PPAR
Peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating gene expression. There are three main isoforms: PPARα, PPARβ/δ, and PPARγ, each with distinct tissue distribution and biological roles. PPARα is primarily expressed in liver, heart, and muscle, where it regulates fatty acid oxidation and lipid metabolism[1]. PPARβ/δ is widely expressed and involved in energy homeostasis, glucose metabolism, and inflammation modulation[1]. PPARγ is highly expressed in adipose tissue and plays a central role in adipogenesis, insulin sensitivity, and lipid storage[2].
References:
- [1]. Man versus microbe. Nat Med. 2004 Dec;10(12 Suppl):S69. doi: 10.1038/nm1149. PMID: 15577933; PMCID: PMC7096048. et al. Nat Med. 2004 Dec;10(12 Suppl):S69. [Content Brief]
- [2]. Kiros M, et al. Trends in HIV-1 pretreatment drug resistance and HIV-1 variant dynamics among antiretroviral therapy-naive Ethiopians from 2003 to 2018: a pooled sequence analysis. Virol J. 2023 Oct 25;20(1):243. [Content Brief]
- [3]. Brent J, et al. Fomepizole for the treatment of ethylene glycol poisoning. Methylpyrazole for Toxic Alcohols Study Group. N Engl J Med. 1999 Mar 18;340(11):832-8. [Content Brief]
- [4]. Liu Y, et al. Neuron-mediated generation of regulatory T cells from encephalitogenic T cells suppresses EAE. Nat Med. 2006 May;12(5):518-25. [Content Brief]
- [5]. Paranjape AN, et al. Introduction of SV40ER and hTERT into mammospheres generates breast cancer cells with stem cell properties. Oncogene. 2012 Apr 12;31(15):1896-909. [Content Brief]
- [6]. Iancu-Rubin C, et al. Whirling Platelets Away for Transfusion. Cell. 2018 Jul 26;174(3):503-504. [Content Brief]
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PPAR Related Products (400)
Related Products (400)
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dual FXR/PPARδ agonist-2
0 ImagesCat. No.: HY-175516dual FXR/PPARδ agonist-2 is a FXR/PPARδ dual agonist through hybridation of FXR agonist GW-4064 and PPARδ agonist GW-0742.dual FXR/PPARδ agonist-2 displays potent dual-target activities with a FXR agonistic EC50 of 12.28 nM and 69 % PPARδ activation at 100 nM. dual FXR/PPARδ agonist-2 shows anti-fibrotic effects in pulmonary fibrosis mouse model.
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SR 1824
0 ImagesCat. No.: HY-120542CAS No.: 1338259-06-5SR 1824 is a non-agonist PPARγ ligand that blocks Cdk5-mediated phosphorylation. SR 1824 has anti-diabetic effects.
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Rosiglitazone-d4-1
0 ImagesCat. No.: HY-17386S2CAS No.: 1132641-20-3Synonyms: BRL 49653-d4-1
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D-arabinose-13C-2
0 ImagesCat. No.: HY-N0059S2D-arabinose-13C-2 is the 13C-labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC50 is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-Arabinose (HY-N7082).
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C333H
0 ImagesCat. No.: HY-126969CAS No.: 870095-15-1C333H is a selective PPARγ modulator with insulin-sensitizing and hypoglycemic activities. C333H exhibits similar insulin-sensitizing effects to thiazolidinediones (TZDs) in diabetic mouse models without significantly increasing body weight or adipose tissue weight. C333H increases circulating high molecular weight adiponectin isoform levels in diabetic db/db mice, reduces serine phosphorylation of PPARγ 273 in brown adipose tissue, and selectively modulates the expression of specific PPARγ target genes in adipose tissue. Express. C333H exhibits weak recruitment of co-activators and weak dissociation of co-repressors in vitro. These properties suggest that C333H may be a potential inhibitor of type 2 diabetes.
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Raspberry ketone-d5
0 ImagesCat. No.: HY-W740498CAS No.: 182219-43-8Synonyms: Frambione-d5; 4-(4-Hydroxyphenyl)-2-butanone-d5Raspberry ketone-d5 (Frambione-d5; 4-(4-Hydroxyphenyl)-2-butanone-d5) is the deuterium labeled Raspberry ketone (HY-N1426). Raspberry ketone is a major aromatic compound of red raspberry, widely used as a fragrance in cosmetics and as a flavoring agent in foodstuff; also shows PPAR-α agonistic activity.
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MHY908
0 ImagesCat. No.: HY-117761CAS No.: 1393371-39-5MHY908 is a potent dual agonist of PPARα and PPARγ. MHY908 also inhibits melanogenesis through inhibition of mushroom tyrosinase activity.
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Perfluoroenanthic acid-13C4
0 ImagesCat. No.: HY-21197SCAS No.: 2328024-55-9Synonyms: Perfluoroheptanoic acid-13C4; Tridecafluoroheptanoic acid-13C4; PFHpA-13C4Perfluoroenanthic acid-13C4 (Perfluoroheptanoic acid-13C4) is the 13C-labeled Perfluoroenanthic acid (HY-21197). Perfluoroenanthic acid (Perfluoroheptanoic acid) is a kind of perfluoroalkyl carboxylic acid organic pollutant. Perfluoroenanthic acid has environmental persistence and bioaccumulation, and exposure can occur via oral, dermal and other routes. Perfluoroenanthic acid exhibits reproductive toxicity, neurotoxicity, hepatotoxicity, immunotoxicity and endocrine-disrupting effects. Perfluoroenanthic acid exerts definite adverse effects on development, spermatogenesis, neuronal activity and liver tissue.
