1063 Results for "

Glycosides

" in MedChemExpress (MCE) Product Catalog:

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Baicalin

62 Publications Verification

Cat. No.: HY-N0197

CAS No.: 21967-41-9

Synonyms: Baicalein 7-O-β-D-glucuronide

Category:

Human Gut Microbiota Metabolites Flavonoids Flavones Labiatae Plants Endogenous metabolite Disease Research Fields Medicago truncatula Gaertn. Cancer

Target:

Carnitine Palmitoyltransferase (CPT) NF-κB Autophagy HIV

Baicalin, as a flavonoid glycoside, is an allosteric carnitine palmityl transferase 1 (CPT1) activator. Baicalin reduces the expression of NF-κB .

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Hesperidin

36 Cited Publications

Cat. No.: HY-15337

CAS No.: 520-26-3

Purity: 97.15%

Synonyms: Hesperetin 7-rutinoside

Category:

Flavonoids Anti-aging Flavonones Rutaceae Plants Endogenous metabolite Disease Research Fields Citrus Cancer

Target:

Apoptosis Autophagy Reactive Oxygen Species (ROS) Endogenous Metabolite

Hesperidin (Hesperetin 7-rutinoside), a flavanone glycoside, is isolated from citrus fruits. Hesperidin has numerous biological properties, such as decreasing inflammatory mediators and exerting significant antioxidant effects. Hesperidin also exhibits antitumor and antiallergic activities .

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Rutin trihydrate

34 Cited Publications

Cat. No.: HY-W013075

CAS No.: 250249-75-3

Synonyms: Rutoside trihydrate; Quercetin 3-O-rutinoside trihydrate

Category:

Flavonoids Flavones Combretaceae Combretum micranthum G. Don Plants

Target:

Apoptosis Endogenous Metabolite

Rutin (Rutoside) trihydrate is a multifunctional natural flavonoid glycoside. Rutin trihydrate has been demonstrating excellent antioxidant, anti-inflammatory, anti-diabetic, and anti-carcinogenic properties. Cardioprotective and neuroprotective activities .

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Icariin

29 Cited Publications

Cat. No.: HY-N0014

CAS No.: 489-32-7

Synonyms: Ieariline

Category:

Cardiovascular Disease Flavonols Anti-aging Plants Flavonoids Monophenols Phenols Epimedium brevicornu Maxim. Berberidaceae Disease Research Fields Inflammation/Immunology Cancer

Target:

Phosphodiesterase (PDE) PPAR Autophagy

Icariin is a flavonol glycoside. Icariin inhibits PDE5 and PDE4 activities with IC₅₀s of 432 nM and 73.50 μM, respectively. Icariin also is a PPARα activator.

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Naringin

27 Cited Publications

Cat. No.: HY-N0153

CAS No.: 10236-47-2

Synonyms: Naringoside

Category:

Citrus × aurantium Linnaeus Flavonoids Leguminosae Flavonones Rutaceae Plants Endogenous metabolite Disease Research Fields Glycyrrhiza uralensis Fisch. Cancer

Target:

Cytochrome P450 Autophagy Mitophagy Endogenous Metabolite

Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin also inhibits proliferation and invasion and induces apoptosis in human osteosarcoma cells by inhibiting zinc finger E-box binding homeobox 1 (Zeb1) .

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Digitonin

25 Cited Publications

Cat. No.: HY-N4000

CAS No.: 11024-24-1

Category:

Digitalis purpurea Linn. Scrophulariaceae Plants Disease Research Fields Cancer Steroids

Target:

Others

Digitonin, a glycoside obtained from Digitalis purpurea, could increase cell permeability by binding to cholesterol molecules and reduce tumor growth . Digitonin is an natural detergent .

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Catalpol

13 Cited Publications

Cat. No.: HY-N0820

CAS No.: 2415-24-9

Synonyms: Catalpinoside

Category:

Neurological Disease Anti-aging Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey Infection Iridoids Terpenoids Scrophulariaceae Disease Research Fields Inflammation/Immunology Cancer

Target:

HBV

Catalpol (Catalpinoside), an iridoid glycoside found in Rehmannia glutinosa. Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects .

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Poliumoside

11 Cited Publications

Cat. No.: HY-N0033

CAS No.: 94079-81-9

Category:

Cardiovascular Disease Callicarpa formosana Rolfe Plants Simple Phenylpropanols Verbenaceae Scrophulariaceae Phenols Polyphenols Phenylpropanoids Disease Research Fields Inflammation/Immunology Brandisia hancei Hook. f.

