2. Cell Cycle/DNA Damage Anti-infection Apoptosis Metabolic Enzyme/Protease
  3. DNA/RNA Synthesis Bacterial Apoptosis Antibiotic Endogenous Metabolite
  4. Sterigmatocystine

Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor. Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals.

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Sterigmatocystine Chemical Structure

Sterigmatocystine Chemical Structure

CAS No. : 10048-13-2

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1 mg USD 254 In-stock
5 mg USD 350 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Sterigmatocystine:

Sterigmatocystine Related Antibodies

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  • Biological Activity

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Description

Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor[1][2]. Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals[3].

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

In Vitro

Sterigmatocystine-induced DNA damage activates the ATM/53-dependent signaling pathway, which contributes to the induction of G2 arrest in GES-1 cells[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sterigmatocystine Related Antibodies
In Vivo

Sterigmatocystine (ip; 3 mg/kg once daily for 14 days) inhibits p21WAF1/CIP1[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

324.28

Formula

C18H12O6
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C2=C(OC3=C1C(O)=CC=C3)C4=C(O[C@]5([H])[C@@]4([H])C=CO5)C=C2OC
Structure Classification
Initial Source

Aspergillus versicolor
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (77.09 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0838 mL 15.4188 mL 30.8375 mL
5 mM 0.6168 mL 3.0838 mL 6.1675 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.74%

COA (260 KB) HNMR (102 KB) RP-HPLC (97 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0838 mL 15.4188 mL 30.8375 mL 77.0939 mL
5 mM 0.6168 mL 3.0838 mL 6.1675 mL 15.4188 mL
10 mM 0.3084 mL 1.5419 mL 3.0838 mL 7.7094 mL
15 mM 0.2056 mL 1.0279 mL 2.0558 mL 5.1396 mL
20 mM 0.1542 mL 0.7709 mL 1.5419 mL 3.8547 mL
25 mM 0.1234 mL 0.6168 mL 1.2335 mL 3.0838 mL
30 mM 0.1028 mL 0.5140 mL 1.0279 mL 2.5698 mL
40 mM 0.0771 mL 0.3855 mL 0.7709 mL 1.9273 mL
50 mM 0.0617 mL 0.3084 mL 0.6168 mL 1.5419 mL
60 mM 0.0514 mL 0.2570 mL 0.5140 mL 1.2849 mL
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Sterigmatocystine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sterigmatocystine10048-13-2DNA/RNA SynthesisBacterialApoptosisAntibioticEndogenous MetaboliteInhibitorinhibitorinhibit

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