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CRX000227
0 ImagesCat. No.: HY-153759CAS No.: 686769-92-6CRX000227 is a PPAR modulator. CRX000227 can be used for research of metabolic or cell proliferative disorders.
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D-Arabinose-d6
0 ImagesCat. No.: HY-N0059S6D-Arabinose-d6 is the deuterated-labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC50 is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-Arabinose (HY-N7082).
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Dehydroabietic acid (Standard)
0 ImagesDehydroabietic acid (Standard) is the analytical standard of Dehydroabietic acid. This product is intended for research and analytical applications. Dehydroabietic acid is a diterpene resin acid that can be isolated from Pinus and Picea. Dehydroabietic acid has anti-bacterial, anti-fungal, anti-inflammatory, and anticancer activities. Dehydroabietic acid is a dual PPAR-α/γ agonist and PPAR-γ partial agonist, which can attenuate insulin resistance (IR) and hepatic steatosis induced by HFD-consumption in mice.
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(E/Z)-ABP/PPAR modulator 1
0 ImagesCat. No.: HY-172883A(E/Z)-ABP/PPAR modulator 1 is a mixture of the E and Z isomers of ABP/PPAR modulator 1 (HY-172883). ABP/PPAR modulator 1 is an orally active FABP and PPAR multiple modulator (IC50s of 0.65 μM and 1.08 μM for FABP1 and FABP4, EC50 s of 9.19 μM, 2.20 μM and 1.58 μM for PPARα, PPARγ and PPARδ). ABP/PPAR modulator 1 has potent anti-metabolic dysfunction-associated steatohepatitis (MASH) activity. ABP/PPAR modulator 1 dose-dependently ameliorates multiple pathological characteristics of fatty liver in WD + Carbon tetrachloride-induced MASH mice model.
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Sodium propionate (Standard)
0 ImagesSodium propionate (Standard) is the analytical standard of Sodium propionate. This product is intended for research and analytical applications. Sodium propionate is an orally active short-chain fatty acid. Sodium propionate can be produced by intestinal bacteria from the metabolism of dietary fiber. Sodium propionate increases PPAR-γ, inhibits NF-κB activation, and reduces COX-2 expression and NO production. Sodium propionate also induces Apoptosis and Autophagy. Sodium propionate reduces HSV-1-induced keratitis. Sodium propionate has anticancer effects against glioblastoma. Sodium propionate exhibits neuroprotective, antioxidant, and anti-inflammatory activities. Sodium propionate can be used in the research of spinal cord injury and Alzheimer's disease.
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Soyasaponin Aa (Standard)
0 ImagesCat. No.: HY-N3027RCAS No.: 117230-33-8Soyasaponin Aa (Standard) is the analytical standard of Soyasaponin Aa (HY-N3027). Soyasaponin Aa is a soyasaponin that can be found in soy. Soyasaponin Aa suppresses PPARγ transcriptional activity, reduces PPARγ and C/EBPα expression, inhibits adipocyte differentiation and lipid accumulation, and reduces adipogenic marker gene expression. Soyasaponin Aa reduces hydrogen peroxide-induced reactive oxygen species (ROS) production and malondialdehyde levels. Soyasaponin Aa exhibits cellular antioxidant activity. Soyasaponin Aa can be used for the research of obesity.
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RB394
0 ImagesCat. No.: HY-118397CAS No.: 1830320-32-5RB394 is a potent dual sEH/PPARγ modulator isoform that promotes adipocyte browning and exhibits cardioprotective activity, and can be used to suppress metabolic syndrome.
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17-Oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-docosahexaenoic acid
0 ImagesCat. No.: HY-139408CAS No.: 1233715-28-0Synonyms: 17-Oxo-DHA; 17-Oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-DHA17-Oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-docosahexaenoic acid (17-Oxo-DHA) is a metabolite of lipoxygenase-mediated oxidation of DHA. 17-Oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-docosahexaenoic acid is a PPARγ agonist and activates a Nrf2 dependent antioxidant reaction.
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PIISVYWK
0 ImagesCat. No.: HY-P11589CAS No.: 2016043-80-2
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D-Arabinose (Standard)
0 ImagesD-Arabinose (Standard) is the analytical standard of D-Arabinose (HY-N0059). This product is intended for research and analytical applications. D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC50 is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-Arabinose (HY-N7082).
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PPARα agonist 3
0 ImagesCat. No.: HY-163862PPARα agonist 3 (Compound A229) is a PPARα agonist (EC50: 590 nM). PPARα agonist 3 inhibits TBHP or 4-HNE (HY-113466)-induced production of ROS.
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LS2265
0 ImagesCat. No.: HY-100189CAS No.: 72678-30-9LS2265 is a taurine derivative of fenofibrate and can induce proliferation of peroxisomes in liver cells of rats.
