Reactive Oxygen Species (ROS)

Related Products

Reactive oxygen species (ROS), such as superoxide anion (O₂^-), hydrogen peroxide (H₂O₂), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.

ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Reactive Oxygen Species (ROS) Related Products (2509)
Antibodies (8)

By Effects:	Inhibitors (933) Agonists (38) Controls (5) Substrates (3) Antagonists (2) Activators (438) Modulators (18) MDM2 Inhibitor (1) Inducers (551)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-W110154

2'-Hydroxy-3,4-dimethoxychalcone	Inhibitor	98.01%
2'-Hydroxy-3,4-dimethoxychalcone is a chalcone derivative and lipoxygenase inhibitor with an IC₅₀ of 67.5 μM. 2'-Hydroxy-3,4-dimethoxychalcone acts as a radical scavenger that scavenges DPPH stable free radical, superoxide anion radical, and hydroxyl radical. 2'-Hydroxy-3,4-dimethoxychalcone scavenges hydrogen peroxide and inhibits linoleic acid lipid peroxidation. 2'-Hydroxy-3,4-dimethoxychalcone can be used for research on oxidative damage and inflammatory diseases.

HY-W416228

1-O-Caffeoyl-β-D-glucopyranose	Inhibitor
1-O-Caffeoyl-β-D-glucopyranose, a phenylpropanoid compound derived from Illicium majus, exhibits significant antioxidant activity and can scavenge DPPH radicals in vitro, with an IC₅₀ value of 37.7 μM.

HY-B2046R

Simazine (Standard)	Inducer
Simazine (Standard) is the analytical standard of Simazine (HY-B2046). This product is intended for research and analytical applications. Simazine is a triazine herbicide. Simazine is widely used in agriculture, potted plant and tree production. In addition, Simazine can induce the apoptosis of immune cells in the spleen of mice and inhibit the proliferation of B cells and T cells in mice.

HY-168960

ROS inducer 8	Inducer
ROS inducer 8 (Compound 11g) is the inhibitor for glutathione (GSH), that induces the ROS accumulation in Enterococcus faecalis, thereby exhibiting antibacterial activity. ROS inducer 8 disrupts the biofilm, inhibits S. aureus and E. faecalis with MIC of 8 μg/mL and 2 μg/mL, exhibits post-antibiotic effect. ROS inducer 8 exhibits low hemolytic toxicity to sheep erythrocytes (HC₅₀ > 1280 μg/mL).

HY-B0347S

Lacidipine-d₁₀
Lacidipine-d₁₀ is the deuterium labeled Lacidipine. Lacidipine (Lacipil, Motens) is a L-type calcium channel blocker.

HY-42034R

Hydroquinine (Standard)	Inhibitor
Hydroquinine (Standard) is the analytical standard of Hydroquinine. Hydroquinine (Dihydroquinine) is an anti-bacterial agent that inhibits both Gram-positive and Gram-negative bacteria. Hydroquinine inhibits the growth of multidrug-resistant pseudomonas aeruginosa via the suppression of the arginine deiminase pathway genes. Hydroquinine inhibits Plasmodium falciparum and Plasmodium berghei. Hydroquinine displays anti-malarial and demelanizing activities. Hydroquinine effectively induces specific RND-type efflux pump systems in Pseudomonas aeruginosa, particularly the MexCD-OprJ and MexXY efflux pumps. Hydroquinine inhibits Pseudomonas aeruginosa adhesion and biofilm formation. Hydroquinine serves as a precursor for derivatives such as C9 epihydroquinine, 9-acetoxy-10,11-dihydroquinine, and 10,11-dihydroquinine monohydrochloride.

HY-P991517

BI-836858	Modulator
BI-836858 is a fully human anti-CD33 monoclonal antibody. BI-836858 reduces CD33+ cells via antibody-dependent cellular cytotoxicity (ADCC), blocks downstream signaling of S100A9/CD33, decreases the secretion of immunosuppressive cytokines and reactive oxygen species-induced genomic instability, and restores bone marrow hematopoietic function. BI-836858 is applicable to the research of myelodysplastic syndrome (MDS) and AML.

