1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. Umbellulone

Umbellulone 

Cat. No.: HY-135013
Handling Instructions

Umbellulone is an active constituent of the leaves of Umbellularia californica. Umbellulone stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism.

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Umbellulone Chemical Structure

Umbellulone Chemical Structure

CAS No. : 546-78-1

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Description

Umbellulone is an active constituent of the leaves of Umbellularia californica. Umbellulone stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism[1].

IC50 & Target

TRPA1 channel[1]

In Vitro

Umbellulone, from µM to sub-mM concentrations, selectively stimulates transient receptor potential ankyrin 1-expressing HEK293 cells[1].

In Vivo

Umbellulone (50–250 nM/5ul) causes an acute nocioceptive response in a dose-dependent manner in Trpa1+/+ mice[1].
Umbellulone (150 µg/kg; intravenous or intranasal) do not affect systemic blood pressure[1].
Umbellulone (30-150 μg/kg; i.v.) increases meningeal blood flow in a dose-dependent manner[1].

Animal Model: Sprague-Dawley rats (male, 250 g)[1]
Dosage: 30 μg/kg, 75 μg/kg, 150 μg/kg
Administration: Intravenously
Result: Increased meningeal blood flow in a dose-dependent manner.
Molecular Weight

150.22

Formula

C₁₀H₁₄O

CAS No.

546-78-1

SMILES

O=C1[[email protected]@]2(C(C)C)C[[email protected]@]2([H])C(C)=C1

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

UmbelluloneTRP ChannelTransient receptor potential channelsTRPA1channeltrigeminovascularsystemInhibitorinhibitorinhibit

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