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Muscles

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1471

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4

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40

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126

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12

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Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P99355
    Bimagrumab
    3 Publications Verification

    Anti-ACVR2B Reference Antibody; BYM338

    		 TGF-β Receptor Metabolic Disease
    Bimagrumab (Anti-ACVR2B Reference Antibody) is a human monoclonal antibody that blocks activin type II receptor (ActRII), with KDs of 1.7 pM and 434 pM for human ActRIIB and ActRIIA, respectively. Bimagrumab can be used for the research of pathological muscle loss and weakness .
    Bimagrumab
  • HY-155673
    SLU-PP-332
    1 Publications Verification

    		 Estrogen Receptor/ERR Metabolic Disease
    SLU-PP-332 is a pan-Estrogen Receptor/ERR agonist with EC50 values of 98, 230 and 430 nM for ERRα, ERRβ and ERRγ, respectively. SLUPP-332 enhances mitochondrial function and cellular respiration in skeletal muscle cell lines. SLU-PP-332 has the potential to study metabolic diseases as well as improve muscle function .
    SLU-PP-332
  • HY-148799
    Sevasemten

    EDG-5506

    		 Myosin Others
    Sevasemten is an orally active, selective allosteric inhibitor of skeletal muscle myosin that protects skeletal muscle from contraction-induced injury. Sevasemten decreases muscle damage biomarkers and fibrosis while increasing muscle strength and activity in in Duchenne muscular dystrophy disease models .
    Sevasemten
  • HY-I1060
    L-Alloisoleucine
    1 Publications Verification

    (3R)-LS-Isoleucine

    		 Endogenous Metabolite Metabolic Disease
    L-Alloisoleucine is a stereoisomer of L-isoleucine. L-Alloisoleucine can be used in skeletal muscle research .
    L-Alloisoleucine
  • HY-B0740
    Cyclobenzaprine hydrochloride

    MK130 hydrochloride

    		 5-HT Receptor Parasite Infection Neurological Disease
    Cyclobenzaprine (MK130) hydrochloride is an orally active 5-HT2 receptor antagonist. Cyclobenzaprine hydrochloride acts centrally, providing skeletal muscle relaxation, alleviating muscle spasms, and reducing pain. Cyclobenzaprine hydrochloride also possesses antiparasitic activity. Cyclobenzaprine hydrochloride holds promise for research in the fields of acute, painful skeletal muscle disorders and infectious diseases .
    Cyclobenzaprine hydrochloride
  • HY-B0262
    Methocarbamol
    1 Publications Verification

    		 Sodium Channel Neurological Disease
    Methocarbamol is an orally active central muscle relaxant and blocks muscular Nav1.4 channel. Methocarbamol reversibly affects voltage dependence of inactivation of Nav1.4 channel. Methocarbamol has the potential for muscle spasms and pain syndromes research .
    Methocarbamol
  • HY-15259
    CP-640186
    5+ Cited Publications

    		 Acetyl-CoA Carboxylase Metabolic Disease
    CP-640186 is an orally active and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 can also stimulate muscle fatty acid oxidation .
    CP-640186
  • HY-P2807I
    L-Lactate Dehydrogenase, rabbit muscle

    		Lactate Dehydrogenase Others
    L-Lactate Dehydrogenase, rabbit muscle is a biological material or organic compound that can be used in life science research .
    L-Lactate Dehydrogenase, rabbit muscle
  • HY-Y0413
    Biacetyl monoxime

    Diacetyl monoxime; DAM

    		 Na+/K+ ATPase Myosin Cardiovascular Disease Metabolic Disease
    Biacetyl monoxime (Diacetyl monoxime), a myosin ATPase inhibitor, is a skeletal and cardiac muscle contraction inhibitor. Biacetyl monoxime is also a well-characterized non-competitive inhibitor of chemical and motile activity of skeletal muscle myosin-II. Biacetyl monoxime induces sarcoplasmic reticulum Ca 2+ release .
    Biacetyl monoxime
  • HY-148516
    MPH-220
    1 Publications Verification

