Filipin complex
Based on 48 publication(s) in Google Scholar
Filipin complex is a potent polyene macrolide antifungal antibiotic. Filipin complex inserts into membranes and sequester cholesterol into complexes and inhibits PRRSV entry. The Filipin complex consists of about 75.8% Filipin III (HY-N6718), 10.8% Filipin IV, 9.1% Filipin II, and 1.2% Filipin I (Ex/Em = 380/430 nm).
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- Reinheit: 97.44%
- CAS. Nr.: 11078-21-0
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Speicherung:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
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Publications Citing Use of MedChemExpress (MCE) Filipin complex
More- Signal Transduct Target Ther. 2025 May 23;10(1):171. [Abstract]
- Signal Transduct Target Ther. 2022 Jun 13;7(1):176. [Abstract]
- Mol Cancer. 2025 May 26;24(1):151. [Abstract]
- Bioact Mater. 2025 Nov 14:57:344-357. [Abstract]
- Adv Funct Mater. 2026 Jan 29.
- ACS Nano. 2025 Sep 16;19(36):32444-32459. [Abstract]
- Nat Commun. 2025 Nov 19;16(1):10123. [Abstract]
- Nat Commun. 2025 Mar 10;16(1):2368. [Abstract]
- Autophagy. 2025 May;21(5):934-956. [Abstract]
- Adv Sci (Weinh). 2026 Apr;13(19):e08588. [Abstract]
- Adv Sci (Weinh). 2025 Jun 23:e03322. [Abstract]
- Adv Sci (Weinh). 2024 Jul 12:e2406473. [Abstract]
- Adv Sci (Weinh). 2023 Jul;10(20):e2205949. [Abstract]
- Chem Eng J. 2024 Sep 1.
- Biomaterials. 2025 Oct 1:327:123760. [Abstract]
- J Nanobiotechnology. 2025 Nov 19;23(1):722. [Abstract]
- Sci Adv. 2024 Sep 20;10(38):eado0016. [Abstract]
- J Control Release. 2025 Nov 20:389:114450. [Abstract]
- J Control Release. 2024 Jun:370:140-151. [Abstract]
- J Hazard Mater. 2025 Oct 24:499:140253. [Abstract]
- J Hazard Mater. 2025 Jun 15:490:137792. [Abstract]
- Nano Today. 2025 Apr.
- Mater Today Bio. 2025 Nov 13:35:102547. [Abstract]
- Cell Mol Biol Lett. 2025 Nov 24;30(1):140. [Abstract]
- Mater Today Bio. 2025 Sep 30:35:102370. [Abstract]
- J Neuroinflammation. 2025 Oct 29;22(1):250. [Abstract]
- Int J Biol Sci. 2026 Jan 1;22(2):876-894. [Abstract]
- Acta Biomater. 2026 Mar:212:770-785. [Abstract]
- Adv Healthc Mater. 2025 May 24:e2500507. [Abstract]
- Drug Deliv. 2021 Dec;28(1):800-813. [Abstract]
- Food Res Int. 2025 Dec;221(Pt 4):117561. [Abstract]
- Environ Pollut. 2023 Jan 1;316(Pt 2):120627. [Abstract]
- Int J Nanomedicine. 2025 Dec 6:20:14613-14628. [Abstract]
- Int J Nanomedicine. 2025 Mar 27:20:3845-3860. [Abstract]
- J Anim Sci Biotechnol. 2021 May 10;12(1):63. [Abstract]
- Cell Biosci. 2025 Jul 4;15(1):95. [Abstract]
- J Agric Food Chem. 2023 Nov 1;71(43):16016-16031. [Abstract]
- J Pathol. 2023 May;260(1):17-31. [Abstract]
- Am J Physiol Cell Physiol. 2023 Jun 1;324(6):C1307-C1319. [Abstract]
- J Med Virol. 2025 Sep;97(9):e70578. [Abstract]
- Microorganisms. 2026 Mar 26;14(4):740. [Abstract]
- Am J Pathol. 2025 Nov 7:S0002-9440(25)00410-9. [Abstract]
- BMC Cancer. 2025 May 21;25(1):906. [Abstract]
- Toxicol Lett. 2025 Dec:414:111781. [Abstract]
- Biochem Biophys Res Commun. 2024 Aug 29:734:150619. [Abstract]
- bioRxiv. 2026 Apr 23.
- Res Sq. 2024 Jul 28.
- Research Square Preprint. 2024 Feb 13.
