Cat. No.: HY-123581

Quinocetone

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

Quinocetone is an orally active animal feed additive used to increase the meat production of livestock and poultry. Quinocetone exhibits antibacterial activity against a variety of pathogenic microorganisms. Quinocetone exhibits tissue-specific (liver, lymphocyte) toxicity. Quinocetone induces autophagy in cells through the ATF6/DAPK1 pathway. Quinocetone activates the NF-κB and iNOS pathways, leading to cell apoptosis, hepatocyte vacuolar degeneration and fibrosis. Quinocetone can inhibit Nrf2/HO-1 and induce the generation of reactive oxygen species (ROS), leading to oxidative stress and DNA damage.

For research use only. We do not sell to patients.

Purity: 98.25%
CAS No.: 81810-66-4
Formula: C₁₈H₁₄N₂O₃
Molecular Weight:306.32

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Quinocetone Chemical Structure

CAS No.: 81810-66-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[2]^[3]^[4]

NF-κB

iNOS

DAPK1

HO-1

All Antibiotic Isoforms :

All NF-κB Isoforms :

All NO Synthase Isoforms :

All Heme Oxygenase (HO) Isoforms :

HO-1
HO-2

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	IC₅₀	5.92 μM Compound: 3a	Growth inhibition of human CEM cells after 3 days Growth inhibition of human CEM cells after 3 days	[PMID: 19427790]
HL-60	CC₅₀	4.1 μM Compound: 3a	Cytotoxicity against human HL60 cells after 48 hrs Cytotoxicity against human HL60 cells after 48 hrs	[PMID: 19427790]
HSC-2	CC₅₀	8.4 μM Compound: 3a	Cytotoxicity against human HSC2 cells after 48 hrs Cytotoxicity against human HSC2 cells after 48 hrs	[PMID: 19427790]
HSC-3	CC₅₀	9.7 μM Compound: 3a	Cytotoxicity against human HSC3 cells after 48 hrs Cytotoxicity against human HSC3 cells after 48 hrs	[PMID: 19427790]
HSC-4	CC₅₀	9.6 μM Compound: 3a	Cytotoxicity against human HSC4 cells after 48 hrs Cytotoxicity against human HSC4 cells after 48 hrs	[PMID: 19427790]
MOLT-4	IC₅₀	6.76 μM Compound: 3a	Growth inhibition of human Molt4/C8 cells after 3 days Growth inhibition of human Molt4/C8 cells after 3 days	[PMID: 19427790]

In Vitro

Quinocetone is active against Microsporum canis, Mycoplasma gallisepticum and Mycoplasma hyopneumoniae with MICs of 8, 8 and 16 μg/mL but shows no significant inhibitory effect on various animal viruses including bursal disease virus, porcine reproductive and respiratory syndrome virus, porcine parvovirus and classical swine fever virus^[1].
Quinocetone (0-10 μg/mL, 0-24 h) triggers ER stress-induced autophagy via ATF6/DAPK1-modulated mAtg9a trafficking in HepG2 cells^[2].
Quinocetone (0-20 μg/mL, 6-24 h) inhibits in human peripheral lymphocytes growth, triggers ROS increase and induced DNA damage^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2].

Cell Line:

HepG2 cells
Concentration:

0, 1.25, 2.5, 5, 7.5, 10 μg/mL
Incubation Time:

0, 1.5, 3, 6, 9, 12, 24 h
Result:

Significantly increased the LC3-II/LC3-I ratio.
Dose-dependently upregulated BiP and CHOP expression and increased ATF6 cleavage.
Significantly upregulated DAPK1 expression and MRLC phosphorylation.

RT-PCR^[2].

Cell Line:

HepG2 cells
Concentration:

0, 1.25, 2.5, 5, 7.5, 10 μg/mL
Incubation Time:

0, 1.5, 3, 6, 9, 12, 24 h
Result:

Increased BiP, HerpUD and sec24D transcription.
Increased DAPK1 mRNA.

In Vivo

Quinocetone (50-2400 mg/kg, i.g., once daily for 13 weeks)-induced Nrf2/HO-1 pathway suppression aggravates hepatocyte damage of Sprague-Dawley rats at high dose^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Hepatocyte damage assay established in adult male SD rats^[4]
Dosage:

50, 800 and 2400 mg/kg
Administration:

Intragastrical administration (p.o.), once daily for 13 weeks
Result:

Kept all rats survived and no obviously significant changes were observed in mortality, illness and clinical signs.
Induced liver damage and liver was likely to be the target organ at high dose.
Aggravated ROS accumulation in liver and aggravated DNA damage at high dose.
Aggravated inflammation and apoptosis of hepatocyte at high dose.
Inhibited aggravated inflammation and apoptosis of hepatocyte at high dose.