    		 Myosin Neurological Disease
    MPH-220 is a selective and orally active inhibitor of skeletal muscle myosin-2. MPH-220 enables muscle relaxation. MPH-220 is anti-spastic agent that can be used in the research of spasticity and muscle stiffness .
    MPH-220
  • HY-P99370
    Landogrozumab
    1 Publications Verification

    LY2495655; Anti-GDF8 / Myostatin Reference Antibody (landogrozumab)

    		 TGF-beta/Smad Inflammation/Immunology Cancer
    Landogrozumab (LY2495655) is an humanized anti-myostatin monoclonal antibody. Landogrozumab effectively improves muscle volume, hand grip strength and function. Landogrozumab can be used for the research of muscle wasting disease .
    Landogrozumab
  • HY-B1901
    Eperisone hydrochloride

    (±)-Eperisone hydrochloride

    		 P2X Receptor Neurological Disease
    Eperisone Hydrochloride ((±)-Eperisone hydrochloride) is an orally active antispastic agent with a vasodilator effect, used for the research of muscle stiffness and pain. Eperisone Hydrochloride is a potent and selectively P2X7 receptor antagonist, also shows antagonism for human P2X3. Eperisone Hydrochloride works by relaxing both skeletal muscles and vascularsmooth muscles, demonstrating a variety of effects such as reduction ofmyotonia, improvement of circulationand and suppression of the pain reflex .
    Eperisone hydrochloride
  • HY-B1700A
    Mivacurium dichloride

    		nAChR Neurological Disease
    Mivacurium dichloride is a benzylisoquinoline derivative and is a short-acting non-depolarizing neuromuscular blocking agent and skeletal muscle relaxant. Mivacurium dichloride couples with the nAChR to reduce or inhibit the depolarizing effect of acetylcholine on the terminal disc of the muscle cell .
    Mivacurium dichloride
  • HY-107944
    Chlorphenesin carbamate

    Maolate; U 19646

    		 Drug Derivative Neurological Disease
    Chlorphenesin carbamate is a centrally acting skeletal muscle relaxant, as well as a derivate of Chlorphenesin (HY-A0133). Chlorphenesin carbamate can be used for the research of pain and discomfort related to skeletal muscle trauma and inflammation . Chlorphenesin carbamate is a selective blocker of polysynaptic pathways at the spinal and supra-spinal levels . Antinociceptive effect .
    Chlorphenesin carbamate
  • HY-P10646
    Muscle homing peptide M12

    		Biochemical Assay Reagents Neurological Disease
    Muscle homing peptide M12 can preferentially bind to surface protein of muscle cells. Muscle homing peptide M12 mediates enhanced cellular uptake of nanoparticles (NPs) in myoblasts in vitro. Muscle homing peptide M12 is covalently conjugated to PLGA-PEG NPs via the N-terminal α-amino groups of peptides using the N-hydroxysuccinimide ester reaction .
    Muscle homing peptide M12
  • HY-15259A
    CP-640186 hydrochloride
    5+ Cited Publications

    		 Acetyl-CoA Carboxylase Metabolic Disease
    CP-640186 hydrochloride is an orally active and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 hydrochloride can also stimulate muscle fatty acid oxidation .
    CP-640186 hydrochloride
  • HY-14290A
    Pinacidil monohydrate
    4 Publications Verification

    P-1134 monohydrate

    		 Potassium Channel Cardiovascular Disease
    Pinacidil (P-1134) monohydrate is a potent activator of ATP-sensitive potassium channel. Pinacidil monohydrate is an antihypertensive agent hyperpolarizes vascular smooth muscle by opening K + channels. Pinacidil monohydrate enhances K +-efflux in smooth muscle. Pinacidil monohydrate has vasorelaxant properties. Pinacidil monohydrate is able to inhibit spontaneous tone and of reducing agonist induced contractions. Pinacidil monohydrate can be studied in research area such as cardiovascular diseases .
    Pinacidil monohydrate
  • HY-P10476
    Myostatin inhibitory peptide 2