Customer Validation & Images
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Flow Cytometry
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Cell Imaging/Staining
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Cell Imaging/Staining
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Cell Imaging/Staining
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IF
Alle Antibiotic Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
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Macrolide |
Guide (The following is our recommended protocol. This protocol is only a guide and should be modified according to your specific needs).
1. Solution preparation[4]
1.1 Preparation of storage solution
Solvent: DMSO
Concentration: 50 mg/mL is recommended (e.g. weigh 50 mg Filipin complex and dissolve in 1 mL solvent).
Storage: After aliquoting, store at -20°C or -80°C away from light and avoid repeated freezing and thawing.
1.2 Preparation of working solution
Dilute to 50 μg/mL with PBS or serum-free cell culture medium (optimized according to the experiment).
Note: The working solution should be prepared and used immediately, and protected from light.
2. For neuronal cholesterol levels staining.
2.1 The staining sections are washed three times with PBS and incubated with 1.5 mg/mL glycine for 10 min at room temperature.
2.2 Then sections are stained with 0.05 mg/mL Filipin complex in PBS containing 10% FBS for 2 h and rinsed for three times with PBS.
2.3 Use an Olympus FV10i confocal microscope for image (Ex/Em = 380/430 nm).
Filipin complex (2 μg/mL; 1+48 h) inhibits PRRSV entry with respiratory syndrome virus (PRRSV) genome copies in infected cells reduced by 61% in MARC-145 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Chemical Information
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CAS. Nr. 11078-21-0
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Appearance Solid
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Color Light yellow to yellow
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SMILES
CCCCC[C@@H]([R1])[C@]1([H])[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@H](O)/C(C)=C/C=C/C=C/C=C/C=C/[C@H]([R2])[C@@H](C)OC1=O.[Filipin I :R1=H,R2=H 1% Filipin II :R1=H,R2=OH 9% Filipin III :R1=(R)-OH,R2=OH 76% Filipin IV :R1=(S)-OH,R2=OH 11%]
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Structure Classification
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Initial Source
Streptomyces filipinensis
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (48)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Porphyromonas gingivalis aggravates atherosclerotic plaque instability by promoting lipid-laden macrophage necroptosis. [Abstract]2025 May 23;10(1):171. PMID: 40404630
Filipin complex purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 May 23;10(1):171. [Abstract]
Flow cytometry analyses of the ox-LDL uptake in macrophages pretreated with Dynasore (10 mM), Filipin (5 μM; 30 min), or LY294002 (50 μM) and inoculated with/without Pg (MOI = 100). n = 4 per group.
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Signal Transduct Target Ther
Chimeric cerebral organoids reveal the essentials of neuronal and astrocytic APOE4 for Alzheimer's tau pathology. [Abstract]2022 Jun 13;7(1):176. PMID: 35691989
Filipin complex purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2022 Jun 13;7(1):176. [Abstract]
Representative images of different chCOs on D45 stained with Filipin (0.05 mg/ml in PBS containing 10% FBS for 2 h), MAP2, and human nuclei. Scale bar: 50 µm.
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Mol Cancer
GP73-dependent regulation of exosome biogenesis promotes colorectal cancer liver metastasis. [Abstract]2025 May 26;24(1):151. PMID: 40414849
Filipin complex purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2025 May 26;24(1):151. [Abstract]
Confocal micrographs of CD63 and filipin staining in cells transfected with Flag-V, Flag-GP73, or Flag-DM and quantitative mean fluorescence intensity (MFI) analysis of the Filipin, Filipin in MVBs, CD63. Green, GP73-GFP; red, CD63-mCherry; cyan, Filipin staining.
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Bioact Mater
Sustainability of functional hair follicle activity: Impact of spatially anchored multifunctional tetrahedral framework nucleic acids. [Abstract]2025 Nov 14:57:344-357. PMID: 41323202
Filipin complex purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2025 Nov 14:57:344-357. [Abstract]
Representative confocal microscopy images showing intracellular localization of fluorescently labeled TQC (red) in HFSCs after treatment with an endocytic inhibitor. Factin in green, nuclei in blue. Scale bar: 20 μm. Inhibitor concentration: Filipin complex (20 μM;pre-incubated for 1 h).
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ACS Nano
Reprogramming Macrophage Function via Cholesterol Modulation and Redox Signaling Using a Multifunctional Nanoplatform for Postoperative Breast Cancer Management. [Abstract]2025 Sep 16;19(36):32444-32459. PMID: 40905820 -
Nat Commun
2025 Nov 19;16(1):10123. PMID: 41257852
Filipin complex purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Nov 19;16(1):10123. [Abstract]
Filipin staining (50 μg/mL; 30 min in room temperature) to detect cholesterol from humans with OA (n = 6 per group) and from mice with OA (n = 4 per group).