Target:

Aldose Reductase

Poliumoside, a caffeoylated phenylpropanoid glycoside, is isolated from Brandisia hancei stems and leaves. Poliumoside is an advanced glycation end product (AGE) formation and rat lens aldose reductase (RLAR) inhibitor, with IC₅₀s of 19.69 and 8.47 μM, respectively. Poliumoside also has antiinflammatory and antioxidant activity .

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Aucubin

11 Cited Publications

Cat. No.: HY-N0664

CAS No.: 479-98-1

Category:

Infection Eucommia ulmoides Oliver Neurological Disease Iridoids Terpenoids Eucommiaceae Plants Disease Research Fields Inflammation/Immunology

Target:

Bacterial

Aucubin is an iridoid glycoside component that acn be found in E. ulmoides. Aucubin can cross the blood-brain barrier (BBB) and has anti-anxiety, antidepressive and anti-neuroinflammatory effects. Aucubin has many biological activities, such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, anti-fibrotic, anti-cancer, hepatoprotective, neuroprotective and osteoprotective effects .

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Albiflorin

9 Cited Publications

Cat. No.: HY-N0037

CAS No.: 39011-90-0

Category:

Other Monoterpenes Paeonia lactiflora Pall. Terpenoids Plants Paeoniaceae Disease Research Fields Inflammation/Immunology

Target:

Reactive Oxygen Species (ROS)

Albiflorin, a major constituent contained in peony root, is a brain-penetrant monoterpene glycoside with neuroprotective effects. Albiflorin also has anti-inflammatory, antioxidant and antinociceptive effects .

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Engeletin

9 Cited Publications

Cat. No.: HY-N0436

CAS No.: 572-31-6

Category:

Plants Flavanonols Liliaceae Flavonoids Microorganisms Phenols Polyphenols Smilacis Glabrae Rhizoma Disease Research Fields Inflammation/Immunology

Target:

NF-κB

Engeletin is a flavanonol glycoside isolated from Smilax glabra Roxb. , inhibits NF-κB signaling-pathway activation, and possesses anti-inflammatory, analgesic, diuresis, detumescence, and antibiosis effects.

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Forsythiaside A

9 Cited Publications

Cat. No.: HY-N0028

CAS No.: 79916-77-1

Category:

Oleaceae Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Plants Forsythia suspensa (Thunb.) Vahl Disease Research Fields Inflammation/Immunology

Target:

Others

Forsythiaside A is an orally active phenylethanoid glycoside isolated from the dried fruits of Forsythia suspensa. Forsythiaside A is also an inhibitor of COX-2 and has anti-inflammatory, antioxidant and neuroprotective effects. Forsythiaside A prevents neuroinflammation and apoptosis caused by Aβ_25-35 damage and may be used in Alzheimer's disease (AD) research. Forsythiaside A also activates the Nrf2/HO-1 signaling pathway and inhibits OVA-induced asthma in mice. Forsythiaside A inhibits the interaction between KLRB1 and CLEC2D .

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Aloin-A

9 Cited Publications

Cat. No.: HY-N0123

CAS No.: 1415-73-2

Synonyms: Barbaloin-A

Category:

Quinones Liliaceae Anthraquinones Aloe vera (L.) Burm. f. Phenols Polyphenols Plants Disease Research Fields Cancer

Target:

Wnt

Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity. Aloin induces the differentiation of MC3T3-E1 cells into osteoblasts through MAPK-mediated Wnt and Bmp signaling pathways. Alkaline phosphatase (ALP) is an early marker of osteoblast differentiation, and the activity of ALP is also enhanced by Aloin. Aloin also reduces brain edema, reduces blood-brain barrier disruption and improves cortical impact injuries. Aloin is used in research into osteoporosis and traumatic brain injury (TBI) .

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Forsythoside B

8 Cited Publications

Cat. No.: HY-N0029

CAS No.: 81525-13-5

Category:

Oleaceae Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Plants Forsythia suspensa (Thunb.) Vahl Disease Research Fields Inflammation/Immunology

Target:

TNF Receptor NF-κB

Forsythoside B is a phenylethanoid glycoside isolated from Forsythia suspensa (Thunb.) Vahl, a Chinese folk medicinal plant for treating inflammatory diseases and promoting blood circulation. Forsythoside B could inhibit TNF-alpha, IL-6, IκB and modulate NF-κB.

