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oleanane-type triterpenoid

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By Targets:	Akt (2) Apoptosis (2) Bacterial (1) Bcl-2 Family (1) Biochemical Assay Reagents (2) CDK (2) Drug Derivative (4) ERK (2) Fungal (1) HSV (1) JNK (2) mTOR (2) NO Synthase (1) PI3K (2) Reference Standards (1) VEGFR (2) Wee1 (2) Wnt (2) β-catenin (2)
By Research Areas:	Cancer (7) Cardiovascular Disease (3) Infection (2) Inflammation/Immunology (4) Metabolic Disease (4) Neurological Disease (2)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0819

Raddeanin A 1 Publications Verification	Apoptosis PI3K Akt ERK mTOR Wnt β-catenin Wee1 JNK VEGFR CDK	Neurological Disease Inflammation/Immunology Cancer
Raddeanin A is an oleanane-type triterpenoid saponin with oral activity. Raddeanin A inhibits SRC, mTOR, JNK, VEGFR2, NLRP3 inflammasome, Wnt/β-catenin, Wee1, PI3K/AKT signaling pathway, MAPK/ERK signaling pathway, AR-FL, AR-Vs, and downregulates the expression of p-PI3K and p-AKT. Raddeanin A inhibits osteoclast formation, bone resorption, osteolysis, cancer cell invasion, migration, proliferation, angiogenesis and epithelial-mesenchymal transition, while induces apoptosis, cell cycle arrest, ROS production, immunogenic cell death and dendritic cell maturation. Raddeanin A improves blood-retinal barrier function, alleviates inflammation, regulates the tumor microenvironment, and enhances the activity of anti-PD-1 antibody. Raddeanin A is applicable to the research of breast cancer-associated osteolysis, human osteosarcoma, colorectal cancer, glioblastoma, Alzheimer's disease, cholangiocarcinoma, melanoma, non-small cell lung cancer, castration-resistant prostate cancer and multiple myeloma .

HY-N7026

Celosin I 1 Publications Verification	Others	Metabolic Disease
Celosin I, an oleanane-type triterpenoid saponin isolated from the seeds of Celosia argentea L, could be used as chemical markers for the quality control of C. argentea seeds. Celosin I exhibits significant hepatoprotective effect on carbon tetrachloride-induced and N,N-dimethylformamide-induced hepatotoxicity in mice .

HY-N8156

Soyasapogenol C	HSV	Infection
Soyasapogenol C is an oleanane-type triterpenoid. Soyasapogenol C exhibits anti-HSV-1 activity, with an IC₅₀ of 18.9 μM .

HY-N8609

Uralsaponin C	Others	Others
Uralsaponin C is an analogue of oleanane-type triterpenoid saponin. Uralsaponin C can be isolated from the roots of Glycyrrhiza uralensis Fisch .

HY-N11068

Huzhangoside C	Others	Others
Huzhangoside C is a oleanane-type triterpenoid saponin that can be isolated from the roots of Clematis argentilucida .

HY-N13847

Uralsaponin B	Bacterial	Inflammation/Immunology
Uralsaponin B is classified as an oleanane-type triterpenoid saponin. Uralsaponin B exhibits potential anti-inflammatory and anti-infective activities.

HY-N3523

3-O-Beta-D-Glucopyranosylplatycodigenin	Others	Cancer
3-O-Beta-D-Glucopyranosylplatycodigenin is an oleanane-type triterpenoid isolated from roots of Platycodon grandiflorum. 3-O-Beta-D-Glucopyranosylplatycodigenin exhibits anti-proliferative activities against HSC-T6 cell line with an IC₅₀ of 13.36 μM .

HY-N13115A

Protoescigenin 21-tiglate (E)-21-Angeloyl-protoaescigenin	Others	Cancer
Protoescigenin 21-tiglate (compound 10) is a glycosidic oleanane-type triterpenoid (BAT) that can be isolated from the acid hydrolysis product (AHP) of the crude extract of Aesculus chinensis seeds. Aesculus-derived triterpenoids (BAT) generally exhibit good antitumor, anti-inflammatory, and anti-Alzheimer's activities. However, the antitumor activity of Protoescigenin 21-tiglate is relatively weak, with IC50 values of >80 μM and 80 μM against MCF-7 and HeLa cells, respectively .