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Nat Commun
Berberine-inspired ionizable lipid for self-structure stabilization and brain targeting delivery of nucleic acid therapeutics. [Abstract]2025 Mar 10;16(1):2368. PMID: 40064874 -
Autophagy
2025 May;21(5):934-956. PMID: 39663580 -
Adv Sci (Weinh)
Cancer Cell-Intrinsic Cholesterol Induces Lipid-Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression. [Abstract]2026 Apr;13(19):e08588. PMID: 41603134 -
Adv Sci (Weinh)
Splicing Shift of RAC1 Accelerates Tumorigenesis and Defines a Potent Therapeutic Target in Lung Cancer. [Abstract]2025 Jun 23:e03322. PMID: 40548642 -
Adv Sci (Weinh)
Otilonium Bromide Exhibits Potent Antifungal Effects by Blocking Ergosterol Plasma Membrane Localization and Triggering Cytotoxic Autophagy in Candida Albicans. [Abstract]2024 Jul 12:e2406473. PMID: 38995235 -
Adv Sci (Weinh)
PERK-Mediated Cholesterol Excretion from IDH Mutant Glioma Determines Anti-Tumoral Polarization of Microglia. [Abstract]2023 Jul;10(20):e2205949. PMID: 37166058 -
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Biomaterials
A multifunctional manganese-based nanozyme platform for synergistic hypoxia alleviation and cholesterol depletion to potentiate STING-mediated cancer immunotherapy. [Abstract]2025 Oct 1:327:123760. PMID: 41045760 -
J Nanobiotechnology
Targeting cancer stem-like cells via cholesterol modulation and ferroptosis induction using a multifunctional nanoplatform to overcome drug resistance. [Abstract]2025 Nov 19;23(1):722. PMID: 41261412 -
Sci Adv
Fusobacterium nucleatum extracellular vesicles are enriched in colorectal cancer and facilitate bacterial adhesion. [Abstract]2024 Sep 20;10(38):eado0016. PMID: 39303027 -
J Control Release
Inducing potent ferroptosis in cancer cells by manipulation of ferritinophagy with a ferritin-targeted ATTEC. [Abstract]2025 Nov 20:389:114450. PMID: 41274571 -
J Control Release
A facile and smart strategy to enhance bone regeneration with efficient vitamin D3 delivery through sterosome technology. [Abstract]2024 Jun:370:140-151. PMID: 38653347 -
J Hazard Mater
Cholesterol metabolism as a key target in triphenyl phosphate-induced testosterone biosynthesis disorder: Implications for male reproductive health. [Abstract]2025 Oct 24:499:140253. PMID: 41151519 -
J Hazard Mater
2025 Jun 15:490:137792. PMID: 40048781 -
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Mater Today Bio
SLC7A11-independent disulfidptosis induced by a two-pronged delivery strategy for bladder cancer chemotherapy and cisplatin-resistance reverse. [Abstract]2025 Nov 13:35:102547. PMID: 41322137 -
Cell Mol Biol Lett
Abnormal cholesterol-cholesteryl ester metabolism impairs mouse oocyte quality during ovarian aging. [Abstract]2025 Nov 24;30(1):140. PMID: 41286604 -
Mater Today Bio
"Top-down and Bottom-up" cholesterol-depleting biomimetic nanoparticle for enhancing sonodynamic therapy against hepatocellular carcinoma. [Abstract]2025 Sep 30:35:102370. PMID: 41104047 -
J Neuroinflammation
Diabetes exacerbates myasthenia gravis by enhancing pathological thymic output via the GPR183-7α,25-OHC axis. [Abstract]2025 Oct 29;22(1):250. PMID: 41163004 -
Int J Biol Sci
Hepatocyte SAMHD1 Deficiency Attenuates Hepatic Steatosis via Suppression of SREBP Activation in a Mouse Model of Metabolic-Associated Steatotic Liver Disease. [Abstract]2026 Jan 1;22(2):876-894. PMID: 41522335 -
Acta Biomater
A multifunctional PD-L1 modulator for metabolic reprogramming to induce pyroptosis and enhance glutamine inhibition-mediated antitumor immunotherapy. [Abstract]2026 Mar:212:770-785. PMID: 41513208 -
Adv Healthc Mater
Lipoprotein-Based Nanocatalyst Enables Targeted Treatment of APAP-Induced Liver Injury via Enhanced Macropinocytosis. [Abstract]2025 May 24:e2500507. PMID: 40411876 -
Drug Deliv
