309 Results for "

RAW cell

" in MedChemExpress (MCE) Product Catalog:
Products (309)

309 Results for "RAW cell" in MCE Product Catalog:

23
Beta-Sitosterol (purity>98%)
Beta-Sitosterol (purity>98%)
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23 Publications Verification
Cat. No.: HY-N0171A
CAS No.: 83-46-5
Synonyms: β-Sitosterol (purity>98%); 22,23-Dihydrostigmasterol (purity>98%)
Category:  

Cardiovascular Disease Leguminosae Glycine max (L.) merr Plants Disease Research Fields Inflammation/Immunology Steroids

Target:  

Bacterial Apoptosis Reactive Oxygen Species (ROS) MDM-2/p53 Caspase PARP MMP Bcl-2 Family HIF/HIF Prolyl-Hydroxylase TNF Receptor Interleukin Related NF-κB mTOR Lactate Dehydrogenase CDK Glutathione Peroxidase SOD

Beta-Sitosterol (purity>98%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc .
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16
Indolelactic acid
Indolelactic acid
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16 Cited Publications
Cat. No.: HY-113099
CAS No.: 1821-52-9
Purity:  99.99%
Synonyms: Indole-3-lactic acid
Category:  

Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite

Indolelactic acid (Indole-3-lactic acid) is a tryptophan (Trp) catabolite in Azotobacter vinelandii cultures. Indolelactic acid has anti-inflammation and potential anti-viral activity .
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8
ML115
ML115
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8 Cited Publications
Cat. No.: HY-111152
CAS No.: 912798-42-6
Purity:  99.89%
Target:  

STAT

Research Areas:  

Cancer

ML115, a molecular probe of the signal transducer, is a selective STAT3 agonist, with an EC50 of 2 nM. ML115 increases the expression of BCL3, a known STAT3-dependent oncogene. ML115 is inactive against the related STAT1, STAT5 and NF-κB anti-targets. ML115 counteracts the effects of Ginsenoside Rc (HY-N0042) on cell viability and inflammatory responses in LPS (HY-D1056)-stimulated H9c2 and RAW264.7 cells, while altering oxidative stress markers. ML115 can be used for the study of breast and prostate cancers .
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5
Formamide
Formamide
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5 Cited Publications
Cat. No.: HY-Y0842
CAS No.: 75-12-7
Synonyms: Methanamide; Formimidic acid
Category:  

Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields

Target:  

Biochemical Assay Reagents

Formamide is an effective DNA denaturant that significantly reduces the stability of DNA in buffer solutions. Formamide can also be used as a decalcifying agent for rat cardiac cells. Additionally, formamide is widely used as a solvent or chemical raw material for ion compounds, resins, and plasticizers.
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5
Formamide (deionized)
Formamide (deionized)
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5 Cited Publications
Cat. No.: HY-Y0842B
CAS No.: 75-12-7
Synonyms: Methanamide (deionized); Formimidic acid (deionized)
Formamide deionized (Methanamide deionizde) is an effective DNA denaturant that significantly reduces the stability of DNA in buffer solutions. Formamide deionized can also be used as a decalcifying agent for rat cardiac cells. Additionally, Formamide deionized is widely used as a solvent or chemical raw material for ion compounds, resins, and plasticizers .
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5
Telithromycin
Telithromycin
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5 Cited Publications
Cat. No.: HY-A0062
CAS No.: 191114-48-4
Synonyms: HMR3647; RU66647
Target:  

Bacterial Antibiotic

Research Areas:  

Infection Inflammation/Immunology

Telithromycin (HMR3647) is a novel ketolide antibiotic that structurally resembles macrolides. Telithromycin belongs to the ketolide family that is characterized by a keto group at position 3 of the macrolide ring and is active against bacteria causing community-acquired pneumonia, acute exacerbation of chronic bronchitis, and acute sinusitis. Telithromycin also has similar immunomodulatory effects as macrolides. Telithromycin can be used for the research of respiratory infections including bronchial asthma .
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4
Amoxapine
Amoxapine
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4 Cited Publications
Cat. No.: HY-B0991
CAS No.: 14028-44-5
Synonyms: CL-67772
Target:  

