10415 Results for "

liquid-phase peptide synthesis

" in MedChemExpress (MCE) Product Catalog:

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450

Puromycin

450 Publications Verification

Cat. No.: HY-B1743

CAS No.: 53-79-2

Synonyms: CL13900

Category:

Infection Alkaloids Microorganisms Other Alkaloids Disease Research Fields

Target:

Bacterial Antibiotic Parasite

Puromycin dihydrochloride is the dihydrochloride salt of puromycin. Puromycin is an aminoglycoside antibiotic that inhibits protein synthesis.

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450

Puromycin dihydrochloride

450 Publications Verification

Cat. No.: HY-B1743A

CAS No.: 58-58-2

Synonyms: CL13900 dihydrochloride

Category:

Infection Microorganisms Antibiotics Resistance Selection Disease Research Antibacterial Disease Research Fields Other Antibiotics

Target:

Bacterial Antibiotic Parasite

Puromycin dihydrochloride (CL13900 dihydrochloride), an aminonucleoside antibiotic, inhibits protein synthesis .

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268

740 Y-P

268 Cited Publications

Cat. No.: HY-P0175

CAS No.: 1236188-16-1

Synonyms: 740YPDGFR; PDGFR 740Y-P

Target:

PI3K Autophagy

Research Areas:

Cancer

740 Y-P (740YPDGFR; PDGFR 740Y-P) is a potent and cell-permeable PI3K activator. 740 Y-P readily binds GST fusion proteins containing both the N- and C- terminal SH2 domains of p85 but fails to bind GST alone .

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259

Angiotensin II human

259 Cited Publications

Cat. No.: HY-13948

CAS No.: 4474-91-3

Purity: 99.98%

Synonyms: Angiotensin II; Ang II; DRVYIHPF

Category:

Natural Products Endogenous metabolite Disease Research Fields Endocrinology Cancer

Target:

Angiotensin Receptor Apoptosis

Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

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259

Angiotensin II human acetate

259 Cited Publications

Cat. No.: HY-13948A

CAS No.: 68521-88-0

Purity: 99.62%

Synonyms: Angiotensin II acetate; Ang II acetate; DRVYIHPF acetate

Target:

Angiotensin Receptor Apoptosis

Research Areas:

Cardiovascular Disease Infection Metabolic Disease Inflammation/Immunology Cancer

Angiotensin II human (Angiotensin II) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human acetate plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human acetate also induces apoptosis. Angiotensin II human acetate induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

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259

Angiotensin II human TFA

259 Cited Publications

Cat. No.: HY-13948B

CAS No.: 2761969-44-0

Purity: 98.84%

Synonyms: Angiotensin II TFA; Ang II TFA; DRVYIHPF TFA

Target:

Angiotensin Receptor Apoptosis

Research Areas:

Cardiovascular Disease Metabolic Disease Cancer

Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human TFA induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human TFA also induces apoptosis. Angiotensin II human TFA induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

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217

Bleomycin hydrochloride

217 Cited Publications

Cat. No.: HY-17565A

CAS No.: 67763-87-5

Target:

DNA/RNA Synthesis Antibiotic

Research Areas:

Cancer

Bleomycin hydrochloride is a DNA synthesis inhibitor. Bleomycin hydrochloride is a DNA damaging agent. Bleomycin hydrochloride is an antitumor antibiotic .

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217

Bleomycin sulfate

217 Cited Publications

Cat. No.: HY-17565

CAS No.: 9041-93-4

Synonyms: Bleomycin sulfate

Category:

Microorganisms Antibiotics Resistance Selection Mammalian Cell Culture Disease Research Anticancer Disease Research Fields Other Antibiotics Cancer

Target:

DNA/RNA Synthesis Antibiotic

Bleomycin sulfate is a DNA synthesis inhibitor. Bleomycin hydrochloride is a DNA damaging agent. Bleomycin sulfate is an antitumor antibiotic .

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216

Cyclosporin A

216 Cited Publications

Cat. No.: HY-B0579

CAS No.: 59865-13-3

Synonyms: Cyclosporine A; Ciclosporin A; CsA

Category:

Natural Products Microorganisms Anti-aging Disease Research Fields Inflammation/Immunology Cancer

Target:

Molecular Glues Complement System Antibiotic Cyclophilin

Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM . Cyclosporin A is a molecular glue, binds to cyclophilin and calcineurin, leading to inactivation of nuclear Factor of activated T Cells (NFAT) and a subsequent decrease in the immune response. Cyclosporin A also inhibits CD11a/CD18 adhesion .

