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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
232 Results for "
L-type
" in MedChemExpress (MCE) Product Catalog:
Products (232)
232 Results for "L-type" in MCE Product Catalog:
19
19 Publications Verification
Synonyms: Ammoniated ruthenium oxychloride
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Ruthenium red (Ammoniated ruthenium oxychloride) is a polycationic dye widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria. Ruthenium red strongly reacts with phospholipids and fatty acids and binds to acidic mucopolysaccharides. Ruthenium red is a L-type calcium current (ICa) blocker. When using Ruthenium Red to stain plant tissue sections affected by pathogens, the breakdown of mucilaginous substances by the pathogens prevents them from taking up the stain, whereas the cell walls of healthy tissue stain red .
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17 Cited Publications
Cat. No.: HY-B0317
CAS No.: 88150-42-9
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Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer .
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17 Cited Publications
Cat. No.: HY-B0317B
CAS No.: 111470-99-6
Synonyms: Amlodipine benzenesulfonate
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Amlodipine besylate (Amlodipine benzenesulfonate), an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine besylate can be used for the research of high blood pressure and cancer .
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17 Cited Publications
Cat. No.: HY-B0317A
CAS No.: 88150-47-4
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Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer .
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Mibefradil dihydrochloride (Ro 40-5967 dihydrochloride) is a calcium channel blocker with moderate selectivity for T-type Ca 2+ channels (IC50s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively) .
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11 Cited Publications
Cat. No.: HY-B0632
CAS No.: 42399-41-7
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Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Diltiazem is a calcium antagonist and an L-type calcium channel inhibitor. Diltiazem inhibits Ca 2+ mobilization/influx, norepinephrine-induced contraction, and depolarization. Diltiazem produces coronary vasodilation and renal vasodilation; it inhibits sodium reabsorption in the distal nephron and increases urine flow, sodium and potassium excretion, Inulin (HY-N7075) and PAH clearance, and free water clearance. Diltiazem is used in research on cardiovascular diseases, kidney diseases, and inflammation .
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11 Cited Publications
Synonyms: (±)-Bay K 8644
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Bay K 8644 ((±)-Bay K 8644) is a racemate consisting of two isomers (R)-(+)-Bay-K-8644 and (S)-(-)-Bay-K-8644 . Bay K 8644 is a L-type Ca 2+ channel agonist with an EC50 of 17.3 nM. Bay K 8644 increases Ca 2+ influx through sarcolemmal Ca 2+ channels by increasing the open time of the channel. Bay K 8644 has vasoconstrictive effects .
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Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Diltiazem hydrochloride (CRD-401) is a calcium antagonist and an L-type calcium channel inhibitor. Diltiazem hydrochloride inhibits Ca 2+ mobilization/influx, norepinephrine-induced contraction, and depolarization. Diltiazem hydrochloride produces coronary vasodilation and renal vasodilation; it inhibits sodium reabsorption in the distal nephron and increases urine flow, sodium and potassium excretion, Inulin (HY-N7075) and PAH clearance, and free water clearance. Diltiazem hydrochloride is used in research on cardiovascular diseases, kidney diseases, and inflammation .
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9 Cited Publications
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(S)-(-)-Bay-K-8644 is an agonist of L-type Ca 2+ channel. (S)-(-)-Bay-K-8644 activates Ba 2+ currents (IBa) (EC50=32 nM).
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Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca 2+ channels, modulating non-selective cation channels (NSC), activating K + channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.
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6 Cited Publications
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5 Cited Publications
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Pinaverium bromide is an L-type calcium channel blocker with selectivity for the gastrointestinal tract, effectively relieves pain, diarrhea and intestinal discomfort, provides good therapeutic efficacies without significant adverse effects on Irritable bowel syndrome (IBS) patients .
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Dronedarone (SR 33589), a derivative of amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone is a substrate for and a moderate inhibitor of CYP3A4 .
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Umbelliferae/Apiaceae Extract Plant Monophenols Coumarins Phenols Phenylpropanoids Disease Research Fields Inflammation/Immunology Angelica sinensis (Oliv.) Diels Extract
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Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Azelnidipine (CS 905) is a dihydropyridine calcium channel blocker that is effective orally. Azelnidipine inhibits the intracellular calcium ion flow and lower blood pressure by selectively blocking L-type calcium channel on the membrane of vascular smooth muscle. Azelnidipine inhibits esophageal squamous cell carcinoma proliferation by targeting MEK1/2. Azelnidipine also has anti-inflammatory, antioxidant and neuroprotective effects .
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Cardiovascular Disease Alkaloids Plant Catharanthus roseus (L.) G. Don Extract Disease Research Fields Indole Alkaloids Apocynaceae Extract
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3 Cited Publications
Synonyms: (+)-3,4-Didehydrocoronaridine Tartrate
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Cardiovascular Disease Alkaloids Plant Catharanthus roseus (L.) G. Don Extract Disease Research Fields Cancer Indole Alkaloids Apocynaceae Extract
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3 Cited Publications
Cat. No.: HY-B0984
CAS No.: 13636-18-5
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Fendiline hydrochloride, a diphenylalkylamine type of antianginal agent, is an L-type calcium channel blocker (IC50 of 17 µM). Fendiline hydrochloride is also a selective K-Ras inhibitor, and has no effect on H-Ras and N-Ras. Fendiline hydrochloride inhibits K-Ras plasma membrane localization (IC50 of 9.64 μM), inhibits K-Ras signal output and blocks the proliferation of pancreatic, colon, lung, and endometrial cancer cell lines expressing oncogenic mutant K-Ras. Fendiline hydrochloride is a STING agonist and is able to inhibit the growth of multiple refractory cold tumors (MC38, CT26 and B16F10) .
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3 Cited Publications
Cat. No.: HY-B0984A
CAS No.: 13042-18-7
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Fendiline, a diphenylalkylamine type of antianginal agent, is an L-type calcium channel blocker (IC50 of 17 µM). Fendiline is also a selective K-Ras inhibitor, and has no effect on H-Ras and N-Ras. Fendiline inhibits K-Ras plasma membrane localization (IC50 of 9.64 μM), inhibits K-Ras signal output and blocks the proliferation of pancreatic, colon, lung, and endometrial cancer cell lines expressing oncogenic mutant K-Ras. Fendiline is a STING agonist and is able to inhibit the growth of multiple refractory cold tumors (MC38, CT26 and B16F10) .
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Isradipine (PN 200-110) is an orally active and blood-brain barrier permeability L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
