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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2438 Results for "
decrease
" in MedChemExpress (MCE) Product Catalog:
Products (2438)
2438 Results for "decrease" in MCE Product Catalog:
Cat. No.: HY-181876
CAS No.: 3124701-00-1
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F44-S101 is an orally active, potent, and selective gut-restricted FXR antagonist with an IC50 of 0.48 μM and lipid-lowering activity. F44-S101 selectively antagonizes intestinal FXR, feedback-activates hepatic FXR, promotes cholesterol metabolism and reduces lipid accumulation. F44-S101 decreases total cholesterol, triglyceride and low-density lipoprotein cholesterol levels. F44-S101 can be used in studies related to hyperlipidemia .
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U-11634 is an orally active dopamine β-hydroxylase noncompetitive inhibitor, with rat LD50 values of 1197 mg/kg (subcutaneous) and 524 mg/kg (oral). U-11634 blocks conversion of dopamine to norepinephrine and reduces norepinephrine levels in brain. U-11634 decreases food intake and spontaneous motor activity via dietary inclusion. U-11634 induces thyroid toxicity and inhibits pregnancy. U-11634 inhibits deciduomata formation in intact and steroid-treated rats, with no reversal by progesterone or oestradiol. U-11634 can be used for pregnancy .
Cat. No.: HY-183328
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MNK1/2-IN-11 is a potent, selective and orally active MNK1/2 inhibitor with MNK1 IC50 of 1.2 nM, MNK2 IC50 of 1.3 nM. MNK1/2-IN-11 reduces eukaryotic translation initiation factor 4E phosphorylation, decreases Mcl-1 and Cyclin D1 expression. MNK1/2-IN-11 inhibits tumor growth in mouse CT26 colorectal tumor models. MNK1/2-IN-11 can be used for the research of colorectal cancer .
Cat. No.: HY-183404
CAS No.: 72807-01-3
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Wy 25093 is a selective serotonin (5-HT) uptake transporter inhibitor. Wy 25093 regulates the turnover and metabolism of central 5-HT, enhances postsynaptic 5-HT actions and 5-hydroxytryptophan-induced behavioral syndrome. Wy 25093 induces ipsilateral and contralateral circling behavior in rats, reduces the turnover rate of striatal dopamine, decreases the level of 5-hydroxyindole-3-acetic acid in the brain, and long-term administration reduces brain 5-HT levels. Wy 25093 can be used in research related to depression .
Cat. No.: HY-183611
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LPZ-51 is a Vibrio β-lactam resistance sensor kinase (VbrK) inhibitor with a Ki value of 1.09 μM. LPZ-51 inhibits blaA gene expression at the transcriptional level by blocking the kinase activity of VbrK, reduces β-lactamase synthesis, and does not affect bacterial growth. LPZ-51 acts synergistically with β-lactam antibiotics. LPZ-51 decreases bacterial load, alleviates intestinal inflammation, and improves survival rate in zebrafish infection models. LPZ-51 can be used in studies related to Vibrio parahaemolyticus infection .
Cat. No.: HY-187646
CAS No.: 2231259-57-5
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IACS-9439-Cl is a derivative of IACS-9439. IACS-9439 is an orally active and selective colony-stimulating factor 1 receptor (CSF1R) inhibitor with a Kd of 1 nM. IACS-9439-Cl reduces the population of tumor-associated macrophages. IACS-9439-Cl promotes the polarization of macrophages toward the M1 anti-tumor phenotype and decreases the M2 pro-tumor phenotype, thereby exerting a tumor growth inhibitory effect. IACS-9439-Cl can be used in cancer-related research .
Cat. No.: HY-189247
PRDX3-IN-1 is an orally active antagonist targeting mitochondrial PRDX3 (Kd=0.514 μM), where PRDX3 is a marker of ferroptosis. PRDX3-IN-1 causes PRDX3 inactivation and disrupts mitochondrial redox homeostasis, inducing apoptosis, ROS accumulation, and a decrease in mitochondrial membrane potential. PRDX3-IN-1 inhibits cell migration and invasion, and downregulates NF-κB and VEGF signaling pathways. PRDX3-IN-1 can be used for research on non-small cell lung cancer .
Cat. No.: HY-189501
CAS No.: 2569295-47-0
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MiZax5 is a zaxinone mimic and plant growth regulator (PGR) that negatively regulates strigolactone (SL) biosynthesis and release and promotes plant growth. MiZax5 downregulates the expression of SL biosynthesis-related genes D27, CCD7, CCD8, and carlactone oxidase, thereby reducing SL levels in rice roots and root exudates and further decreasing seed germination and emergence of the root parasitic plant Striga hermonthica. MiZax5 simultaneously promotes rice root growth and improves growth- and yield-related traits in various crops, making it useful for research related to plant growth regulation .
Cat. No.: HY-189674
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β2-adrenoceptor agonist 1 is a β2-adrenoceptor agonist with an EC50 of 7 pM. β2-adrenoceptor agonist 1 induces cAMP accumulation and airway/tracheal smooth muscle relaxation. β2-adrenoceptor agonist 1 inhibits inflammatory cell activity, reduces inflammatory cytokine production, and decreases mast cell infiltration. β2-adrenoceptor agonist 1 can be used for asthma research .
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Metaxalone (Standard) is the analytical standard of Metaxalone. This product is intended for research and analytical applications. Metaxalone (AHR438; NSC170959) is an FDA-approved muscle relaxant. Metaxalone acts mainly on the central nervous system and achieves muscle relaxation by inhibiting polysynaptic reflex arcs. In addition, Metaxalone is an inhibitor of MAO-A, which has anti-inflammatory and antioxidant effects. Metaxalone inhibits IL-1β-induced inflammatory phenotype, modulates NF-κB and other related signaling pathways, and decreases MAO-A expression and activity in IL-1β-treated microglia .
Cat. No.: HY-D1555
CAS No.: 2692677-77-1
Synonyms: Cy7 DBCO
Cat. No.: HY-D2062
CAS No.: 1448146-89-1
Cat. No.: HY-N19615
CAS No.: 134859-90-8
Cat. No.: HY-N20733
CAS No.: 69687-69-0
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NF-κB Akt PI3K TMV Apoptosis TNF Receptor Interleukin Related
Cat. No.: HY-N20748
CAS No.: 121817-37-6
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Cat. No.: HY-N21727
CAS No.: 1094030-07-5
Cat. No.: HY-N3807S
Cat. No.: HY-N4189
CAS No.: 17278-28-3
Cat. No.: HY-N6801
CAS No.: 23282-20-4
Category:
Infection Terpenoids Sesquiterpenes Microorganism Disease Research Fields Inflammation/Immunology
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