HY-124068

LQB-118	Inducer
LQB-118 is an orally active compound derived from sandalwood. LQB-118 can inhibit the migration of glioblastoma cells and induce cell death. LQB-118 can suppress the migration and invasion of prostate cancer cells by regulating the AKT/GSK3β pathway and the expression of the MMP-9/reck genes. LQB-118 can also inhibit yeast polysaccharide-induced inflammation both in vivo and in vitro. Additionally, LQB-118 selectively induces ROS-triggered and mitochondrial-dependent apoptosis in Leishmania amazonensis. LQB-118 can be used in studies related to inflammation, infections, and cancer diseases.

HY-N7063S

Nerol-d₂	Activator
Nerol-d₂ is deuterated labeled Nerol (HY-N7063). Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca2+ and ROS. Antifungal activity.

HY-119695AR

Simvastatin acid ammonium (Standard)	Inhibitor
Simvastatin acid (ammonium) (Standard) is the analytical standard of Simvastatin acid (ammonium). This product is intended for research and analytical applications. Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene.

HY-181686

Antibacterial agent 326	Activator
Antibacterial agent 326 is a bactericide that inhibits the growth of various bacterial strains. Antibacterial agent 326 inhibits biofilm formation in Escherichia coli, disrupts bacterial cell membranes, induces oxidative stress and lipid peroxidation in Escherichia coli, increases ROS levels, and reduces GSH activity. Antibacterial agent 326 can be used in studies of bacterial infections, including those caused by Escherichia coli, Staphylococcus aureus, Enterococcus faecalis, Listeria spp., Bacillus subtilis, Serratia marcescens, Salmonella enteritidis and Acinetobacter calcoaceticus.

HY-113341R

7β-Hydroxycholesterol (Standard)	Agonist
7β-Hydroxycholesterol (Standard) is the analytical standard of 7β-Hydroxycholesterol. This product is intended for research and analytical applications. 7β-Hydroxycholesterol is an oxysterol that derived by the oxidation of cholesterol. 7β-hydroxycholesterol can induce cellular oxidative stress, apoptosis, and necrosis, resulting in cytotoxicity. 7β-hydroxycholesterol has antitumor activity.

HY-W129230

Salicylic acid diethylamine	Inhibitor
Salicylic acid diethylamine (2-Hydroxybenzoic acid diethylamine) is a hormone involved in plant signaling. Salicylic acid diethylamine antagonizes the oxidative damaging effect of metal toxicity directly by acting as an antioxidant to scavenge the ROS and by activating the antioxidant systems of plants and indirectly by reducing uptake of metals from their medium of growth.

HY-121174

Alaternin	Inhibitor
Alaternin (Catharticin) is an anthraquinone compound with antioxidant and hepatoprotective activities. Alaternin has an inhibitory activity against hydroxyl radicals generated in a cell-free chemical system (FeSO₄/H₂O₂) with an IC₅₀ value of 3.05 μM. Alaternin exhibits hepatoprotective activity against Tacrine (HY-111338)-induced toxicity in human hepatic HepG2 cells with an EC₅₀ value of 4.02 μM.

HY-B0356S2

Ciprofloxacin-d₄	Inducer
Ciprofloxacin-d₄ (Bay-09867-d₄) is deuterium labeled Ciprofloxacin. Ciprofloxacin (Bay-09867) is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin has anti-proliferative activity and induces apoptosis. Ciprofloxacin is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.

