Anticancer agent 298
Anticancer agent 298 is a bi-nuclear Cu(II)-hydrazone complexe. Anticancer agent 298 can bind to the CDK-2 active site (PDB ID: 3IG7) via hydrogen bonds with key amino acid residues. Anticancer agent 298 exerts cytotoxic effects against hepatocellular carcinoma cells, and has lower cytotoxicity against normal human embryonic kidney cells. Anticancer agent 298 can be used for the research of hepatocellular carcinoma.
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- Formel: C36H54Br2Cu2N6O12
- Molecular Weight:1049.75
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
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CDK2 |
Anticancer agent 298 (Compound 2) potently inhibits hepatocellular carcinoma (HepG-2) cells with an IC50 of 12.27 μM and has an IC50 of 90.16 μM against normal human embryonic kidney (HEK-2) cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 1049.75
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Formel C36H54Br2Cu2N6O12
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SMILES
CC(C1=C(O[Cu]2([OH]CC)([OH]CC)([OH]CC)Br)C=C(O[Cu]3([OH]CC)([OH]CC)([OH]CC)Br)C(C(C)=[N]3/N=C/C4=CC=CC([N+]([O-])=O)=C4)=C1)=[N]2/N=C/C5=CC([N+]([O-])=O)=CC=C5
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Anticancer agent 298 Related Classifications
HY-181116 Related Classifications
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