The synergistic antitumor activity of 3-(2-nitrophenyl) propionic acid-paclitaxel nanoparticles (NPPA-PTX NPs) and anti-PD-L1 antibody inducing immunogenic cell death. [Abstract]2021 Dec;28(1):800-813. PMID: 33866918 -
Food Res Int
Antifungal peptide APTs exerts its fungistatic effect against Candida albicans through interaction with lipid rafts. [Abstract]2025 Dec;221(Pt 4):117561. PMID: 41185313 -
Environ Pollut
2023 Jan 1;316(Pt 2):120627. PMID: 36370978 -
Int J Nanomedicine
2025 Dec 6:20:14613-14628. PMID: 41383278 -
Int J Nanomedicine
Dual-Mode Treatment of Hepatocellular Carcinoma Using RGD Cyclopeptide-Modified Liposomes Loaded with Ce6/DOX. [Abstract]2025 Mar 27:20:3845-3860. PMID: 40165796 -
J Anim Sci Biotechnol
Overexpression of Toll-like receptor 4 contributes to the internalization and elimination of Escherichia coli in sheep by enhancing caveolae-dependent endocytosis. [Abstract]2021 May 10;12(1):63. PMID: 33966642 -
Cell Biosci
2025 Jul 4;15(1):95. PMID: 40615893 -
J Agric Food Chem
Morusinol Extracted from Morus alba Inhibits Cell Proliferation and Induces Autophagy via FOXO3a Nuclear Accumulation-Mediated Cholesterol Biosynthesis Obstruction in Colorectal Cancer. [Abstract]2023 Nov 1;71(43):16016-16031. PMID: 37870273 -
J Pathol
The phospholipid flippase ATP9A enhances macropinocytosis to promote nutrient starvation tolerance in hepatocellular carcinoma. [Abstract]2023 May;260(1):17-31. PMID: 36715683 -
Am J Physiol Cell Physiol
Exosomes derived from oral squamous cell carcinoma tissue accelerate diabetic wound healing. [Abstract]2023 Jun 1;324(6):C1307-C1319. PMID: 37154491 -
J Med Virol
Pexophagy Triggered by Enterovirus 71 Modulates the Production of Pro-Inflammatory Cytokines Through Cholesterol Accumulation in Lysosomes. [Abstract]2025 Sep;97(9):e70578. PMID: 40856297 -
Microorganisms
25-Hydroxycholesterol Restricts Japanese Encephalitis Virus via Metabolic Suppression of the SREBP2-Mediated Signaling Axis. [Abstract]2026 Mar 26;14(4):740. PMID: 42075137 -
Am J Pathol
Nonalcoholic Steatohepatitis Exacerbates Inflammatory Bone Destruction and Macrophage NLR Family Pyrin Domain-Containing 3 Inflammasome Activation in Ligature-Induced Periodontitis. [Abstract]2025 Nov 7:S0002-9440(25)00410-9. PMID: 41205805 -
BMC Cancer
APOL4-mediated intracellular cholesterol trafficking is essential for glioblastoma cell growth. [Abstract]2025 May 21;25(1):906. PMID: 40399861 -
Toxicol Lett
1-NP hijacks endocrine-metabolic checkpoints and disrupts testicular steroidogenesis by suppressing the cAMP-PKA-CREB-HMGCR axis. [Abstract]2025 Dec:414:111781. PMID: 41319933 -
Biochem Biophys Res Commun
Polystyrene nanoplastics enhance poxvirus preference for migrasome-mediated transmission. [Abstract]2024 Aug 29:734:150619. PMID: 39232458 -
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Lösungsmittel & Löslichkeit
DMSO : ≥ 100 mg/mL
Ethanol : 10 mg/mL (ultrasonic and warming and heat to 60°C)
* "≥" means soluble, but saturation unknown.
Reinheit & Dokumentation
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Data Sheet (284 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Malcolm E. Bergy et al. Filipin complex. Biochemistry, 1968, 7, 2, 653-659.
[2]. Houdai T, et al. Membrane-permeabilizing activities of amphidinol 3, polyene-polyhydroxy antifungal from a marine dinoflagellate. Biochim Biophys Acta. 2004 Nov 17;1667(1):91-100. [Content Brief]
[3]. Huang L, et al. Role of lipid rafts in porcine reproductive and respiratory syndrome virus infection in MARC-145 cells. Biochem Biophys Res Commun. 2011 Oct 28;414(3):545-50. [Content Brief]
[4]. Huang S, et al. Chimeric cerebral organoids reveal the essentials of neuronal and astrocytic APOE4 for Alzheimer's tau pathology. Signal Transduct Target Ther. 2022 Jun 13;7(1):176. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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