Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
218 Results for "
macrocyclic
" in MedChemExpress (MCE) Product Catalog:
Products (218)
218 Results for "macrocyclic" in MCE Product Catalog:
115
115 Publications Verification
Synonyms: FK506; Fujimycin; FR900506
115
115 Publications Verification
Synonyms: FK506 monohydrate; Fujimycin monohydrate; FR900506 monohydrate
51
Category:
Alkaloids Leguminosae/Fabaceae Extract Plant Pyrrole Alkaloids Disease Research Fields Crotalaria pallida Ait. Extract Cancer
Target:
10
Category:
Infection Antibiotics Microorganism Disease Research Anticancer Disease Research Fields Other Antibiotics
Target:
9
9 Cited Publications
Synonyms: Antibiotic C 15003P3; Maytansinol isobutyrate
7
6
6 Cited Publications
Synonyms: Immunomycin; FR-900520; FK520
Category:
Neurological Disease Macrolide Antibiotics Antifungal Anti-inflammation/Immunoregulatory Antibiotics Microorganism Disease Research Disease Research Fields Inflammation/Immunology
Target:
5
Category:
Infection Antibiotics Mammalian Cell Culture Microorganism Disease Research Antibacterial Disease Research Fields Other Antibiotics
Target:
3
3 Cited Publications
Art. -Nr.: HY-N6686
CAS. Nr.: 21411-53-0
Synonyms: Pristinamycin IIA; Ostreogrycin A
Category:
Infection Macrolide Antibiotics Antibiotics Microorganism Disease Research Antibacterial Disease Research Fields
Target:
3
1
1 Cited Publications
Target:
Forschungsgebiete:
Umirolimus, a macrocyclic triene lactone Rapamycin derivative, is powerful immunosuppressant and anti-inflammatory agent. Umirolimus has highly lipophilicity and can be used agent-eluting stent (DES) applications .
1
Target:
Forschungsgebiete:
Cyclam is a macrocyclic polyamine that can serve as a high-affinity chelator for Cu2+ and a CXCR4-targeting motif. Cyclam is the CXCR4-binding unit of the CXCR4 antagonist Plerixafor (AMD3100) (HY-10046). Cyclam-based macrocyclic compounds possess anti-HIV activity and can mobilize stem cells from the bone marrow. Cyclam can be used in research on ovarian cancer with high CXCR4 expression, as well as in the development of Cu 2+ sensors and lanthanide luminescent bioprobes .
1
1 Cited Publications
Art. -Nr.: HY-P5963
CAS. Nr.: 2983116-47-6
Target:
Forschungsgebiete:
1
1 Cited Publications
Art. -Nr.: HY-P1206
CAS. Nr.: 174688-78-9
Target:
Forschungsgebiete:
CH 275 is a peptidic somatostatin analog that acts as an agonist of SST1 (IC50 = 30.9 nM, Ki = 52 nM). The IC50 values of CH 275 for sst3, sst4, sst2, and sst5 are 345 nM, >1 μM, >10 μM, and >10 μM, respectively. CH 275 binds to SSTR1 via the IAmp9-Asp137 ion pair interaction and the hydrophobic interaction between the isopropyl group of IAmp9 and Leu107, and reduces the extracellular acidification rate. CH 275 induces weak sst1 internalization, exerts immunosuppressive effects on macrophages, and decreases macrophage viability, MCP-1 expression/secretion, and IL-8 secretion, but does not alter proMMP-9 secretion or IL-8 mRNA levels. CH 275 reduces hippocampal β-amyloid levels and alleviates plaque pathology without inducing hippocampal microglial activation. CH 275 is used in research on Alzheimer's disease, Parkinson's disease, and depression .
1
1 Cited Publications
Synonyms: Muconomycin A
Forschungsgebiete:
Verrucarin A (Muconomycin A), a Type D macrocyclic mycotoxin derived from the pathogen fungus Myrothecium verrucaria, is an inhibitor of protein synthesis. Verrucarin A inhibits growth of leukemia cell lines and activates caspases and apoptosis and inflammatory signaling in macrophages. Verrucarin A effectively increased the phosphorylation of p38 MAPK and diminished the phosphorylation of ERK/Akt. Verrucarin A caused cell cycle deregulation through the induction of p21 and p53 .
1
1 Cited Publications
Synonyms: FK506-13C,d2; Fujimycin-13C,d2; FR900506-13C,d2
Art. -Nr.: HY-P3502
CAS. Nr.: 1841136-73-9
Synonyms: RA101495; RA3193
Target:
Forschungsgebiete:
Art. -Nr.: HY-N7765
CAS. Nr.: 104987-36-2
Art. -Nr.: HY-W007656
CAS. Nr.: 294-90-6
Category:
Natural Products Plant Stephania japonica (Thunb.) Miers Extract Other Diseases Menispermaceae Extract Disease Research Fields
Target:
Art. -Nr.: HY-P10033
CAS. Nr.: 245080-24-4
Target:
Forschungsgebiete:
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