Bacterial Autophagy

Research Areas:  

Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology

Amoxapine (CL-67772) is a norepinephrine reuptake blocker and a 5-HT2/5-HT3 antagonist. Amoxapine can be used for the research of depression. Amoxapine has antibacterial activity. Amoxapine can enhance the killing effect of macrophages on mycobacterium by inducing autophagy, while protecting the cells from death .
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4
NFATc1-IN-1
NFATc1-IN-1
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4 Cited Publications
Cat. No.: HY-147369
CAS No.: 1912422-56-0
Purity:  99.97%
Target:  

Nuclear Factor of activated T Cells (NFAT)

Research Areas:  

Others

NFATc1-IN-1 (compound A04) is a potent inhibitor of RANKL-induced osteoclast formation, with an IC50 of 1.57 μM. NFATc1-IN-1 shows anti-osteoclastogenic effects through reducing the RANKL-induced nuclear translocation of NFATc1. NFATc1-IN-1 can be used for osteoclastic diseases research .
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3
Sanggenon C
Sanggenon C
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3 Cited Publications
Cat. No.: HY-N0617
CAS No.: 80651-76-9
Category:  

Cardiovascular Disease Plants Moraceae Flavanonols Flavonoids Phenols Polyphenols Disease Research Fields Inflammation/Immunology Morus alba Linn.

Target:  

Phosphatase ERK NF-κB Apoptosis

Sanggenon C, a flavonoid, exerts protective effects against cardiac hypertrophy and fibrosis via suppression of the calcineurin/NFAT2 pathway. Sanggenon C inhibits mitochondrial fission to induce apoptosis by blocking the ERK signaling pathway. Sanggenon C inhibits inducible nitric oxide synthase expression in RAW264.7 cells, and TNF-α-stimulated cell adhesion and VCAM-1 expression, by suppressing NF-κB activity. Sanggenon C possesses antioxidant, anti-inflammatory and antitumor activities .
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3
Ergolide
Ergolide
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3 Cited Publications
Cat. No.: HY-N6893
CAS No.: 54999-07-4
Category:  

Phyllodium pulchellum (L.) Desv. Ketones, Aldehydes, Acids Plants Compositae Disease Research Fields Inflammation/Immunology Piptanthus nepalensis (Hook.) D. Don

Target:  

NF-κB NOD-like Receptor (NLR) Apoptosis Autophagy

Ergolide is an orally active dual inhibitor targeting NF-κB/p65 and NLRP3. Ergolide blocks the NF-κB signaling pathway and the nuclear translocation of p65, and irreversibly binds to the NACHT domain of NLRP3 to inhibit inflammasome assembly. Ergolide significantly reduces the production of inflammatory mediators (e.g., NO, PGE2) and cytokines, induces cancer cell apoptosis, autophagy and ROS generation. Ergolide also enhances the anti-tumor effect of vincristine. Ergolide alleviates acute lung injury via an NLRP3-dependent mechanism, and effectively improves the survival rate and behavioral function of septic mice and inflammatory zebrafish models. Ergolide is used in the research of metastatic uveal melanoma, neurodegenerative diseases (such as Alzheimer's disease, Parkinson's disease), sepsis and acute lymphoblastic leukemia .
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2
Madecassic acid
Madecassic acid
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2 Cited Publications
Cat. No.: HY-N0569
CAS No.: 18449-41-7
Category:  

Triterpenes Terpenoids Centella asiatica (L.) Urb. Plants Umbelliferae Disease Research Fields Inflammation/Immunology

Target:  

NO Synthase COX TNF Receptor Interleukin Related

Madecassic acid is isolated from Centella asiatica (Umbelliferae). Madecassic acid has anti-inflammatory properties caused by iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-κB activation in RAW 264.7 macrophage cells .
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2
Ophiopogonin D
Ophiopogonin D
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2 Cited Publications
Cat. No.: HY-N0515
CAS No.: 945619-74-9
Category:  