HY-N13115

21-Angeloyl-protoaescigenin (Z)-Protoescigenin 21-tiglate	Others	Cancer
21-Angeloyl-protoaescigenin (compound 11) is a glycosidic oleanane-type triterpenoid (BAT) that can be isolated from the acid hydrolysis product (AHP) of the crude extract of Aesculus chinensis seeds. Aesculus-derived triterpenoids (BAT) generally exhibit good antitumor, anti-inflammatory, and anti-Alzheimer's activities. Protoescigenin 21-tiglate has antitumor activity, with IC50 values of 38.2 μM and 33 μM against MCF-7 and HeLa cells, respectively .

HY-N19813

Flaccidoside VI	NO Synthase	Others
Flaccidoside VI is an inhibitor of nitric oxide production belonging to oleanane-type triterpenoid saponins. Flaccidoside VI can be isolated from the rhizomes of Anemone flaccida. Flaccidoside VI exhibits significant inhibitory activity against lipopolysaccharide-induced nitric oxide production .

HY-N19794

Derrisaponin A	Drug Derivative	Cardiovascular Disease Metabolic Disease
Derrisaponin A is an oleanane-type triterpenoid saponin and sweetener found in the stems of Derris eriocarpa, with sweetness intensity approximately 80 times that of Sucrose (HY-B1779) at 1% concentration. Derrisaponin A shows no acute toxic activity. Derrisaponin A can be used for research on hypertension, hyperglycemia, and obesity .

HY-N19793

Derrisaponin B	Drug Derivative	Cardiovascular Disease Metabolic Disease
Derrisaponin B is an oleanane-type triterpenoid saponin and sweetener found in the stems of Derris eriocarpa How, with sweetness intensity approximately 2 times that of Sucrose (HY-B1779) at 1% concentration. Derrisaponin B exhibits sweet taste activity. Derrisaponin B can be used for research on hypertension, hyperglycemia, and obesity .

HY-N19857

Millettiasaponin A	Biochemical Assay Reagents	Cardiovascular Disease Metabolic Disease
Millettiasaponin A is an oleanane-type triterpenoid saponin found in the stems of Derris eriocarpa and roots of Millettia speciosa. Millettiasaponin A is 150 times sweeter than Sucrose (HY-B1779) at 1% concentration. Millettiasaponin A can be used in research on hypertension and obesity. .

HY-N0819R

Raddeanin A (Standard)	Reference Standards Apoptosis PI3K Akt ERK mTOR Wnt β-catenin Wee1 JNK VEGFR CDK	Neurological Disease Inflammation/Immunology Cancer
Raddeanin A (Standard) is the analytical standard of Raddeanin A (HY-N0819). This product is intended for research and analytical applications. Raddeanin A is an oleanane-type triterpenoid saponin with oral activity. Raddeanin A inhibits SRC, mTOR, JNK, VEGFR2, NLRP3 inflammasome, Wnt/β-catenin, Wee1, PI3K/AKT signaling pathway, MAPK/ERK signaling pathway, AR-FL, AR-Vs, and downregulates the expression of p-PI3K and p-AKT. Raddeanin A inhibits osteoclast formation, bone resorption, osteolysis, cancer cell invasion, migration, proliferation, angiogenesis and epithelial-mesenchymal transition, while induces apoptosis, cell cycle arrest, ROS production, immunogenic cell death and dendritic cell maturation. Raddeanin A improves blood-retinal barrier function, alleviates inflammation, regulates the tumor microenvironment, and enhances the activity of anti-PD-1 antibody. Raddeanin A is applicable to the research of breast cancer-associated osteolysis, human osteosarcoma, colorectal cancer, glioblastoma, Alzheimer's disease, cholangiocarcinoma, melanoma, non-small cell lung cancer, castration-resistant prostate cancer and multiple myeloma.

HY-N17961

Kalopanaxsaponin I Septemloside I	Others	Inflammation/Immunology
Kalopanaxsaponin I (Septemloside I) is an oleanane-type triterpenoid that exists in the fruits of Stauntonia brachyanthera. Kalopanaxsaponin I inhibits LPS (HY-D1056)-induced nitric oxide production in macrophages, with a IC₅₀ of 80.25 μM .

HY-N19757

(3β,16α-Hydroxy)-3-O-(2'acetamido-2'-deoxy-β-D-glucopyranosyl) echinocystic acid	Fungal	Infection
3-O-(2-Acetamido-2-deoxy-β-D-glucopyranosyl) echinocystic acid is an oleanane-type triterpenoid saponin. 3-O-(2-Acetamido-2-deoxy-β-D-glucopyranosyl) echinocystic acid acts as a dermatophyte growth inhibitor with a MIC range of 6.25-25 μg/mL. 3-O-(2-Acetamido-2-deoxy-β-D-glucopyranosyl) echinocystic acid can be used in the research of dermatophyte infections, bacterial infections and yeast infections .

