1. Cell Cycle/DNA Damage
    Apoptosis
  2. DNA/RNA Synthesis
    Apoptosis
  3. Sterigmatocystine

Sterigmatocystine 

Cat. No.: HY-N6725
Handling Instructions

Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor. Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals.

For research use only. We do not sell to patients.

Sterigmatocystine Chemical Structure

Sterigmatocystine Chemical Structure

CAS No. : 10048-13-2

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Description

Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor[1][2]. Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals[3].

In Vitro

Sterigmatocystine-induced DNA damage activates the ATM/53-dependent signaling pathway, which contributes to the induction of G2 arrest in GES-1 cells[4].

In Vivo

Sterigmatocystine (ip; 3 mg/kg once daily for 14 days) inhibits p21WAF1/CIP1[3].

Molecular Weight

324.28

Formula

C₁₈H₁₂O₆

CAS No.

10048-13-2

SMILES

O=C1C2=C(OC3=C1C(O)=CC=C3)C4=C(O[[email protected]]5([H])[[email protected]@]4([H])C=CO5)C=C2OC

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Sterigmatocystine
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