Nyasol
Nyasol ((-)-Nyasol) is an active compound that has antifungal, antibacterial, antileishmanial, hyaluronidase inhibition activities. Nyasol inhibits LTB4 binding to human neutrophils. Nyasol suppresses neuroinflammatory response through the inhibition of I-κB degradation in LPS (HY-D1056)-stimulated BV-2 microglial cells.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 96895-25-9
- Formel: C17H16O2
- Molecular Weight:252.31
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Alle Parasite Isoform-spezifische Produkte anzeigen
MoreAlle Leukotriene Receptor Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| 3T3-L1 | IC50 |
>100 μM
Compound: 4
|
Antiadipogenic activity against mouse 3T3L1 cells assessed as inhibition of differentiation after 7 days by oil-red O staining
Antiadipogenic activity against mouse 3T3L1 cells assessed as inhibition of differentiation after 7 days by oil-red O staining
|
[PMID: 19757853] |
| Col2 | IC50 |
>20 μg/mL
Compound: 7
|
Cytotoxicity against human Col2 cells
Cytotoxicity against human Col2 cells
|
[PMID: 14987058] |
| HUVEC | IC50 |
>20 μg/mL
Compound: 7
|
Cytotoxicity against HUVEC
Cytotoxicity against HUVEC
|
[PMID: 14987058] |
| KB | IC50 |
>20 μg/mL
Compound: 7
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 14987058] |
| LNCaP | IC50 |
>20 μg/mL
Compound: 7
|
Cytotoxicity against human LNCAP cells
Cytotoxicity against human LNCAP cells
|
[PMID: 14987058] |
| Lu1 | IC50 |
>20 μg/mL
Compound: 7
|
Cytotoxicity against human Lu1 cells
Cytotoxicity against human Lu1 cells
|
[PMID: 14987058] |
| Lymphocyte | IC50 |
200 μM
Compound: 2, (+)-nyasol
|
Inhibition of phytohemagglutininin A-induced human lymphocyte proliferation assessed as radiolabeled [14C]thymidine uptake
Inhibition of phytohemagglutininin A-induced human lymphocyte proliferation assessed as radiolabeled [14C]thymidine uptake
|
[PMID: 9358645] |
Chemical Information
-
CAS. Nr. 96895-25-9
-
Molecular Weight 252.31
-
Formel C17H16O2
-
SMILES
C=C[C@@H](C1=CC=C(O)C=C1)/C=C\C2=CC=C(O)C=C2
-
Synonyms
(-)-Nyasol; (Z)-Hinokiresinol; cis-Hinokiresinol
-
Structure Classification
-
Initial Source
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Lim H, et al. (-)-Nyasol (cis-hinokiresinol), a norneolignan from the rhizomes of Anemarrhena asphodeloides, is a broad spectrum inhibitor of eicosanoid and nitric oxide production. Arch Pharm Res. 2009 Nov;32(11):1509-14. [Content Brief]
[2]. Iida Y, et al. In vitro synergism between nyasol, an active compound isolated from Anemarrhena asphodeloides, and azole agents against Candida albicans. Planta Med. 2000 Jun;66(5):435-8. [Content Brief]
[3]. Lee HJ, et al. (-)-Nyasol, isolated from Anemarrhena asphodeloides suppresses neuroinflammatory response through the inhibition of I-κBα degradation in LPS-stimulated BV-2 microglial cells. J Enzyme Inhib Med Chem. 2013 Oct;28(5):954-9. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Nyasol Related Classifications
HY-138050 Related Classifications
Powered by Bioz