Cardiovascular Disease Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Plants Disease Research Fields Steroids

Target:  

PPAR NF-κB Calcium Channel Reactive Oxygen Species (ROS) ERK

Ophiopogonin D can be isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside. Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca 2+ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D can inhibit isteoclastic differentiation in RAW264.7 cells. Ophiopogonin D has protective effect as an antioxidant in H2O2-induced endothelial injury. Ophiopogonin D blocks ERK signaling cascades. Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice. Ophiopogonin D has been used against inflammatory, metabolic and cardiovascular diseases .
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2
Flavokawain B
Flavokawain B
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2 Cited Publications
Cat. No.: HY-N2132
CAS No.: 1775-97-9
Synonyms: Flavokavain B
Category:  

other families Flavonoids Chalcones Monophenols Phenols Plants Disease Research Fields Cancer

Target:  

Apoptosis Caspase PARP Bcl-2 Family NF-κB PI3K Akt p38 MAPK MMP Reactive Oxygen Species (ROS)

Flavokawain B (Flavokavain B) is an orally active chalcone. Flavokawain B results in activation of caspase-9, -3 and -8, cleavage of PARP. Flavokawain B down-regulates Bcl-2 with concomitant increase in Bax level. Flavokawain B inhibits NF-κB, PI3K/Akt and MAPK signaling pathway. Flavokawain B exhibits Apoptotic effects. Flavokawain B inhibits MMP-9 and promotes ROS generation. Flavokawain B inhibits multiple tumors and inflammation .
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2
Flavonol
Flavonol
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2 Cited Publications
Cat. No.: HY-107825
CAS No.: 577-85-5
Purity:  99.92%
Category:  

Flavonols Flavonoids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Bacterial Cholinesterase (ChE)

Flavonol is a cholinesterase (ChE) inhibitor, with an IC50 value of 120 μM and a Ki value of 74 μM. Flavonol has antioxidant, free radical-scavenging, antibacterial properties, and immune modulation functions. Flavonol inhibits the PriA helicase of Staphylococcus aureus. Flavonol can suppress the production of NO in LPS-activated RAW 264.7 cells by inhibiting the expression of the iNOS enzyme. Flavonol shows protective and analgesic effects in mice through various neuronal pathways. Flavonol can be used in research related to tumors and atherosclerosis diseases .
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2
Brazilein
Brazilein
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2 Cited Publications
Cat. No.: HY-N10424
CAS No.: 600-76-0
Category:  

Leguminosae Caesalpinia sappan L. Pigments Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology Food Research

Target:  

Na+/K+ ATPase Apoptosis Interleukin Related NO Synthase Bacterial Parasite

Brazilein is a compound with anti-inflammatory and neuroprotective activities, with an IC50 of 500 μM against guinea pig Na +,K +-ATPase. Brazilein reduces iNOS mRNA expression, thereby inhibiting nitric oxide production in immune cells. Brazilein suppresses inflammatory responses by reducing the mRNA expression of TNF-α and IL-6, but has no effect on IL-1β expression. Brazilein reduces the cerebral infarction volume and improves the neurological function scores of rats with cerebral ischemia-reperfusion injury. Brazilein induces apoptosis of splenic lymphocytes in mice. Brazilein inhibits humoral immune responses in mice, and causes thymus and spleen atrophy as well as body weight loss in mice. Brazilein also possesses antimalarial and antibacterial activities. Brazilein is also a red dye. Brazilein can be used in studies related to the infection, nervous system, cardiovascular system and inflammatory diseases .
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2
Pectolinarigenin
Pectolinarigenin
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2 Cited Publications
Cat. No.: HY-N0493
CAS No.: 520-12-7
Category:  

Flavonoids Flavones Campylotropis hirtella (Franch.) Schindl. Phenols Polyphenols Plants Compositae Disease Research Fields Inflammation/Immunology

Target:  