HY-N17752

Phaseoloideside C	Others	Cancer
Phaseoloideside C is an oleanane-type triterpenoid saponin. Phaseoloideside C can be isolated from the seeds of Entada phaseoloides. Phaseoloideside C exhibits no cytotoxicity against hepatocellular carcinoma cells, esophageal carcinoma cells, cervical carcinoma cells, and colon carcinoma cells .

HY-E71272

β-Amyrin 28-monooxygenase	Biochemical Assay Reagents	Others
β-Amyrin 28-monooxygenase (EC 1.14.13.201), found in plants, is involved in the biosynthesis of oleanane-type triterpenoids, such as ginsenoside Ro. The enzyme from Medicago trunculata (CYP716A12) can also convert α-amyrin and lupeol to ursolic acid and betulinic acid, respectively.

HY-N9826

Icterogenin	Bcl-2 Family	Cancer
Icterogenin is a selective inhibitor targeting the Bcl-XL/Bak BH3 domain peptide interaction and exhibits anti-leukemic activity. Icterogenin regulates protein interactions and affects tumor cell survival. Icterogenin is an oleanane-type triterpenoid compound that can be isolated from Lantana camara and is useful in the field of anti-tumor drug development .

HY-N1853

3β-Acetoxy-12α-hydroxyoleanan-13β,28-olide	Drug Derivative	Others
3β-Acetoxy-12α-hydroxyoleanan-13β,28-olide is a natural triterpene.

HY-N17570

23α-Hydroxy-olean-12-en-3-one	Drug Derivative	Others
23α-Hydroxy-olean-12-en-3-one (Compound 15) is a pentacyclic triterpenoid, which is a natural derivative of the oleanane skeleton .

Raddeanin A 1 Publications Verification	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Plants Disease Research Fields Source Classification Cancer	Apoptosis PI3K Akt ERK mTOR Wnt β-catenin Wee1 JNK VEGFR CDK
Raddeanin A is an oleanane-type triterpenoid saponin with oral activity. Raddeanin A inhibits SRC, mTOR, JNK, VEGFR2, NLRP3 inflammasome, Wnt/β-catenin, Wee1, PI3K/AKT signaling pathway, MAPK/ERK signaling pathway, AR-FL, AR-Vs, and downregulates the expression of p-PI3K and p-AKT. Raddeanin A inhibits osteoclast formation, bone resorption, osteolysis, cancer cell invasion, migration, proliferation, angiogenesis and epithelial-mesenchymal transition, while induces apoptosis, cell cycle arrest, ROS production, immunogenic cell death and dendritic cell maturation. Raddeanin A improves blood-retinal barrier function, alleviates inflammation, regulates the tumor microenvironment, and enhances the activity of anti-PD-1 antibody. Raddeanin A is applicable to the research of breast cancer-associated osteolysis, human osteosarcoma, colorectal cancer, glioblastoma, Alzheimer's disease, cholangiocarcinoma, melanoma, non-small cell lung cancer, castration-resistant prostate cancer and multiple myeloma .

Celosin I 1 Publications Verification	Triterpenes Structural Classification Celosia argentea Linn. Classification of Application Fields Terpenoids Metabolic Disease Amaranthaceae Plants Disease Research Fields Source Classification	Others
Celosin I, an oleanane-type triterpenoid saponin isolated from the seeds of Celosia argentea L, could be used as chemical markers for the quality control of C. argentea seeds. Celosin I exhibits significant hepatoprotective effect on carbon tetrachloride-induced and N,N-dimethylformamide-induced hepatotoxicity in mice .

Soyasapogenol C	Infection Triterpenes Trifolium repens Linn. Classification of Application Fields Leguminosae Terpenoids Plants Disease Research Fields Source Classification	HSV
Soyasapogenol C is an oleanane-type triterpenoid. Soyasapogenol C exhibits anti-HSV-1 activity, with an IC₅₀ of 18.9 μM .

Uralsaponin C	Triterpenes Leguminosae Ketones, Aldehydes, Acids Terpenoids Plants Glycyrrhiza uralensis Fisch. Source Classification	Others
Uralsaponin C is an analogue of oleanane-type triterpenoid saponin. Uralsaponin C can be isolated from the roots of Glycyrrhiza uralensis Fisch .