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SL 0101-1

8 Cited Publications

Cat. No.: HY-15237

CAS No.: 77307-50-7

Purity: ≥98.0%

Synonyms: SL0101

Category:

Flavonols other families Flavonoids Pityrogramma triangularis Plants Disease Research Fields Cancer

Target:

Ribosomal S6 Kinase (RSK)

SL 0101-1 (SL0101), a kaempferol glycoside, isolated from the tropical plant F. refracta, is a cell-permeable, selective, reversible, ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor, with an IC₅₀ of 89 nM . SL 0101-1 (SL0101) is a selective RSK1/2 inhibitor, with a K_i of 1 μM .

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Afzelin

8 Cited Publications

Cat. No.: HY-N1441

CAS No.: 482-39-3

Synonyms: Kaempferol-3-O-rhamnoside

Category:

Flavonols Saururaceae Flavonoids Houttuynia cordata Thunb. Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:

Mitochondrial Metabolism PTEN Autophagy Bacterial

Afzelin (Kaempferol-3-O-rhamnoside)It is a flavonol glycoside that has anti-inflammatory, anti-oxidative stress response, anti-apoptotic, and anti-cardiac cytotoxic effects. AfzelinIt can reduce mitochondrial damage, enhance mitochondrial biosynthesis, and reduce mitochondria-related proteins. Parkinand PTENinduced putative kinase 1 (putative kinase 1)s level. AfzelinCan be improved D-galactosamine(GalN)/LPSSurvival rate of mice treated with doxorubicin prophylaxis (HY-15142A)Induced cardiotoxicity and scopolamine (HY-N0296)-induced neurological injury. AfzelinAlso inhibits asthma and allergies caused by ovalbumin .

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Lanatoside C

7 Cited Publications

Cat. No.: HY-B1030

CAS No.: 17575-22-3

Category:

other families Cardiacglycosides Plants Disease Research Fields Cancer Steroids

Target:

Flavivirus Dengue Virus Autophagy Enterovirus

Lanatoside C is a cardiac glycoside, can be used in the treatment of congestive heart failure and cardiac arrhythmia.Lanatoside C has an IC50 of 0.19 μM for dengue virus infection in HuH-7 cells. Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya, Sindbis virus and the human enterovirus 71 .

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Loganin

7 Cited Publications

Cat. No.: HY-N0512

CAS No.: 18524-94-2

Synonyms: Loganoside

Category:

Cornaceae Iridoids Cornus officinalis Sieb. et Zucc. Terpenoids Plants Disease Research Fields Cancer

Target:

Reactive Oxygen Species (ROS) TNF Receptor Interleukin Related

Loganin is a type of iridoid glycoside compound that possesses anti-inflammatory, antioxidant, and antitumor properties, and offers protective effects against acute lung injury and pulmonary fibrosis. Loganin exerts its protective effects against LPS (HY-D1056)-mediated inflammation and oxidative stress by upregulating the Nrf2/HO-1 signaling pathway, and it reduces neuroinflammation caused by spinal cord injury (SCI) .

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Cornuside

7 Cited Publications

Cat. No.: HY-N0631

CAS No.: 131189-57-6

Category:

Cornaceae Iridoids Cornus officinalis Sieb. et Zucc. Terpenoids Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:

Free Radical Scavengers p38 MAPK NF-κB JNK Cholinesterase (ChE) Acyltransferase NO Synthase Interleukin Related TNF Receptor Prostaglandin Receptor ERK COX

Cornuside is an iridoid glycoside with anti-allergic, anti-inflammatory, and neuroprotective activities. Cornuside exerts anti-allergic activity by downregulating the p38 MAPK, JNK, and NF-κB signaling pathways, and inhibits IgE-mediated histamine release from mast cells. Cornuside improves cognitive impairment in mice by inhibiting BACE1 activity (IC₅₀ = 55.84 μg/mL) and enhancing ChAT activity. Cornuside inhibits LPS (HY-D1056)-induced inflammatory mediators, including iNOS, COX-2, PGE2, TNF-α, IL-6, and IL-1β, by suppressing NF-κB activation .

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Oxypaeoniflorin

6 Cited Publications

Cat. No.: HY-N0748

CAS No.: 39011-91-1

Category:

Other Monoterpenes Monophenols Paeonia lactiflora Pall. Terpenoids Phenols Plants Paeoniaceae

Target:

Others

Oxypaeoniflorin, an anti-oxidant, is a monoterpene glycoside compound isolated from Paeoniae species. Oxypaeoniflorin has neuroprotective and anti-inflammatory effects .

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