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Art. -Nr.: HY-155328

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GK444

GK444 (Compound 15a) is a HDAC1/2 inhibitor (IC₅₀: 100 and 92 nM for HDAC1/2 respectively). GK444 inhibits Caco-2 cells with IC₅₀ of 4.1 μM. GK444 also reduces TGF-β1 induced COL1A1 mRNA levels in primary normal human lung fibroblasts. GK444 inhibits Bleomycin (HY-108345)-induced lung fibrosis in mice.

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CAS. Nr.: 3032392-39-2
Formel: C₃₃H₃₂N₄O₄
Molecular Weight:548.63

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

GK444 Chemical Structure

CAS. Nr.: 3032392-39-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

100 and 92 nM for HDAC1/2^[1].

Alle HDAC Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	6.8 μM Compound: 15a; GK444	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 37795958]
Caco-2	IC₅₀	1.9 μM Compound: 15a; GK444	Antiproliferative activity against human Caco-2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human Caco-2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 37795958]
SF-268	IC₅₀	4.8 μM Compound: 15a; GK444	Antiproliferative activity against human SF-268 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human SF-268 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 37795958]

Chemical Information

CAS. Nr. 3032392-39-2
Molecular Weight 548.63
Formel C₃₃H₃₂N₄O₄
SMILES

O=C([C@@H]1CCC(N1CC2=CC=CC=C2)=O)NCC3=CC=C(OCC4=CC=C(C(NC5=CC=CC=C5N)=O)C=C4)C=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Gerokonstantis DT, et al. N-(2-Aminophenyl)-benzamide Inhibitors of Class I HDAC Enzymes with Antiproliferative and Antifibrotic Activity. J Med Chem. 2023 Oct 26;66(20):14357-14376. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Reinheit & Dokumentation
Verweise

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GK444

Alle HDAC Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

GK444 Related Classifications

HY-155328 Related Classifications