Phosphodiesterase (PDE)
Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond. Usually, people speaking of phosphodiesterase are referring to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, as well as numerous less-well-characterized small-molecule phosphodiesterases. The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators ofsignal transduction mediated by these second messenger molecules.
Phosphodiesterase (PDE) Isoform Specific Products
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Phosphodiesterase (PDE)
(553)
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PDE1
(60)
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PDE2
(51)
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PDE3
(93)
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PDE4
(198)
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PDE5
(97)
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PDE6
(22)
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PDE7
(28)
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PDE9
(19)
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PDE10
(53)
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PDE11
(13)
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PDE12
(2)
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PDE8
(11)
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Autotaxin
(36)
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All Product Categories
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Phosphodiesterase (PDE) Inhibitors
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Phosphodiesterase (PDE) Agonists
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Phosphodiesterase (PDE) Antagonists
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Phosphodiesterase (PDE) Activators
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Phosphodiesterase (PDE) Modulators
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Phosphodiesterase (PDE) Degraders
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Phosphodiesterase (PDE) Controls
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Phosphodiesterase (PDE) Substrates
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Phosphodiesterase (PDE) Ligand
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Phosphodiesterase (PDE) Related Products (1009)
Related Products (1009)
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Antibodies (4)
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Phosphodiesterase (PDE) Isoform Comparison
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Levosimendan (Standard)
0 ImagesSynonyms: Simsndan (Standard); OR-1259 (Standard); (4R)-Simendan (Standard)Levosimendan (Standard) is the analytical standard of Levosimendan. This product is intended for research and analytical applications. Levosimendan (Simsndan; OR-1259) is a calcium sensitiser used in the management of acutely decompensated congestive heart failure.
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NPD-039
0 ImagesCat. No.: HY-167233CAS No.: 2229043-40-5NPD-039 is a selective tetrahydrophthalazinone-class TbrPDEB1 inhibitor with a Ki of 99 nM. NPD-039 occupies the hydrophobic clamp and the parasite-specific P-pocket of TbrPDEB1, and its glycinamide tail forms direct and water-mediated hydrogen bond interactions within the P-pocket. NPD-039 can be used in related research on Human African Trypanosomiasis.
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Difamilast (Standard)
0 ImagesSynonyms: OPA-15406 (Standard)Difamilast (Standard) is the analytical standard of Difamilast. This product is intended for research and analytical applications. Difamilast (OPA-15406) is a topical, selective and nonsteroidal phosphodiesterase-4 (PDE4) inhibitor with particularly efficient inhibition of subtype B (IC50=11.2 nM). Difamilast can be used for the research of mild to moderate atopic dermatitis (AD).
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CI-930
0 ImagesCat. No.: HY-183455CAS No.: 86798-59-6CI-930 is a selective, orally active phosphodiesterase 3 (PDE3) inhibitor with an IC50 value of 0.0.84 μM. CI-930 exerts positive inotropic and vasodilatory effects by inhibiting cAMP hydrolysis. CI-930 also regulates hemodynamics, inhibits the proliferation of coronary artery smooth muscle cells, and suppresses the proliferation of mouse splenocytes. CI-930 can be used in research related to heart failure, atherosclerosis, and asthma.
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RS14203
0 ImagesCat. No.: HY-69317CAS No.: 159925-31-2Synonyms: PMNPQRS14203 is an orally active type IV cyclic nucleotide phosphodiesterase (PDE IV) inhibitor which can induce emesis.
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PDE5-IN-7 (Standard)
0 ImagesPDE5-IN-7 (Standard) is the analytical standard of PDE5-IN-7 (HY-W011336). This product is intended for research and analytical applications. PDE5-IN-7 (compound 8) is a selective phosphodiesterase 5 (PDE 5) inhibitor with an IC50 value of 5 nM, while an IC50 of 300 nM for PDE 1.
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BML-288
0 ImagesCat. No.: HY-114023CAS No.: 851681-89-5BML-288 (compound Oxindole 1) is a potent PDE2 inhibitor with an IC50 value of 40 nM. BML-288 has the potential for the research of osteoarthritis pain.
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W-7 hydrochloride (Standard)
0 ImagesCat. No.: HY-100912RCAS No.: 61714-27-0W-7 (hydrochloride) (Standard) is the analytical standard of W-7 (hydrochloride) (HY-100912). This product is intended for research and analytical applications. W-7 hydrochloride is a selective calmodulin antagonist. W-7 hydrochloride inhibits the Ca2+-calmodulin-dependent phosphodiesterase and myosin light chain kinase with IC50 values of 28 μM and 51 μM, respectively. W-7 hydrochloride induces apoptosis and has antitumor and vascular relaxing activity. W-7 hydrochloride is a blocker of Kv4.3 and can be used for research of arrhythmias.
