Deubiquitinase
DUBs
Deubiquitinases (DUBs) are a family of proteases whose function is to cleave ubiquitin (Ub) or ubiquitin-like proteins from proproteins or ubiquitin(s) conjugated with target substrate. DUBs are divided into two main classes according to their enzymatic cleavage mechanism: cysteine proteases and zinc metalloproteases. These include ubiquitin-specific proteases (USPs), ubiquitin C-terminal hydrolases (UCHs), ovarian tumor proteases (OTUs), Machado-Joseph disease proteases (MJDs), Jab1/Mov34/Mpr1 (JAMM) metalloproteases, and MIU-containing novel DUB family, (MINDY) proteases.
Ubiquitination is an important post-translational modification that plays a key role in many vital cellular events. In this process, ubiquitin is attached to a substrate protein by the concerted action of an enzyme cascade involving E1, E2 and E3 enzymes and it is removed by DUBs. DUBs are therefore important regulators of the Ub system and regulate a plethora of cellular processes, including protein turnover, protein sorting, and trafficking. Altered DUB activity is associated with a multitude of pathologies including cancer. DUBs represent novel candidates for target-directed drug development.
Deubiquitinase Isoform Specific Products
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Deubiquitinase
(142)
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USP1
(13)
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USP2
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USP4
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USP7
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USP8
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USP10
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USP21
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USP30
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UCHL1
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USP11
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USP15
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USP28
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USP25
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Deubiquitinase Inhibitors
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Deubiquitinase Agonist
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Deubiquitinase Activator
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Deubiquitinase Chemical
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Deubiquitinase Degraders
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Deubiquitinase Ligands
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Deubiquitinase Proteins
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Deubiquitinase Related Products (212)
Related Products (212)
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Recombinant Proteins (48)
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Antibodies (16)
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Deubiquitinase Isoform Comparison
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USP1-IN-20
0 ImagesCat. No.: HY-189455CAS No.: 3094127-54-2USP1-IN-20 is an orally effective and selective USP1 inhibitor with an IC50 of 3.0 nM. USP1-IN-20 inhibits the USP1-UAF1 complex, leading to the accumulation of Ub-PCNA, which in turn induces DNA damage and G2/M phase arrest, while simultaneously promoting the degradation of the oncogenic protein c-MYC. USP1-IN-20 can be used for research on breast cancer and diffuse large B-cell lymphoma.
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USP1-IN-15
0 ImagesCat. No.: HY-180216USP1-IN-15 is an orally active and selective USP1 inhibitor with an IC50 of 12.3 nM. USP1-IN-15 has a high specificity for USP1 with negligible inhibition against all off-target DUBs. USP1-IN-15 suppresses colony formation, induces S-phase arrest, and stabilizes ubiquitinated PCNA. USP1-IN-15 also shows synergistic antiproliferative activity. USP1-IN-15 achieves significant tumor growth inhibition in vivo. USP1-IN-15 can be used for BRCA-mutated breast cancer.
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USP30-IN-2
0 ImagesCat. No.: HY-182553CAS No.: 2414580-72-4USP30-IN-2, a fused pyrroline, is an USP30 inhibitor with an IC50 <0.1 μM. USP30-IN-2 is expected to promote mitophagy and restore mitochondrial health. USP30-IN-2 can be used for research on Parkinson's disease.
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ChlaDUB1-IN-2
0 ImagesCat. No.: HY-172220ChlaDUB1-IN-2 (Compound 27a) is the inhibitor for Chlamydia trachomatis deubiquitinase ChlaDUB1 with an IC50 of 0.97 μM. ChlaDUB1-IN-2 inhibits the inclusion body formation of C. trachomatis with an IIC50 of 25.6 μg/mL.
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USP1-IN-14
0 ImagesCat. No.: HY-179292CAS No.: 3084277-96-0
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SE486-11
0 ImagesCat. No.: HY-187705CAS No.: 305333-99-7SE486-11 is an orally active USP5 inhibitor. SE486-11 increases free polyubiquitin chains and promotes the ubiquitination and degradation of MYCN. The combination of SE486-11 with SAHA (HY-10221) synergistically induces Apoptosis. SE486-11 can be used in research related to MYCN-driven neuroblastoma.
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MT16-001
0 ImagesCat. No.: HY-182636CAS No.: 1895049-73-6MT16-001 is a cell-permeable UCHL1 inhibitor with an IC50 value of 580 nM. MT16-001 also exhibits considerable inhibitory activity against USP30, and shows selectivity for other UCH family deubiquitinases (DUBs) as well as the broader proteome. MT16-001 binds covalently to the cysteine residue at the active site of UCHL1, and forms covalent interactions with ALDH2, ALDH9A1 and GATD3A in intact cells. Meanwhile, as a cytotoxic agent, it displays a steep dose-response curve in human embryonic kidney cells. MT16-001 can be used for research on various cancers, liver fibrosis and pulmonary fibrosis.
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USP30-IN-1
0 ImagesUSP30-IN-1 is a potent and selective USP30 inhibitor, with IC50 values of 94 nM and 4 nM in vivo and in vitro, respectively, and Ki values of 0.33 μM (Krippendorf method) and 0.38 μM (traditional method), respectively. USP30-IN-1 covalently binds to the catalytic cysteine (Cys77) of USP30, blocks ubiquitin substrate binding to inhibit deubiquitination, and ultimately induces mitophagy. USP30-IN-1 can be used for the research of idiopathic Parkinson's disease and mitophagy-related diseases.
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N-Ethylmaleimide (Standard)
0 ImagesBayogenin (Standard) is the analytical standard of Bayogenin. This product is intended for research and analytical applications. Bayogenin is an alfalfa saponin, shows moderate potency of glycogen phosphorylase inhibition.
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USP7-IN-16
0 ImagesCat. No.: HY-159964CAS No.: 2166587-77-3USP7-IN-16 (Compound 61) is a selective USP7 inhibitor with IC50 values of 5.5 nM in the FLINT assay and 2.1 nM in MM.1S cells. USP7-IN-16 exhibits antitumor activity in mice and is a promising candidate for research in the field of oncology.
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USP10-IN-1
0 ImagesCat. No.: HY-125015CAS No.: 904448-58-4USP10-IN-1 is a USP10 inhibitor.
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P6620
0 ImagesCat. No.: HY-183078CAS No.: 2009272-81-3P6620 is an orally active USP7 inhibitor. P6620 specifically binds to USP7 and disrupts its interaction with LRRC41. P6620 exhibits anticancer activity against hepatocellular carcinoma. P6620 enhances the antitumor effect of Lenvatinib (HY-10981) in xenograft mouse models. P6620 can be used for the research of hepatocellular carcinoma.
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MS5128
0 ImagesCat. No.: HY-183725CAS No.: 3060520-82-0MS5128 is an OTUB1-based deubiquitinase-targeting chimera (DUBTAC) targeting CFTR. MS5128 recruits OTUB1 to CFTR to induce deubiquitination and stabilization of CFTR. MS5128 can be used for the research of cystic fibrosis. (Blue: CFTR Ligand (HY-183724); Pink: OTUB1 Ligand (HY-13262); Black: Linker)
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USP1-IN-19
0 ImagesCat. No.: HY-187468CAS No.: 3068739-67-0USP1-IN-19 is a USP1 inhibitor with an IC50 of 0-50 nM in the USP1-UAF1 deubiquitination assay. USP1-IN-19 exhibits dose-dependent antitumor effects against non-small cell lung cancer and breast cancer. USP1-IN-19 can be used for cancer research.