Huzhangoside C	Clematis uncinata Champ. Ranunculaceae Lignans Phenylpropanoids Plants Source Classification	Others
Huzhangoside C is a oleanane-type triterpenoid saponin that can be isolated from the roots of Clematis argentilucida .

Uralsaponin B	Leguminosae Ketones, Aldehydes, Acids Plants Glycyrrhiza uralensis Fisch. Source Classification	Bacterial
Uralsaponin B is classified as an oleanane-type triterpenoid saponin. Uralsaponin B exhibits potential anti-inflammatory and anti-infective activities.

3-O-Beta-D-Glucopyranosylplatycodigenin	Triterpenes Classification of Application Fields Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Plants Disease Research Fields Cancer Source Classification	Others
3-O-Beta-D-Glucopyranosylplatycodigenin is an oleanane-type triterpenoid isolated from roots of Platycodon grandiflorum. 3-O-Beta-D-Glucopyranosylplatycodigenin exhibits anti-proliferative activities against HSC-T6 cell line with an IC₅₀ of 13.36 μM .

Protoescigenin 21-tiglate (E)-21-Angeloyl-protoaescigenin	Aesculus chinensis Bunge Triterpenes Terpenoids Hippocastanaceae Plants Source Classification	Others
Protoescigenin 21-tiglate (compound 10) is a glycosidic oleanane-type triterpenoid (BAT) that can be isolated from the acid hydrolysis product (AHP) of the crude extract of Aesculus chinensis seeds. Aesculus-derived triterpenoids (BAT) generally exhibit good antitumor, anti-inflammatory, and anti-Alzheimer's activities. However, the antitumor activity of Protoescigenin 21-tiglate is relatively weak, with IC50 values of >80 μM and 80 μM against MCF-7 and HeLa cells, respectively .

21-Angeloyl-protoaescigenin (Z)-Protoescigenin 21-tiglate	Aesculus chinensis Bunge Triterpenes Terpenoids Hippocastanaceae Plants Source Classification	Others
21-Angeloyl-protoaescigenin (compound 11) is a glycosidic oleanane-type triterpenoid (BAT) that can be isolated from the acid hydrolysis product (AHP) of the crude extract of Aesculus chinensis seeds. Aesculus-derived triterpenoids (BAT) generally exhibit good antitumor, anti-inflammatory, and anti-Alzheimer's activities. Protoescigenin 21-tiglate has antitumor activity, with IC50 values of 38.2 μM and 33 μM against MCF-7 and HeLa cells, respectively .

Flaccidoside VI	Triterpenes Structural Classification Anemone flaccida Fr. Schmidt Terpenoids Ranunculaceae Plants Source Classification	NO Synthase
Flaccidoside VI is an inhibitor of nitric oxide production belonging to oleanane-type triterpenoid saponins. Flaccidoside VI can be isolated from the rhizomes of Anemone flaccida. Flaccidoside VI exhibits significant inhibitory activity against lipopolysaccharide-induced nitric oxide production .

Derrisaponin A	Triterpenes Structural Classification Leguminosae Terpenoids Brachypterum eriocarpum (F. C. How) Adema & Sirich. Plants Source Classification	Drug Derivative
Derrisaponin A is an oleanane-type triterpenoid saponin and sweetener found in the stems of Derris eriocarpa, with sweetness intensity approximately 80 times that of Sucrose (HY-B1779) at 1% concentration. Derrisaponin A shows no acute toxic activity. Derrisaponin A can be used for research on hypertension, hyperglycemia, and obesity .

Derrisaponin B	Triterpenes Structural Classification Leguminosae Terpenoids Brachypterum eriocarpum (F. C. How) Adema & Sirich. Plants Source Classification	Drug Derivative
Derrisaponin B is an oleanane-type triterpenoid saponin and sweetener found in the stems of Derris eriocarpa How, with sweetness intensity approximately 2 times that of Sucrose (HY-B1779) at 1% concentration. Derrisaponin B exhibits sweet taste activity. Derrisaponin B can be used for research on hypertension, hyperglycemia, and obesity .

Millettiasaponin A	Triterpenes Structural Classification Leguminosae Terpenoids Brachypterum eriocarpum (F. C. How) Adema & Sirich. Plants Source Classification	Biochemical Assay Reagents
Millettiasaponin A is an oleanane-type triterpenoid saponin found in the stems of Derris eriocarpa and roots of Millettia speciosa. Millettiasaponin A is 150 times sweeter than Sucrose (HY-B1779) at 1% concentration. Millettiasaponin A can be used in research on hypertension and obesity. .

