Cited Publications
Synonyms: (-)-Eburnamonine; (-)-Vincamone
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Category:
Quinones Other Diseases Plants Other Families Extract Disease Research Fields Naphthalene Quinones Pteris livida Mett.
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2
2 Cited Publications
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2-APQC is an orally active and selective agonist of Sirtuin-3 (SIRT3) (Kd=2.756 μM), antagonizes Isoproterenol/ISO (HY-B0468)-induced cytotoxicity. 2-APQC activates the SIRT3-PYCR1 axis to enhance mitochondrial proline metabolism and inhibit the ROS-p38MAPK pathway by inhibiting signaling pathways such as mTOR-p70S6K, JNK, and TGF-β/Smad3. 2-APQC also activates the AMPK-Parkin axis to alleviate myocardial hypertrophy and fibrosis and protect cardiac function. 2-APQC can be used in the study of heart failure .
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2 Cited Publications
Cat. No.: HY-B0025
CAS No.: 83480-29-9
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2
2 Cited Publications
Cat. No.: HY-N1374
CAS No.: 31008-18-1
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Lignans Magnolia Liliflora Desr. Phenylpropanoids Plants Magnoliaceae Extract Disease Research Fields Inflammation/Immunology
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2
2 Cited Publications
Cat. No.: HY-N7043
CAS No.: 142796-21-2
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2 Cited Publications
Cat. No.: HY-N8107
CAS No.: 34446-06-5
2
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Et-29 (NRD167) is a selective SIRT5 inhibitor. Et-29 increases the levels of total protein succinylation and citrate synthase succinylation in cells. Et-29 reduces serum CTX-I levels and blocks Ferroptosis by downregulating the SIRT5/ACSL4/LPCAT3/ALOX15 axis and restoring antioxidant defense. Et-29 decreases bone resorption and improves trabecular bone mass and microarchitecture. Et-29 is applicable for research related to osteoporosis and hepatocellular carcinoma .
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2 Cited Publications
Cat. No.: HY-N0508
CAS No.: 85026-55-7
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Rhodiola rosea Linn. Simple Phenylpropanols Crassulaceae Extract Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology
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2 Cited Publications
Synonyms: (±)-Arabinose; DL-Arabinose; dl-Arabinose
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2 Cited Publications
Cat. No.: HY-N3389
CAS No.: 66056-19-7
2
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2
2 Cited Publications
Cat. No.: HY-N10549
CAS No.: 83088-28-2
1
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Cardiovascular Disease Rutaceae Extract Other Monoterpenes Microorganisms Terpenoids Plants Disease Research Fields Citrus
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1 Cited Publications
Cat. No.: HY-W015273A
CAS No.: 29953-71-7
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(E/Z)-BCI (NSC 150117) is a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory activities. (E/Z)-BCI attenuates LPS-induced inflammatory mediators and ROS production in macrophage cells via activating the Nrf2 signaling axis and inhibiting the NF-κB pathway .
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(R)-Nimodipine ((R)-BAY-e 9736) is an orally active, blood-brain barrier-permeable L-type calcium channel blocker with an IC50 of 5 nM. (R)-Nimodipine inhibits corticosterone release by blocking calcium channels on the hypothalamic-pituitary-adrenal axis, thereby reversing immobilization stress-induced memory impairment and behavioral abnormalities. (R)-Nimodipine is widely used in studies related to aneurysmal subarachnoid hemorrhage, cerebral ischemia, epilepsy, age-related degenerative neurological diseases, and alcohol intoxication .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