    		TGF-beta/Smad Others
    Myostatin inhibitory peptide 2 (compd 2) is a myostatin inhibitor with a Kd of 35.9 nM. Myostatin inhibitory peptide 2 can be used for researches of muscle atrophic disorders .
    Myostatin inhibitory peptide 2
  • HY-158183
    NMD670

    		Chloride Channel Neurological Disease
    NMD670 is an orally active inhibitor of skeletal muscle specific chloride channel ClC-1 with an EC50 of 1.6 μM. NMD670 enhances neuromuscular transmission and improves muscle contraction and strength. NMD670 can be used in the study of muscle weakness and muscle fatigue .
    NMD670
  • HY-B0570
    Decamethonium Bromide
    1 Publications Verification

    		 nAChR Neurological Disease
    Decamethonium Bromide is an acetylcholine receptor inhibitor and muscle relaxant. Decamethonium Bromide first induces depolarization of skeletal muscles, and then binds to postsynaptic acetylcholine receptors to induce persistent paralysis .\n
    Decamethonium Bromide
  • HY-B1343
    Pridinol mesylate

    		Cholinesterase (ChE) Neurological Disease
    Pridinol mesylate is an orally active, blood-brain permeable, muscarinic acetylcholine receptor (mAChR)-directed muscle relaxant. Pridinol mesylate reduces the conduction of impulses to spinal motor neurons and exerts muscle relaxant activity. Pridinol mesylate inhibits skeletal muscle contractures in diseases of both central and peripheral origin and can be used in research in the field of musculoskeletal diseases .
    Pridinol mesylate
  • HY-152697
    2-Methyladenosine
    1 Publications Verification

    		 Nucleoside Antimetabolite/Analog Others
    2-Methyladenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) .
    2-Methyladenosine
  • HY-126112
    Mephenoxalone

    		Drug Derivative Neurological Disease
    Mephenoxalone is a muscle relaxant with anti-anxiety activity. Mephenoxalone has neuropharmacologic activity in vivo. Mephenoxalone inhibits neuron transmission and can relax skeletal muscles by inhibiting the reflex arc .
    Mephenoxalone
  • HY-P99818
    Ramatercept

    ACE-031

    		 TGF-β Receptor Metabolic Disease
    Ramatercept (ACE-031) is a soluble ActRIIB receptor and can be used as a soluble activin receptor 2 (ACVR2) antagonist. Ramatercept inhibits the signal pathway of muscle growth inhibition and has potential application in muscle atrophy .
    Ramatercept
  • HY-W184800
    MuRF1-IN-2

    		Bacterial E1/E2/E3 Enzyme Inflammation/Immunology
    MuRF1-IN-2 (Example 3) is a MuRF1 inhibitor. MuRF1-IN-2 can be used for research of muscle wasting conditions, of skeletal or cardial muscle atrophy .
    MuRF1-IN-2
  • HY-112821
    IBS008738
    3 Publications Verification

    		 YAP Inflammation/Immunology
    IBS008738 is a potent TAZ activator. IBS008738 stabilizes TAZ, increases the unphosphorylated TAZ level, enhances the association of MyoD with the myogenin promoter, upregulates MyoD-dependent gene transcription, and competes with myostatin in C2C12 cells. IBS008738 enhances myogenesis in C2C12 cells and facilitates muscle repair in a muscle injury model .
    IBS008738
  • HY-B1901R
    Eperisone hydrochloride (Standard)

    (±)-Eperisone hydrochloride (Standard)

    		 P2X Receptor Reference Standards Neurological Disease
    Eperisone (hydrochloride) (Standard) is the analytical standard of Eperisone (hydrochloride). This product is intended for research and analytical applications. Eperisone Hydrochloride ((±)-Eperisone hydrochloride) is an orally active antispastic agent with a vasodilator effect, used for the research of muscle stiffness and pain. Eperisone Hydrochloride is a potent and selectively P2X7 receptor antagonist, also shows antagonism for human P2X3. Eperisone Hydrochloride works by relaxing both skeletal muscles and vascularsmooth muscles, demonstrating a variety of effects such as reduction ofmyotonia, improvement of circulationand and suppression of the pain reflex .
    Eperisone hydrochloride (Standard)
  • HY-W008552
    2-Iodoadenosine

