Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1009 Results for "
G2
" in MedChemExpress (MCE) Product Catalog:
Products (1009)
1009 Results for "G2" in MCE Product Catalog:
5
5 Cited Publications
Cat. No.: HY-N0047
CAS No.: 50773-41-6
4
4 Cited Publications
Cat. No.: HY-N0712
CAS No.: 104472-68-6
4
4 Cited Publications
PHA-793887 is a CDK inhibitor (with IC50 values of 8 nM for Cdk2, 60 nM for Cdk1, 62 nM for Cdk4, 138 nM for Cdk9). PHA-793887 inhibits purified GSK3β (IC50 79 nM). PHA-793887 reduces the phosphorylation level of nucleophosmin/cdc6, induces G1/G2/M phase arrest, and triggers Apoptosis by activating Caspase-3. PHA-793887 exhibits anticancer activity against leukemia. PHA-793887 can be used in research related to acute leukemia, chronic myeloid leukemia, and advanced/metastatic solid tumors [2] .
3
3 Cited Publications
Synonyms: SNS-595; Vosaroxin; AG 7352
Target:
Research Areas:
Voreloxin (SNS-595; Vosaroxin; AG 7352) is a first-in-class topoisomerase II inhibitor that intercalates DNA and induces site-selective DNA DSB, G2 arrest, and apoptosis.
3
3 Cited Publications
Cat. No.: HY-16518
CAS No.: 175519-16-1
Synonyms: SNS-595 Hydrochloride; Vosaroxin Hydrochloride; AG 7352 Hydrochloride
Target:
Research Areas:
Voreloxin Hydrochloride is a first-in-class topoisomerase II inhibitor that intercalates DNA and induces site-selective DNA DSB, G2 arrest, and apoptosis.
3
3 Cited Publications
Target:
Research Areas:
ON1231320 is a highly specific polo like kinase 2 (PLK2) inhibitor with an IC50 of 0.31 μM. ON1231320 blocks tumor cell cycle progression in the G2/M phase in mitosis, causing apoptotic cell death. ON1231320, an arylsulfonyl pyrido-pyrimidinone, has antitumor activity [2].
3
3 Cited Publications
Target:
Research Areas:
Bractoppin is a potent and selective agent-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem(t) BRCT domain (binding IC50: 74 nM). Bractoppin diminishes BRCA1 recruitment to DNA breaks, in turn suppressing damage-induced G2 arrest and assembly of the recombinase, RAD51. Bractoppin preferentially inhibits BRCA1 tBRCT-dependent steps in the DNA damage response .
3
3 Cited Publications
PCC0208017 is a microtubule affinity regulating kinases (MARK3/MARK4) inhibitor with IC50s of 1.8 and 2.01 nM, respectively. PCC0208017 has much lower inhibitory activity against MARK1 and MARK2, with IC50s of 31.4 and 33.7 nM, respectively. PCC0208017 suppresses glioma progression in vitro and in vivo. PCC0208017 disrupts microtubule dynamics and induces G2/M phase cell cycle arrest and cell apoptosis. PCC0208017 demonstrates robust antitumor activity in vivo and displays good BBB permeability .
3
3
Category:
Quinones Other Diseases Plants Other Families Extract Disease Research Fields Naphthalene Quinones Pteris livida Mett.
Target:
3
3 Cited Publications
Cat. No.: HY-P74628
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PLA2G2A; Non-Pancreatic Secretory Phospholipase A2; Prev. PLA2B; Phospholipase A2; Prev. PLA2L; RASF-A; Phosphatidylcholine 2-Acylhydrolase 2A; PLA2S; Phospholipase A2, Membrane Associated; PLAS1; Group IIA Phospholipase A2; SPLA2; GIIC SPLA2; MOM1; Phosp
Species:
Mouse
Source:
P. pastoris
2
Target:
Research Areas:
Oxcarbazepine is a sodium channel blocker . Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines [2]. Anti-cancer and anticonvulsant effects [2] .
2
2 Cited Publications
Target:
Research Areas:
PCAF-IN-2 (compound 17) is a potent PCAF inhibitor with an IC50 value of 5.31 µM. PCAF-IN-2 shows anti-tumour activity. CAF-IN-2 induces apoptosis and arrest the cell cycle at the G2/M phase .
2
2 Cited Publications
Cat. No.: HY-W127705
CAS No.: 4213-45-0
2
2 Cited Publications
Cat. No.: HY-18643
CAS No.: 1002789-86-7
Target:
Research Areas:
TZ9 is a selective Rad6 inhibitor. TZ9 inhibits Rad6B-induced histone H2A ubiquitination, downregulates intracellular β-catenin, induces G2-M arrest and apoptosis, and inhibits the proliferation and migration of metastatic human breast cancer cells .
2
Category:
Infection Alkaloids Chelidonium majus Plants Disease Research Fields Isoquinoline Alkaloids Papaveraceae Extract
Target:
2
2
2 Cited Publications
Cat. No.: HY-N2447
CAS No.: 21018-84-8
2
Category:
Flavonoids Flavones Isatis tinctoria L. Phenols Polyphenols Cruciferae Extract Plants Disease Research Fields Cancer
Target:
2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