Chemical Information

CAS No. 81810-66-4
Appearance Solid
Molecular Weight 306.32
Formula C₁₈H₁₄N₂O₃
Color White to yellow
SMILES

O=C(C1=C(C)[N+]([O-])=C2C=CC=CC2=[N+]1[O-])/C=C/C3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

Chin Herb Med

Integrated network pharmacology, transcriptomics and experimental validation to explore mechanisms of Wenyang Jiedu Granule on IAV-induced pneumonia. [Abstract]

2026 Feb 11;18(2):241-261. PMID: 41971577

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (326.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.2646 mL

16.3228 mL

32.6456 mL

5 mM

0.6529 mL

3.2646 mL

6.5291 mL

10 mM

0.3265 mL

1.6323 mL

3.2646 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (418 KB)
- English - EN (418 KB)
- Français - FR (418 KB)
- Deutsch - DE (418 KB)
- Norwegian - NO (418 KB)
- Español - ES (418 KB)
- Swedish - SV (418 KB)
- Italian - IT (418 KB)
- Korean - KR (418 KB)
- Portuguese - PT (418 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhao Y, et al. In vitro antimicrobial activities of animal-used quinoxaline 1,4-di-N-oxides against mycobacteria, mycoplasma and fungi. BMC Vet Res. 2016 Sep 6;12(1):186. [Content Brief]

[2]. Zhou Y, et al. Quinocetone triggered ER stress-induced autophagy via ATF6/DAPK1-modulated mAtg9a trafficking. Cell Biol Toxicol. 2016 Apr;32(2):141-52. [Content Brief]

[3]. Yang W, et al. Quinocetone triggers oxidative stress and induces cytotoxicity and genotoxicity in human peripheral lymphocytes of both genders. J Sci Food Agric. 2013 Apr;93(6):1317-25. [Content Brief]

[4]. Yu M, et al. Quinocetone-induced Nrf2/HO-1 pathway suppression aggravates hepatocyte damage of Sprague-Dawley rats. Food Chem Toxicol. 2014 Jul;69:210-9. doi: 10.1016/j.fct.2014.04.026. Epub 2014 Apr 30. PMID: 24795230. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.2646 mL	16.3228 mL	32.6456 mL	81.6140 mL
	5 mM	0.6529 mL	3.2646 mL	6.5291 mL	16.3228 mL
	10 mM	0.3265 mL	1.6323 mL	3.2646 mL	8.1614 mL
	15 mM	0.2176 mL	1.0882 mL	2.1764 mL	5.4409 mL
	20 mM	0.1632 mL	0.8161 mL	1.6323 mL	4.0807 mL
	25 mM	0.1306 mL	0.6529 mL	1.3058 mL	3.2646 mL
	30 mM	0.1088 mL	0.5441 mL	1.0882 mL	2.7205 mL
	40 mM	0.0816 mL	0.4081 mL	0.8161 mL	2.0403 mL
	50 mM	0.0653 mL	0.3265 mL	0.6529 mL	1.6323 mL
	60 mM	0.0544 mL	0.2720 mL	0.5441 mL	1.3602 mL
	80 mM	0.0408 mL	0.2040 mL	0.4081 mL	1.0202 mL
	100 mM	0.0326 mL	0.1632 mL	0.3265 mL	0.8161 mL

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Quinocetone

Anti-Infection Compound Library

Apoptosis Compound Library

Cell Cycle/DNA Damage Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

Stem Cell Signaling Compound Library

Autophagy Compound Library

Anti-Aging Compound Library

Antioxidant Compound Library

Oxygen Sensing Compound Library

Antibacterial Compound Library

Ferroptosis Compound Library

Endoplasmic Reticulum Stress Compound Library

Pyroptosis Compound Library

Orally Active Compound Library

Antibiotics Library

Anti-Breast Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Anti-Parkinson's Disease Compound Library

Neurodegenerative Disease-related Compound Library

Angiogenesis-Related Compound Library

Transcription Factor-Targeted Library

Anti-Colorectal Cancer Compound Library

Human Metabolite Library

Anti-Pulmonary Fibrosis Compound Library

Pain-Related Compound Library

Metabolic Enzyme Compound Library

Membrane Protein-targeted Compound Library

Highly Selective Inhibitors Library

Highly Selective Activators Library

Cell Death Library

Anti-Ovarian Cancer Compound Library

Multi-Target Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) Quinocetone

All Antibiotic Isoforms

All NF-κB Isoforms

All NO Synthase Isoforms

All Heme Oxygenase (HO) Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Quinocetone Related Classifications

HY-123581 Related Classifications