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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
273 Results for "
P65
" in MedChemExpress (MCE) Product Catalog:
Products (273)
273 Results for "P65" in MCE Product Catalog:
162
162 Publications Verification
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JSH-23 is an NF-κB inhibitor which inhibits NF-κB transcriptional activity with an IC50 of 7.1 μM in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. JSH-23 inhibits nuclear translocation of NF-κB p65 without affecting IκBα degradation .
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37 Cited Publications
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SC75741 is a broad and efficient NF-κB inhibitor with an IC50 of 200 nM for p65 . SC75741 blocks influenza viruses (IV) replication. SC75741 impairs DNA binding of the NF-κB subunit p65, resulting in reduced expression of cytokines, chemokines, and pro-apoptotic factors. SC75741 subsequently inhibits caspase activation and blocks caspase-mediated nuclear export of viral ribonucleoproteins .
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Infection Acanthaceae Extract Simsia foetida (Cav.) S.F.Blake Terpenoids Diterpenoids Plants Disease Research Fields Inflammation/Immunology
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24 Cited Publications
Synonyms: β-Sitosterol (purity>98%); 22,23-Dihydrostigmasterol (purity>98%)
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17 Cited Publications
Synonyms: (-)-Epicatechol; Epicatechin; epi-Catechin
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Anti-aging Plants Camellia sinensis (L.) O. Ktze. Endogenous metabolite Theaceae Extract Flavonoids Sunscreen Flavanols Phenols Polyphenols Cosmetic Research Disease Research Fields Inflammation/Immunology Cancer
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17 Cited Publications
Synonyms: Crategolic acid; 2α-Hydroxyoleanolic acid
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Xanthones Phenols Polyphenols Anemarrhena asphodeloides Bunge Plants Liliaceae Extract Disease Research Fields Cancer
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16 Cited Publications
Cat. No.: HY-16657
CAS No.: 163847-77-6
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TAPI-1 is a broad-spectrum MMP inhibitor and NF-κB p65 inhibitor that targets ADAM17/TACE, ADAM10 and other proteins. TAPI-1 reduces the proteolytic cleavage of membrane-bound TNF-α, decreases TNF-α levels, inhibits NF-κB pathway activation, and downregulates profibrotic markers. TAPI-1 reduces the proportion of proinflammatory immune cells, alleviates cardiac and airway fibrosis, and improves cardiac function after myocardial infarction. Meanwhile, TAPI-1 inhibits the viability, migration and invasion of esophageal squamous cell carcinoma cells, enhances the chemosensitivity of Cisplatin (HY-17394), induces apoptosis, and shows low toxicity to normal esophageal epithelial cells. TAPI-1 can be widely used in studies related to myocardial infarction-induced heart failure, severe traumatic tracheal stenosis, esophageal squamous cell carcinoma and other conditions .
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12 Cited Publications
Cat. No.: HY-N0373
CAS No.: 58749-23-8
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Flavones Metabolic Disease Plants Brassicaceae Extract Phyllanthus Flavonoids Phenols Polyphenols Disease Research Fields Coronopus didymus Euphorbiaceae Extract
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Terpenoids Sesquiterpenes Plants Other Families Extract Disease Research Fields Inflammation/Immunology
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6 Cited Publications
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IAXO-102 is a TLR4 antagonist which negatively regulates TLR4 signalling. IAXO-102 inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdominal aortic aneurysm development .
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Lonicera japonica Thunb. Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Plants Caprifoliaceae Extract Disease Research Fields Cancer
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5 Cited Publications
Cat. No.: HY-N4187
CAS No.: 144506-15-0
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