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175

TGF beta 1/TGFB1 Protein, Human (CHO)

175 Cited Publications

Cat. No.: HY-P7118

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: TGFB1; Transforming Growth Factor Beta1; Prev. TGFB; Camurati-Engelmann Disease; Prev. DPD1; Latency-Associated peptide; TGFbeta; TGF-Beta-1; CED; TGF-Beta1; Transforming Growth Factor Beta-1 Proprotein; IBDIMDE; Prepro-Transforming Growth Factor Beta-1;

Species:

Human

Source:

CHO

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162

Anisomycin

162 Cited Publications

Cat. No.: HY-18982

CAS No.: 22862-76-6

Synonyms: Flagecidin; Wuningmeisu C

Category:

Infection Microorganisms Antibiotics Disease Research Antibacterial Disease Research Fields Other Antibiotics

Target:

DNA/RNA Synthesis JNK Bacterial Apoptosis Antibiotic Parasite

Anisomycin is a potent protein synthesis inhibitor which interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system . Anisomycin is a JNK activator, which increases phospho-JNK . Anisomycin is a bacterial antibiotic .

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148

Caerulein

148 Cited Publications

Cat. No.: HY-A0190

CAS No.: 17650-98-5

Synonyms: Ceruletide; Cerulein; FI-6934

Category:

Cardiovascular Disease Alkaloids Animals Disease Research Fields Endocrinology Indole Alkaloids

Target:

Cholecystokinin Receptor

Caerulein is a decapeptide and a potent cholecystokinin receptor agonist. Caerulein is a safe and effective cholecystokinetic agent with a direct spasmogenic effect on the gallbladder muscle and bile ducts .

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135

GsMTx4

135 Cited Publications

Cat. No.: HY-P1410

CAS No.: 1209500-46-8

Target:

TRP Channel Piezo Channel

Research Areas:

Cardiovascular Disease Neurological Disease Inflammation/Immunology

GsMTx4 is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology .

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135

GsMTx4 TFA

135 Cited Publications

Cat. No.: HY-P1410A

Target:

TRP Channel Piezo Channel

Research Areas:

Cardiovascular Disease Neurological Disease Inflammation/Immunology

GsMTx4 TFA is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 TFA also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 TFA is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology .

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106

Vancomycin hydrochloride

106 Cited Publications

Cat. No.: HY-17362

CAS No.: 1404-93-9

Category:

Disease Research Antibacterial Other Antibiotics Microorganisms Plant Cell Culture Antibiotics Phenols Polyphenols Disease Research Fields Cancer

Target:

Bacterial Autophagy Antibiotic

Vancomycin hydrochloride is an antibiotic for the treatment of bacterial infections. It acts by inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin also alters the permeability of the cell membrane and selectively inhibits ribonucleic acid synthesis.

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106

Vancomycin

106 Cited Publications

Cat. No.: HY-B0671

CAS No.: 1404-90-6

Category:

Disease Research Antibacterial Endogenous metabolite Other Antibiotics Infection Human Gut Microbiota Metabolites Microorganisms Plant Cell Culture Antibiotics Disease Research Fields Cancer

Target:

Bacterial Autophagy Antibiotic

Vancomycin is an antibiotic for the treatment of bacterial infections.

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105

Insulin (human)

105 Cited Publications

Cat. No.: HY-P0035

CAS No.: 11061-68-0

Target:

Insulin Receptor

Research Areas:

Metabolic Disease Endocrinology

Insulin (human) is a polypeptide hormone that regulates the level of glucose. Insulin (human) can be used for the diabetes mellitus .

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105

Insulin solution (human)

105 Cited Publications

Cat. No.: HY-P0035A

CAS No.: 11061-68-0

Target:

Insulin Receptor

Research Areas:

Metabolic Disease

Insulin solution (human) is a polypeptide hormone that regulates the level of glucose. Insulin solution (human) can be used for the diabetes mellitus .

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102

Colivelin

102 Cited Publications

Cat. No.: HY-P1061

CAS No.: 867021-83-8

Target:

STAT Amyloid-β

Research Areas:

Neurological Disease

Colivelin is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3 in vitro . Colivelin exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease . Colivelin has the potential for the treatment of alzheimer's disease and ischemic brain injury

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102

Colivelin TFA

102 Cited Publications

Cat. No.: HY-P1061A

CAS No.: 2803948-60-7

Target:

STAT Amyloid-β Apoptosis

Research Areas:

Neurological Disease

Colivelin TFA is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3 in vitro . Colivelin TFA exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease . Colivelin TFA has the potential for the treatment of alzheimer's disease and ischemic brain injury .

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