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Propoxyphenyl Aildenafil
0 ImagesCat. No.: HY-131383CAS No.: 1391053-82-9Propoxyphenyl Aildenafil is a Sildenafil analogue. Propoxyphenyl Aildenafil can be used for the research of enhancement of sexual function.
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UK-371800
0 ImagesCat. No.: HY-19446CAS No.: 247582-13-4UK-371800 is a highly selective PDE5 inhibitor (IC50 = 4.2 nM). UK-371800 has good permeability and is not affected by the efflux of P-glycoprotein.
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PDE-IN-3
0 ImagesCat. No.: HY-W171611CAS No.: 56344-53-7PDE-IN-3 (compound 23) is a phosphodiesterase (PDE) inhibitor with an IC50 of 260 μM.
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Cilostamide (Standard)
0 ImagesSynonyms: OPC3689 (Standard)Cilostamide (Standard) is the analytical standard of Cilostamide. This product is intended for research and analytical applications. Cilostamide is a selective and potent PDE3 inhibitor, with IC50s of 27 nM and 50 nM for PDE3A and PDE3B, respectively, and has antithrombotic and anti-intimal hyperplastic activity.
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Mesembrenol
0 ImagesCat. No.: HY-124482CAS No.: 25516-15-8Mesembrenol is an alkaloid inhibitor of serotonin transporters and PDE4. Mesembrenol also inhibits glutamatergic AMPA receptors and can be used in research on mild to moderate depression.
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Amrinone (Standard)
0 ImagesCat. No.: HY-B1294RCAS No.: 60719-84-8Synonyms: Inamrinone (Standard)Amrinone (Standard) is the analytical standard of Amrinone. This product is intended for research and analytical applications. Amrinone (Inamrinone) is a positive inotropic-vasodilator agent. Amrinone is a selective phosphodiesterase III inhibitor that increases cyclic adenosine monophosphate by preventing its breakdown. Amrinone is also an orally active, non-glycosidic and non-catecholamine cardiotonic agent.
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Y-590
0 ImagesCat. No.: HY-123366CAS No.: 70386-06-0Y-590 is an orally active platelet cyclic adenosine monophosphate phosphodiesterase (cAMP-PDE) inhibitor with an IC50 of 0.9 nM against rabbit cAMP-PDE. Y-590 inhibits platelet aggregation, disaggregates aggregated platelets, suppresses collagen-induced platelet release, reduces platelet retention and inhibits cAMP degradation in platelets. Y-590 enhances PGI2-mediated elevation of intracellular cAMP in platelets and exerts a synergistic effect with PGI2 on ADP-induced platelet aggregation. Y-590 can be used in studies related to thrombotic diseases and thrombosis.
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PF-05180999 (Standard)
0 ImagesCat. No.: HY-111371RCAS No.: 1394033-54-5Synonyms: PF-999 (Standard)PF-05180999 (Standard) is the analytical standard of PF-05180999 (HY-111371). This product is intended for research and analytical applications. PF-05180999 (PF-999) is a phosphodiesterase 2A (PDE2A) inhibitor, with an IC50 of 1.6 nM.
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Vardenafil hydrochloride (Standard)
0 ImagesVardenafil (hydrochloride) (Standard) is the analytical standard of Vardenafil (hydrochloride). This product is intended for research and analytical applications. Vardenafil hydrochloride is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. Vardenafil hydrochloride shows inhibitory towards PDE1, PDE6 with IC50s of 180 nM, and 11 nM, while IC50s are >1000 nM for PDE3 and PDE4. Vardenafil hydrochloride competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Vardenafil hydrochloride can be used for the research of erectile dysfunction, hepatitis, diabetes-.
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Olprinone hydrochloride solution
0 ImagesCat. No.: HY-FL14254BCAS No.: 2072803-95-1Synonyms: Loprinone hydrochloride hydrate solutionOlprinone hydrochloride solution is mainly composed of Olprinone hydrochloride hydrate (HY-14254B). Olprinone hydrochloride hydrate is a potent phosphodiesterase (PDE) 3 inhibitor, with IC50s of 150, 100, 0.35 and 14 μM for PDE1, PDE2, PDE3 and PDE4, respectively. Olprinone hydrochloride hydrate has anti-inflammatory activity, and is used for the research of heart failure due to its positive inotropic and vasodilative effects. Anti-inflammatory activity
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Lunamarine
0 ImagesLunamarine is a inhibitor of PDE5 with BBB permeability. Lunamarine can be used in the reseach of Pulmonary Arterial Hypertension (PAH) and Erectile Dysfunction (ED).
