![Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside](https://file.medchemexpress.com/product_pic/hy-n5084.gif "Click to View Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside Product Detail")
Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
85 Results for "
thresholds
" in MedChemExpress (MCE) Product Catalog:
Products (85)
85 Results for "thresholds" in MCE Product Catalog:
25
3
3 Cited Publications
Cat. No.: HY-N0745
CAS No.: 94596-28-8
Category:
Umbelliferae/Apiaceae Extract Natural Products Plant Ligusticum chuanxiong Hort. Extract Disease Research Fields Inflammation/Immunology
Target:
3
3 Cited Publications
Cat. No.: HY-P10234A
Target:
Research Areas:
2
2 Cited Publications
Target:
Research Areas:
S107 is an orally available, blood brain barrier-permeable compound, which stabilizes RyR2 channels by enhancing the binding of calstabin 2 to the mutant Ryr2-R2474S channel. S107 inhibits Ca 2+ leakage from the sarcoplasmic reticulum (SR) and prevents cardiac arrhythmias and raises the seizure threshold .
1
Category:
Alkaloids Leguminosae/Fabaceae Extract Plant Neurological Disease Other Alkaloids Disease Research Fields Crotalaria pallida Ait. Extract Endocrinology
Target:
1
1 Cited Publications
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
PSB36 is a highly selective A1 adenosine receptor antagonist, with a Ki of 0.12 nM and a Kd of 0.7 nM. Systemic administration of PSB36 reduces formalin- and Carrageenan (HY-125474)-induced edema in mice and decreases pain-related behaviors, with no local paw activity. PSB36 prolongs the APD90 of rat and human atria, produces a frequency-dependent prolongation of rat atrial ERP, increases the diastolic threshold of rat atria, and shortens the duration of atrial fibrillation episodes. PSB36 can be used in research related to inflammatory pain, inflammatory hyperalgesia, edema and atrial fibrillation .
1
Target:
Research Areas:
Mianserin (Mianserine) is an orally active H1 receptor antagonist. Mianserin can activate κ-opioid receptor and octopamine receptor. Mianserin increases ERK1/2 and CREB phosphorylation, and antagonizes full κ-opioid agonist and Dynorphin A (HY-P1333)-induced MAPK phosphorylation. Mianserin modulates social and exploratory behaviour, raises electroconvulsive thresholds. Mianserin can be used for the research of neurological disease, such as depression and epilepsy .
1
1 Cited Publications
Cat. No.: HY-N5084
CAS No.: 205370-59-8
Cat. No.: HY-W105835
CAS No.: 3344-18-1
Synonyms: Trimagnesium dicitrate
Target:
Research Areas:
Magnesium citrate (Trimagnesium dicitrate) is an orally active magnesium-containing compound that can cross the blood-brain barrier (BBB). Magnesium citrate can be used as an intestinal cleanser and is studied for its application in laxatives. Magnesium citrate can also increase the pain threshold and is studied for pain-relief purposes .
Cat. No.: HY-B1657A
CAS No.: 92134-98-0
Target:
Research Areas:
Fosphenytoin disodium is a prodrug of Phenytoin (HY-B0448). Fosphenytoin disodium can be converted to Phenytoin in vivo, which blocks voltage-gated sodium channels in a voltage- and use-dependent manner, prolonging inactivation and slowing recovery. Fosphenytoin disodium enhances GABA responses and, at higher concentrations, mildly modulates calcium channels and increases sodium-potassium ATPase activity. Fosphenytoin disodium raises the afterdischarge threshold, reduces the severity and duration of seizures, alleviates pain-like behavior, and protects hippocampal pyramidal neurons after ischemia without altering GFAP immunoreactivity. Fosphenytoin disodium can be used in research on acute herpes zoster pain, epilepsy, and cerebral ischemia .
Cat. No.: HY-P1626
CAS No.: 928007-64-1
Target:
Research Areas:
Cat. No.: HY-W011235
CAS No.: 57226-68-3
Target:
Drug Metabolite Potassium Channel Calcium Channel Apoptosis Serotonin Transporter Cytochrome P450
Research Areas:
Norfluoxetine hydrochloride is the active metabolite of the antidepressant Fluoxetine (HY-B0102); it is also a TREK-2 K2P potassium channel inhibitor with an IC50 of 2.7 μM. Norfluoxetine hydrochloride also inhibits placental aromatase (CYP19A1) (Ki = 2.1 µM), reduces placental estrogen secretion, and reduces serotonin transporter (SERT) activity. Norfluoxetine hydrochloride has neuroimmune activity, induces apoptosis in primary microglia (apoptosis), and inhibits the release of pro-inflammatory factors. Norfluoxetine hydrochloride inhibits neuronal high-threshold voltage-gated Ca 2+ currents with an EC50 of 20.4 μM. Norfluoxetine hydrochloride can be used in research related to depression, ischemic stroke, and epilepsy .
Synonyms: 2-Amino-6-methylheptane; 1,5-Dimethylhexylamine; 6-Methyl-2-heptylamine
Category:
Natural Products Plant Other Diseases Aconitum carmichaeli Debx. Extract Disease Research Fields Ranunculaceae Extract
Target:
Cat. No.: HY-W067716
CAS No.: 59981-63-4
Synonyms: (S)-Spinacine
Target:
Cat. No.: HY-N15936
CAS No.: 2936622-21-6
Research Areas:
a15:0-i15:0 PE is an atypical TLR2 agonist, and its immune signaling strictly depends on the TLR2-TLR1 heterodimer. a15:0-i15:0 PE induces dendritic cells to produce TNFα and IL-6, but does not induce the production of IL-10 or IL-12p70. At low doses, a15:0-i15:0 PE resets the activation threshold of immune cells to suppress or regulate immune responses against specific agonists .
Cat. No.: HY-18961
CAS No.: 622864-54-4
Target:
Research Areas:
PD 407824 is a checkpoint kinase Chk1 and WEE1 inhibitor with IC50s of 47 and 97 nM, respectively. PD 407824 is a chemical BMP sensitizer and increases the sensitivity of cells to sub-threshold amounts of BMP4 .
Cat. No.: HY-135556
CAS No.: 83891-03-6
Category:
Cat. No.: HY-119747
CAS No.: 137941-92-5
Target:
Research Areas:
WAY-123223 is an orally active potassium channel (Potassium Channel) blocker. WAY-123223 prolongs the transmembrane action potential duration and cardiac refractory period of canine Purkinje fibers. In canine models, WAY-123223 increases the ventricular fibrillation threshold, restores sinus rhythm from ventricular fibrillation, and exerts antiarrhythmic effects. WAY-123223 can be used in research related to cardiovascular diseases such as arrhythmias .
Cat. No.: HY-101546A
CAS No.: 32728-75-9
Synonyms: (+)-Cavidine
Category:
Alkaloids Plant Corydalis yanhusuo W. T. Wang Extract Isoquinoline Alkaloids Papaveraceae Extract
Target:
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