Raddeanin A (Standard)	Triterpenes Structural Classification other families Terpenoids Plants Source Classification	Reference Standards Apoptosis PI3K Akt ERK mTOR Wnt β-catenin Wee1 JNK VEGFR CDK
Raddeanin A (Standard) is the analytical standard of Raddeanin A (HY-N0819). This product is intended for research and analytical applications. Raddeanin A is an oleanane-type triterpenoid saponin with oral activity. Raddeanin A inhibits SRC, mTOR, JNK, VEGFR2, NLRP3 inflammasome, Wnt/β-catenin, Wee1, PI3K/AKT signaling pathway, MAPK/ERK signaling pathway, AR-FL, AR-Vs, and downregulates the expression of p-PI3K and p-AKT. Raddeanin A inhibits osteoclast formation, bone resorption, osteolysis, cancer cell invasion, migration, proliferation, angiogenesis and epithelial-mesenchymal transition, while induces apoptosis, cell cycle arrest, ROS production, immunogenic cell death and dendritic cell maturation. Raddeanin A improves blood-retinal barrier function, alleviates inflammation, regulates the tumor microenvironment, and enhances the activity of anti-PD-1 antibody. Raddeanin A is applicable to the research of breast cancer-associated osteolysis, human osteosarcoma, colorectal cancer, glioblastoma, Alzheimer's disease, cholangiocarcinoma, melanoma, non-small cell lung cancer, castration-resistant prostate cancer and multiple myeloma.

Kalopanaxsaponin I Septemloside I	Structural Classification Stauntonia cavalerieana Gagnep. Terpenoids Lardizabalaceae Plants Pentacyclic Triterpenoids Source Classification	Others
Kalopanaxsaponin I (Septemloside I) is an oleanane-type triterpenoid that exists in the fruits of Stauntonia brachyanthera. Kalopanaxsaponin I inhibits LPS (HY-D1056)-induced nitric oxide production in macrophages, with a IC₅₀ of 80.25 μM .

(3β,16α-Hydroxy)-3-O-(2'acetamido-2'-deoxy-β-D-glucopyranosyl) echinocystic acid	Triterpenes Structural Classification Leguminosae Terpenoids Archidendron lucidum (Benth.) I. C. Nielsen Plants Source Classification	Fungal
3-O-(2-Acetamido-2-deoxy-β-D-glucopyranosyl) echinocystic acid is an oleanane-type triterpenoid saponin. 3-O-(2-Acetamido-2-deoxy-β-D-glucopyranosyl) echinocystic acid acts as a dermatophyte growth inhibitor with a MIC range of 6.25-25 μg/mL. 3-O-(2-Acetamido-2-deoxy-β-D-glucopyranosyl) echinocystic acid can be used in the research of dermatophyte infections, bacterial infections and yeast infections .

Phaseoloideside C	Structural Classification Entada phaseoloides (L.) Merr. Leguminosae Terpenoids Plants Pentacyclic Triterpenoids Source Classification	Others
Phaseoloideside C is an oleanane-type triterpenoid saponin. Phaseoloideside C can be isolated from the seeds of Entada phaseoloides. Phaseoloideside C exhibits no cytotoxicity against hepatocellular carcinoma cells, esophageal carcinoma cells, cervical carcinoma cells, and colon carcinoma cells .

Icterogenin	Structural Classification Terpenoids Verbenaceae Plants Pentacyclic Triterpenoids Lantana camaraLinn. Source Classification	Bcl-2 Family
Icterogenin is a selective inhibitor targeting the Bcl-XL/Bak BH3 domain peptide interaction and exhibits anti-leukemic activity. Icterogenin regulates protein interactions and affects tumor cell survival. Icterogenin is an oleanane-type triterpenoid compound that can be isolated from Lantana camara and is useful in the field of anti-tumor drug development .

3β-Acetoxy-12α-hydroxyoleanan-13β,28-olide	Triterpenes Structural Classification Terpenoids Pieris japonica (Thunb.) D. Don ex G. Don Ericaceae Plants Source Classification	Drug Derivative
3β-Acetoxy-12α-hydroxyoleanan-13β,28-olide is a natural triterpene.

23α-Hydroxy-olean-12-en-3-one	Triterpenes Structural Classification Caprifoliaceae Terpenoids Dipsacus asper Wall. Plants Source Classification	Drug Derivative
23α-Hydroxy-olean-12-en-3-one (Compound 15) is a pentacyclic triterpenoid, which is a natural derivative of the oleanane skeleton .

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oleanane-type triterpenoid

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