COX Lipoxygenase NF-κB p38 MAPK ERK HIF/HIF Prolyl-Hydroxylase Keap1-Nrf2 PI3K Apoptosis Autophagy

Pectolinarigenin is an orally active dual inhibitor of COX-2/5-LOX with anti-inflammatory, antioxidant, antitumor and neuroprotective activities. Pectolinarigenin exerts neuroprotective and anti-inflammatory effects on astrocyte inflammation via the NFκB and MAPK pathways. Pectolinarigenin inhibits LPS-induced phosphorylation of ERK1/2, N-FκB and p38MAPK, directly inhibits the enzymatic activity or binding of COX-2, 5-LOX and HIF-1α, and reduces the level of XIAP. Pectolinarigenin modifies Keap1 to promote nuclear accumulation of Nrf2, induces ARE-mediated antioxidant enzyme expression, and possesses direct free radical scavenging activity. Pectolinarigenin reduces the release of NO, proinflammatory mediators and leukotrienes, and increases the level of IL-10. Pectolinarigenin induces G2/M cell cycle arrest, apoptosis (Apoptosis) and autophagy (Autophagy) via the PI3K/AKT/mTOR signaling pathway. Pectolinarigenin reduces renal crystal deposition and inhibits melanin synthesis. Pectolinarigenin inhibits inflammation and alleviates allergy in mouse models of inflammation. Pectolinarigenin alleviates renal injury, inflammation and oxidative stress in mice by inhibiting HIF-1α activity. Pectolinarigenin can be used for the research of neurodegenerative diseases, inflammatory/allergic diseases, calcium oxalate nephrocalcinosis, gastric cancer, melasma, post-inflammatory diseases and chloasma .
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1
Cimifugin
Cimifugin
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1 Cited Publications
Cat. No.: HY-N0634
CAS No.: 37921-38-3
Synonyms: Cimitin
Category:  

Ranunculaceae Coumarins Phenylpropanoids Plants Cimicifuga racemosa (L.) Nutt. Disease Research Fields Inflammation/Immunology

Target:  

NF-κB

Cimifugin (Cimitin) is a bioactive component of Cimicifuga racemosa, a Chinese herb. Cimifugin suppresses allergic inflammation by reducing epithelial derived initiative key factors via regulating tight junctions . Cimifugin reduces the migration and chemotaxis of RAW264.7 cells and inhibits the release of inflammatory factors and activation of MAPKs and NF-κB signaling pathways induced by LPS .
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1
Coniferaldehyde
Coniferaldehyde
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1 Cited Publications
Cat. No.: HY-N2535
CAS No.: 458-36-6
Synonyms: 4-Hydroxy-3-methoxycinnamaldehyde
Category:  

other families Monophenols Simple Phenylpropanols Phenols Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology

Target:  

Keap1-Nrf2 Apoptosis

Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities .
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1
Dactylorhin A
Dactylorhin A
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1 Cited Publications
Cat. No.: HY-125531
CAS No.: 256459-34-4
Purity:  98.22%
Category:  

Bletilla striata (Thunb. ex Murray) Rchb. f. Orchidaceae Ketones, Aldehydes, Acids Other Diseases Plants Disease Research Fields

Target:  

Others

Dactylorhin A, a succinate derivative ester, is isolated from rhizomes of Gymnadenia conopsea. Dactylorhin A exhibits moderate inhibitory effects on NO production effects in RAW 264.7 macrophage cells .
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H-Val-Tyr-OH
H-Val-Tyr-OH
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1 Cited Publications
Cat. No.: HY-W009338
CAS No.: 3061-91-4
Synonyms: Val-Tyr
Category:  

Monophenols Ketones, Aldehydes, Acids Metabolic Disease Phenols Endogenous metabolite Disease Research Fields

Target:  

IKK NF-κB

H-Val-Tyr-OH (Val-Tyr) is a dipeptide formed by the connection of valine and tyrosine via a peptide bond. H-Val-Tyr-OH is a potential IKKα inhibitor and can be used in the research of cancer and inflammatory diseases .
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