    		Nucleoside Antimetabolite/Analog Cancer
    2-Iodoadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) .
    2-Iodoadenosine
  • HY-152702
    2,8-Dimethyladenosine

    		Nucleoside Antimetabolite/Analog Others
    2,8-Dimethyladenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) .
    2,8-Dimethyladenosine
  • HY-152812
    2-Chloro-2′-β-C-methyladenosine

    		Nucleoside Antimetabolite/Analog Others
    2-Chloro-2′-β-C-methyladenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) .
    2-Chloro-2′-β-C-methyladenosine
  • HY-B1283
    Mephenesin

    		iGluR Neurological Disease
    Mephenesin is an NMDA receptor antagonist. Mephenesin is also a central muscle relaxant with antianxiety, muscle-paralyzing and anticonvulsant effects. Mephenesin acts directly on the skeletal muscle fibres to produce skeletal muscle relaxation. Mephenesin is promising for research of spasticity or painful muscle spasm .
    Mephenesin
  • HY-P2734
    Phosphorylase a, rabbit muscle

    		Phosphatase Others
    Phosphorylase a, rabbit muscle is glycogen phosphorylase isolated from rabbit muscle. Phosphorylase a, rabbit muscle catalyzes glycogenolysis, converting glycogen and inorganic phosphate into glucose-1-phosphate to supply energy for muscle contraction .
    Phosphorylase a, rabbit muscle
  • HY-148516A
    (R)-MPH-220

    		Myosin Neurological Disease
    (R)-MPH-220 is the R isomer of MPH-220 (HY-148516). MPH-220 is a selective and orally active inhibitor of skeletal muscle myosin-2. MPH-220 enables muscle relaxation. MPH-220 is anti-spastic agent that can be used in the research of spasticity and muscle stiffness .
    (R)-MPH-220
  • HY-P2807J
    L-Lactate Dehydrogenase (L-LDH), pig muscle

    		Lactate Dehydrogenase Metabolic Disease
    L-Lactate Dehydrogenase (L-LDH), pig muscle is an L-lactate dehydrogenase found in pig muscle, mainly present in anaerobic tissues (skeletal muscle, red blood cells). L-Lactate Dehydrogenase (L-LDH), pig muscle can interact with acidic liposomes at low pH, causing protein to adsorb onto the liposomes and inhibit enzyme activity. The IC50 values for L-Lactate Dehydrogenase (L-LDH), pig muscle are 0.05 μM for cardiolipin and 1.3 μM for phosphatidylserine liposomes .
    L-Lactate Dehydrogenase (L-LDH), pig muscle
  • HY-121340
    Emylcamate

    		Others Neurological Disease
    Emylcamate is a potent muscle relaxant. Emylcamate has the potential for the research of neurological diseases .
    Emylcamate
  • HY-152834
    8-Methoxyadenosine

    		Nucleoside Antimetabolite/Analog Cancer
    8-Methoxyadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) .
    8-Methoxyadenosine
  • HY-152312
    8-Allyloxyadenosine

    		Nucleoside Antimetabolite/Analog Others
    8-Allyloxyadenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) .
    8-Allyloxyadenosine
  • HY-152637
    2-Benzylthioadenosine

    		Nucleoside Antimetabolite/Analog Cancer
    2-Benzylthioadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) .
    2-Benzylthioadenosine
  • HY-137311
    (S)-Albuterol hydrochloride

    		Calcium Channel Phospholipase mAChR Neurological Disease
    (S)-Albuterol hydrochloride is a muscarinic receptor and phospholipase C activator. (S)-Albuterol hydrochloride increases intracellular free calcium in airway smooth muscle .
    (S)-Albuterol hydrochloride
  • HY-152511
    8-Methylthio-adenosine

    		Nucleoside Antimetabolite/Analog Others
    8-Methylthio-adenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) .
    8-Methylthio-adenosine
  • HY-154523
    2-(4-Cyanobenzyl)thioadenosine

