Cat. No.: HY-N6725

Sterigmatocystine

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Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor. Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals.

For research use only. We do not sell to patients.

Purity: 99.74%
CAS No.: 10048-13-2
Formula: C₁₈H₁₂O₆
Molecular Weight:324.28

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Sterigmatocystine Chemical Structure

CAS No.: 10048-13-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor^[1]^[2]. Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals^[3].

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

All DNA/RNA Synthesis Isoforms :

All Antibiotic Isoforms :

All Endogenous Metabolite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	3.63 μM Compound: 7	Cytotoxicity against human MCF7 cells after 72 hrs by Alamar Blue assay Cytotoxicity against human MCF7 cells after 72 hrs by Alamar Blue assay	[PMID: 24251417]
MDA-MB-231	IC₅₀	2.75 μM Compound: 7	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by Alamar Blue assay Cytotoxicity against human MDA-MB-231 cells after 72 hrs by Alamar Blue assay	[PMID: 24251417]
NCI-H460	IC₅₀	3.41 μM Compound: 7	Cytotoxicity against human NCI-H460 cells after 72 hrs by Alamar Blue assay Cytotoxicity against human NCI-H460 cells after 72 hrs by Alamar Blue assay	[PMID: 24251417]
PC-3M	IC₅₀	3.23 μM Compound: 7	Cytotoxicity against human PC3M cells after 72 hrs by Alamar Blue assay Cytotoxicity against human PC3M cells after 72 hrs by Alamar Blue assay	[PMID: 24251417]
SF-268	IC₅₀	2.96 μM Compound: 7	Cytotoxicity against human SF268 cells after 72 hrs by Alamar Blue assay Cytotoxicity against human SF268 cells after 72 hrs by Alamar Blue assay	[PMID: 24251417]

In Vitro

Sterigmatocystine-induced DNA damage activates the ATM/53-dependent signaling pathway, which contributes to the induction of G2 arrest in GES-1 cells^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Sterigmatocystine (ip; 3 mg/kg once daily for 14 days) inhibits p21^WAF1/CIP1^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 10048-13-2
Appearance Solid
Molecular Weight 324.28
Formula C₁₈H₁₂O₆
Color Off-white to light yellow
SMILES

O=C1C2=C(OC3=C1C(O)=CC=C3)C4=C(O[C@]5([H])[C@@]4([H])C=CO5)C=C2OC
Structure Classification
- Phenols
- Monophenols
- Phenols
- Xanthones
Initial Source
- Microorganisms
Aspergillus versicolor
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (77.09 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.0838 mL

15.4188 mL

30.8375 mL

5 mM

0.6168 mL

3.0838 mL

6.1675 mL

10 mM

0.3084 mL

1.5419 mL

3.0838 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
SDS (644 KB)
- English - EN (644 KB)
- Français - FR (644 KB)
- Deutsch - DE (644 KB)
- Norwegian - NO (644 KB)
- Español - ES (644 KB)
- Swedish - SV (644 KB)
- Italian - IT (644 KB)
- Korean - KR (644 KB)
- Portuguese - PT (644 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kusunoki M, et al. Long-term administration of the fungus toxin, sterigmatocystin, induces intestinal metaplasia and increases the proliferative activity of PCNA, p53, and MDM2 in the gastric mucosa of aged Mongolian gerbils. Environ Health Prev Med. 2011 Jul;16(4):224-31. [Content Brief]

[2]. Schroeder HW, et al. Production of sterigmatocystin by some species of the genus Aspergillus and its toxicity to chicken embryos. Appl Microbiol. 1975 Oct;30(4):589-91. [Content Brief]

[3]. Tong YF, et al. Cyclin-Dependent Kinase Inhibitor p21WAF1/CIP1 Facilitates the Development of CardiacHypertroph. Cell Physiol Biochem. 2017;42(4):1645-1656. [Content Brief]

[4]. Zhang D, et al. Sterigmatocystin-induced DNA damage triggers G2 arrest via an ATM/p53-related pathway in human gastric epithelium GES-1 cells in vitro. PLoS One. 2013 May 21;8(5):e65044. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.0838 mL	15.4188 mL	30.8375 mL	77.0939 mL
	5 mM	0.6168 mL	3.0838 mL	6.1675 mL	15.4188 mL
	10 mM	0.3084 mL	1.5419 mL	3.0838 mL	7.7094 mL
	15 mM	0.2056 mL	1.0279 mL	2.0558 mL	5.1396 mL
	20 mM	0.1542 mL	0.7709 mL	1.5419 mL	3.8547 mL
	25 mM	0.1234 mL	0.6168 mL	1.2335 mL	3.0838 mL
	30 mM	0.1028 mL	0.5140 mL	1.0279 mL	2.5698 mL
	40 mM	0.0771 mL	0.3855 mL	0.7709 mL	1.9273 mL
	50 mM	0.0617 mL	0.3084 mL	0.6168 mL	1.5419 mL
	60 mM	0.0514 mL	0.2570 mL	0.5140 mL	1.2849 mL

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Sterigmatocystine

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All DNA/RNA Synthesis Isoforms

All Antibiotic Isoforms

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Sterigmatocystine Related Classifications

HY-N6725 Related Classifications