EM20-25
EM20-25 is an inhibitor for Bcl-2, which interferes with the interaction between BCL-2 and BAX, activates caspase-9 and thus induces the apoptosis. EM20-25 affects the mitochondrial function, causes the open of permeability transition pore (PTP). EM20-25 enhances the sensitivity of cells to Staurosporine (HY-15141), and enhances the killing effect of BCL-2-expressing leukemia cells to Chlorambucil (HY-13593) and Fludarabine (HY-B0069).
For research use only. We do not sell to patients.
- CAS No.: 141266-44-6
- Formula: C15H9ClN4O6
- Molecular Weight:376.71
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Biological Activity
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Caspase 9 |
Chemical Information
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CAS No. 141266-44-6
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Molecular Weight 376.71
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Formula C15H9ClN4O6
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SMILES
O=C1NC(C(C2C3=CC(Cl)=CC=C3OC(NC(N4)=O)=C2C4=O)C(N1)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EM20-25 Related Classifications
HY-101999 Related Classifications
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