HY-N0526R

2"-O-Galloylhyperin (Standard)	Inhibitor
2"-O-Galloylhyperin (Standard) is the analytical standard of 2"-O-Galloylhyperin (HY-N0526). This product is intended for research and analytical applications. 2''-O-Galloylhyperin is an active natural compound with anti‑inflammatory, antioxidant, anti‑adipogenic, antifibrotic, and cytostatic activities. 2''-O-Galloylhyperin upregulates SIRT1/Nrf2 signaling, inhibits NF-κB and MAPK (ERK1/2, p38, JNK) phosphorylation, suppresses TSHR activation, reduces ROS accumulation, and enhances SOD and GSH-Px activities. 2''-O-Galloylhyperin protects against LPS-induced tissue injury, enhances survival, and inhibits adipogenesis and fibrosis. 2"-O-Galloylhyperin can be used for the research of sepsis, acute lung injury, and thyroid eye disease.

HY-W587743

N1-Acetyl-5-methoxykynuramine hydrochloride	Inhibitor
N1-Acetyl-5-methoxykynuramine (AMK) hydrochloride is an active metabolite of the neurohormone melatonin (HY-B0075). N1-Acetyl-5-methoxykynuramine hydrochloride (200 µM) effectively scavenges singlet oxygen (ROS).1 It also inhibits the production of prostaglandin E2 (PGE2) and prostaglandin D2 (PGD2) induced by epinephrine and arachidonic acid in a concentration- and time-dependent manner, and suppresses the increase in COX-2 levels induced by LPS (HY-D1056) in RAW 264.7 macrophages at a concentration of 500 µM. In a mouse model of Parkinson's disease induced by MPTP (HY-15608), N1-Acetyl-5-methoxykynuramine hydrochloride (20 mg/kg) reduces the increase in lipid peroxidation in the cytosol and mitochondria of the substantia nigra and striatum. N1-Acetyl-5-methoxykynuramine hydrochloride can be used in research on metabolic and neurological diseases

HY-B0553R

Methazolamide (Standard)	Inhibitor
Methazolamide (Standard) is the analytical standard of Methazolamide. This product is intended for research and analytical applications. Methazolamide (L584601) is a BBB-penetrable and orally active carbonic anhydrase inhibitor, with a K_i of 14 nM for human carbonic anhydrase II. Methazolamide can reduce intraocular pressure and has a neuroprotective effect, being able to inhibit neuronal apoptosis. Methazolamide can be used in the research of ophthalmic diseases such as glaucoma and cerebrovascular diseases such as subarachnoid hemorrhage.

HY-N0484R

Liensinine (Standard)	Activator
Liensinine (Standard) is the analytical standard of Liensinine (HY-N0484). This product is intended for research and analytical applications. Liensinine is a bisbenzylisoquinoline alkaloid. By inhibiting the PI3K/AKT and JNK/p38-MAPK signaling pathways, Liensinine suppresses autophagy and apoptosis, clears Aβ, and exerts anti-inflammatory, antioxidant and neuroprotective effects. Liensinine activates AMPK and inhibits the expression of HIF-1α and VEGF, thereby suppressing angiogenesis. Liensinine exerts anti-tumor effects through ROS-mediated inhibition of the JAK2/STAT3 signaling pathway. Liensinine can be used for the research of diseases such as Alzheimer's disease, hepatocellular carcinoma, osteosarcoma, sepsis-induced organ injury and stroke.

HY-W747602

Cinidon-ethyl	Activator
Cinidon-ethyl is a herbicide. Cinidon-ethyl blocks the conversion of protoporphyrinogen IX to protoporphyrin IX, disrupts the tetrapyrrole biosynthetic process, and leads to the accumulation of protoporphyrin IX and the generation of ROS. Cinidon-ethyl induces the expression of peroxidase and defense-related genes in wheat. Cinidon-ethyl triggers light-dependent ethylene and ethane release, tissue dehydration and necrosis in sensitive broadleaf weeds. Cinidon-ethyl is applicable to research related to the control of broadleaf weeds in wheat fields.

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Reactive Oxygen Species (ROS)

Reactive Oxygen Species (ROS)

Reactive Oxygen Species (ROS) Related Products (2509)

Antibodies (8)

Reactive Oxygen Species (ROS) Related Products (2509):