    		Nucleoside Antimetabolite/Analog Cancer
    2-(4-Cyanobenzyl)thioadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) .
    2-(4-Cyanobenzyl)thioadenosine
  • HY-152565
    N6-Aminoadenosine

    		Nucleoside Antimetabolite/Analog Others
    N6-Aminoadenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) .
    N6-Aminoadenosine
  • HY-100945
    Nitrocaramiphen hydrochloride

    		mAChR Neurological Disease
    Nitrocaramiphen hydrochloride is a selective M1 receptor antagonist (Ki: 5.5 nM). Nitrocaramiphen Hydrochloride inhibits the hyperpolarizing effect of muscarine in the muscle fibers .
    Nitrocaramiphen hydrochloride
  • HY-154796
    2-Methoxy-2’-deoxyadenosine

    		Nucleoside Antimetabolite/Analog Cancer
    2-Methoxy-2’-deoxyadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) .
    2-Methoxy-2’-deoxyadenosine
  • HY-B1343A
    Pridinol

    		Cholinesterase (ChE) Neurological Disease
    Pridinol is an orally active, blood-brain permeable, muscarinic acetylcholine receptor (mAChR)-directed muscle relaxant. Pridinol reduces the conduction of impulses to spinal motor neurons and exerts muscle relaxant activity. Pridinol inhibits skeletal muscle contractures in diseases of both central and peripheral origin and can be used in research in the field of musculoskeletal diseases .
    Pridinol
  • HY-W748379
    Fenyramidol

    (±)-Phenyramidol

    		 Drug Derivative Neurological Disease
    Fenyramidol is an Aminopyridine derivative. Fenyramidol can be used as a moderately potent, non-narcotic muscle relaxant with concomitant analgesic activity .
    Fenyramidol
  • HY-N8628
    3,4,5-Triiodobenzoic acid

    3,4,5-TIBA

    		 Phytohormone Others
    3,4,5-Triiodobenzoic acid is an auxin transport inhibitor. 3,4,5-Triiodobenzoic acid stimulates specific [ 3H]verapamil binding to zucchini microsomes. 3,4,5-Triiodobenzoic acid also increases specific [ 3H]verapamil binding to rabbit skeletal muscle membranes. 3,4,5-Triiodobenzoic acid can be used in the research of smooth muscle contraction .
    3,4,5-Triiodobenzoic acid
  • HY-B1343R
    Pridinol mesylate (Standard)

    		Reference Standards Cholinesterase (ChE) Neurological Disease
    Pridinol mesylate (Standard) is the analytical standard of Pridinol mesylate (HY-B1343). This product is intended for research and analytical applications. Pridinol mesylate is an orally active, blood-brain permeable, muscarinic acetylcholine receptor (mAChR)-directed muscle relaxant. Pridinol mesylate reduces the conduction of impulses to spinal motor neurons and exerts muscle relaxant activity. Pridinol mesylate inhibits skeletal muscle contractures in diseases of both central and peripheral origin and can be used in research in the field of musculoskeletal diseases .
    Pridinol mesylate (Standard)
  • HY-B0262R
    Methocarbamol (Standard)

    		Reference Standards Sodium Channel Neurological Disease
    Methocarbamol (Standard) is the analytical standard of Methocarbamol. This product is intended for research and analytical applications. Methocarbamol is an orally active central muscle relaxant and blocks muscular Nav1.4 channel. Methocarbamol reversibly affects voltage dependence of inactivation of Nav1.4 channel. Methocarbamol has the potential for muscle spasms and pain syndromes research .
    Methocarbamol (Standard)
  • HY-174145
    GLUT4 activator 3

    		GLUT Metabolic Disease
    GLUT4 activator 3 (Compound 13a) is an antidiabetic agent targeting GLUT4 translocation in skeletal muscle. GLUT4 activator 3 can promote the translocation of glucose transporter 4 (GLUT4) in skeletal muscle cells. GLUT4 activator 3 reduces blood glucose in STZ-induced diabetic rats .
    GLUT4 activator 3

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