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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
262 Results for "
TLR4
" in MedChemExpress (MCE) Product Catalog:
Products (262)
262 Results for "TLR4" in MCE Product Catalog:
616
Target:
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.
536
536 Cited Publications
Synonyms: TAK-242; CLI-095
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor. Resatorvid inhibits NO, TNF-α and IL-6 production with IC50s of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy and plays pivotal role in various inflammatory diseases .
22
22 Cited Publications
Cat. No.: HY-P1439
CAS No.: 1449566-36-2
Target:
Research Areas:
22
22 Cited Publications
Cat. No.: HY-P1439A
Target:
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15
15 Cited Publications
Target:
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TLR4-IN-C34 is an orally active TLR4 inhibitor and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis .
14
14 Cited Publications
Target:
Research Areas:
TH1020 is a potent and selective toll-like receptor 5 (TLR5)/flagellin complex antagonist with an IC50 of 0.85 μM. TH1020 inhbits flagellin-induced TLR5 signaling. TH1020 is inactive against TLR2, TLR3, TLR4, TLR7 and TLR8 .
13
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10
10 Cited Publications
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Sparstolonin B acts as a selective TLR2 and TLR4 antagonist and selectively blocks TLR2- and TLR4-mediated inflammatory signaling. Sparstolonin B has anti-HIV and anticancer activities .
9
9 Cited Publications
Cat. No.: HY-N0625A
CAS No.: 36052-37-6
Category:
Alpinia katsumadai Hayata Zingiberaceae Extract Plants Flavonoids Monophenols Flavonones Phenols Disease Research Fields Inflammation/Immunology Cancer
Target:
8
8 Cited Publications
Cat. No.: HY-N0795
CAS No.: 20315-25-7
Category:
Plants Other Families Extract Flavonoids Functional Molecules Research of Health Products Phenols Polyphenols Disease Research Fields Inflammation/Immunology Biflavones
Target:
8
8 Cited Publications
Cat. No.: HY-N0703
CAS No.: 51938-32-0
7
Category:
Flavonols Flavonoids Leguminosae Extract Plants Vigna unguiculata Disease Research Fields Inflammation/Immunology
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7
7 Cited Publications
Cat. No.: HY-N0405
CAS No.: 28608-75-5
Target:
6
6 Cited Publications
Target:
Research Areas:
IAXO-102 is a TLR4 antagonist which negatively regulates TLR4 signalling. IAXO-102 inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdominal aortic aneurysm development .
6
6 Cited Publications
Target:
Research Areas:
ABR-238901 is an orally active and potent S100A8/A9 blocker and inhibits S100A8/A9 interaction with its receptors RAGE (receptor for advanced glycation endproducts) and TLR4 (toll-like receptor 4). ABR-238901 has the potential for myocardial infarction (MI) research .
6
Target:
Environmental Pollutants FXR Calcium Channel Toll-like Receptor (TLR) SOD Reactive Oxygen Species (ROS) DNA/RNA Synthesis Interleukin Related NF-κB TNF Receptor Apoptosis
Research Areas:
Tris(2-chloroethyl) phosphate (TCEP) is a widely used organic phosphorus flame retardant, mainly used as a plasticizer. Tris(2-chloroethyl) phosphate has orally active hepatotoxicity, inducing an increase in reactive oxygen species (ROS) and calcium ions (Ca 2+) influx, a decrease in mitochondrial membrane potential (△Ψm), and causing DNA damage and cell apoptosis. Tris(2-chloroethyl) phosphate directly binds to FXR, inducing obesity and the formation of fatty liver in mice. Chloroethyl) phosphate activates the TLR4/NF-κB pathway, triggering liver inflammation .
6
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.
5
5 Cited Publications
Cat. No.: HY-N0201
CAS No.: 73069-13-3
Category:
Terpenoids Sesquiterpenes Astragalus caprinus L. Plants Compositae Extract Disease Research Fields Cancer
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5
5 Cited Publications
Target:
Research Areas:
MyD88-IN-1 (Compound c17) is an orally active MyD88 inhibitor. MyD88-IN-1 inhibits the interaction of TLR4 and MyD88 and suppressed the NF-κB pathway. MyD88-IN-1 can be used in research of cancer and inflammatory .
4
Category:
Monophenols Coumarins Phenols Acanthopanax senticosus (Rupr. et Maxim.) Harms Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology Araliaceae Extract
Target:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
